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A Bispecific DLL3/CD3 IgG-Like T-Cell Engaging Antibody Induces Antitumor Responses in Small Cell Lung Cancer.

Hipp S, Voynov V, Drobits-Handl B, Giragossian C, Trapani F, Nixon AE, Scheer JM, Adam PJ. Hipp S, et al. Among authors: giragossian c. Clin Cancer Res. 2020 Oct 1;26(19):5258-5268. doi: 10.1158/1078-0432.CCR-20-0926. Epub 2020 Jun 18. Clin Cancer Res. 2020. PMID: 32554516

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Selective Tumor Cell Apoptosis and Tumor Regression in CDH17-Positive Colorectal Cancer Models using BI 905711, a Novel Liver-Sparing TRAILR2 Agonist.

García-Martínez JM, Wang S, Weishaeupl C, Wernitznig A, Chetta P, Pinto C, Ho J, Dutcher D, Gorman PN, Kroe-Barrett R, Rinnenthal J, Giragossian C, Impagnatiello MA, Tirapu I, Hilberg F, Kraut N, Pearson M, Kuenkele KP. García-Martínez JM, et al. Among authors: giragossian c. Mol Cancer Ther. 2021 Jan;20(1):96-108. doi: 10.1158/1535-7163.MCT-20-0253. Epub 2020 Oct 9. Mol Cancer Ther. 2021. PMID: 33037135

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Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings.

Germovsek E, Cheng M, Giragossian C. Germovsek E, et al. Among authors: giragossian c. MAbs. 2021 Jan-Dec;13(1):1964935. doi: 10.1080/19420862.2021.1964935. MAbs. 2021. PMID: 34530672 Free PMC article. Review.

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Quantitative Systems Pharmacology Modeling of PBMC-Humanized Mouse to Facilitate Preclinical Immuno-oncology Drug Development.

Ma H, Pilvankar M, Wang J, Giragossian C, Popel AS. Ma H, et al. Among authors: giragossian c. ACS Pharmacol Transl Sci. 2020 Dec 3;4(1):213-225. doi: 10.1021/acsptsci.0c00178. eCollection 2021 Feb 12. ACS Pharmacol Transl Sci. 2020. PMID: 33615174 Free PMC article.

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Analyze impact of tumor-associated kinetics on antibody delivery in solid tumors with a physiologically based pharmacokinetics/pharmacodynamics model.

Wang J, Giragossian C, Hansel S. Wang J, et al. Among authors: giragossian c. Eur J Pharm Biopharm. 2021 Nov;168:110-121. doi: 10.1016/j.ejpb.2021.08.019. Epub 2021 Sep 1. Eur J Pharm Biopharm. 2021. PMID: 34478854 Free article.

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Neonatal Fc receptor and its role in the absorption, distribution, metabolism and excretion of immunoglobulin G-based biotherapeutics.

Giragossian C, Clark T, Piché-Nicholas N, Bowman CJ. Giragossian C, et al. Curr Drug Metab. 2013 Sep;14(7):764-90. doi: 10.2174/13892002113149990099. Curr Drug Metab. 2013. PMID: 23952252 Review.

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A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor.

Ma H, Wang H, Sove RJ, Jafarnejad M, Tsai CH, Wang J, Giragossian C, Popel AS. Ma H, et al. Among authors: giragossian c. AAPS J. 2020 Jun 12;22(4):85. doi: 10.1208/s12248-020-00450-3. AAPS J. 2020. PMID: 32533270 Free PMC article.

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Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.

Mierke DF, Giragossian C. Mierke DF, et al. Among authors: giragossian c. Med Res Rev. 2001 Sep;21(5):450-71. doi: 10.1002/med.1018. Med Res Rev. 2001. PMID: 11579442 Review.

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Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model.

Ma H, Wang H, Sové RJ, Wang J, Giragossian C, Popel AS. Ma H, et al. Among authors: giragossian c. J Immunother Cancer. 2020 Aug;8(2):e001141. doi: 10.1136/jitc-2020-001141. J Immunother Cancer. 2020. PMID: 32859743 Free PMC article.

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Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.

Weng Y, Ishino T, Sievers A, Talukdar S, Chabot JR, Tam A, Duan W, Kerns K, Sousa E, He T, Logan A, Lee D, Li D, Zhou Y, Bernardo B, Joyce A, Kavosi M, O'Hara DM, Clark T, Guo J, Giragossian C, Stahl M, Calle RA, Kriz R, Somers W, Lin L. Weng Y, et al. Among authors: giragossian c. Sci Rep. 2018 Mar 9;8(1):4241. doi: 10.1038/s41598-018-22456-w. Sci Rep. 2018. PMID: 29523796 Free PMC article.

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