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Hyperphosphorylation tunes TDP-43 solubility.
Ginell GM, Holehouse AS. Ginell GM, et al. EMBO J. 2022 Apr 19;41(8):e111062. doi: 10.15252/embj.2022111062. Epub 2022 Mar 21. EMBO J. 2022. PMID: 35307855 Free PMC article.
Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease.
Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Haver DV, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. Boeynaems S, et al. Among authors: ginell gm. bioRxiv [Preprint]. 2023 Mar 9:2023.03.09.531820. doi: 10.1101/2023.03.09.531820. bioRxiv. 2023. PMID: 36945394 Free PMC article. Preprint.
Labile assembly of a tardigrade protein induces biostasis.
Sanchez-Martinez S, Nguyen K, Biswas S, Nicholson V, Romanyuk AV, Ramirez J, Kc S, Akter A, Childs C, Meese EK, Usher ET, Ginell GM, Yu F, Gollub E, Malferrari M, Francia F, Venturoli G, Martin EW, Caporaletti F, Giubertoni G, Woutersen S, Sukenik S, Woolfson DN, Holehouse AS, Boothby TC. Sanchez-Martinez S, et al. Among authors: ginell gm. Protein Sci. 2024 Apr;33(4):e4941. doi: 10.1002/pro.4941. Protein Sci. 2024. PMID: 38501490 Free PMC article.
14 results