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Synergistic cancer immunotherapy combines MVA-CD40L induced innate and adaptive immunity with tumor targeting antibodies.
Medina-Echeverz J, Hinterberger M, Testori M, Geiger M, Giessel R, Bathke B, Kassub R, Gräbnitz F, Fiore G, Wennier ST, Chaplin P, Suter M, Hochrein H, Lauterbach H. Medina-Echeverz J, et al. Among authors: giessel r. Nat Commun. 2019 Nov 6;10(1):5041. doi: 10.1038/s41467-019-12998-6. Nat Commun. 2019. PMID: 31695037 Free PMC article.
Intratumoral virotherapy with 4-1BBL armed modified vaccinia Ankara eradicates solid tumors and promotes protective immune memory.
Hinterberger M, Giessel R, Fiore G, Graebnitz F, Bathke B, Wennier S, Chaplin P, Melero I, Suter M, Lauterbach H, Berraondo P, Hochrein H, Medina-Echeverz J. Hinterberger M, et al. Among authors: giessel r. J Immunother Cancer. 2021 Feb;9(2):e001586. doi: 10.1136/jitc-2020-001586. J Immunother Cancer. 2021. PMID: 33579736 Free PMC article.