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Table representation of search results timeline featuring number of search results per year.

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1989 1
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1,350 results

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Page 1
GLI3-Related Pallister-Hall Syndrome.
Biesecker LG. Biesecker LG. 2000 May 25 [updated 2024 Feb 22]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2000 May 25 [updated 2024 Feb 22]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301638 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging from polydactyly, asymptomatic bifid epiglottis, and hypothalamic hamartoma at the mild end to laryngotracheal cleft with neonatal lethality …
CLINICAL CHARACTERISTICS: GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging …
GLI3: a mediator of genetic diseases, development and cancer.
Matissek SJ, Elsawa SF. Matissek SJ, et al. Cell Commun Signal. 2020 Apr 3;18(1):54. doi: 10.1186/s12964-020-00540-x. Cell Commun Signal. 2020. PMID: 32245491 Free PMC article. Review.
The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH activation, GLI3-FL regulates HH genes by targeting …
The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/ …
GLI3-Related Greig Cephalopolysyndactyly Syndrome.
Biesecker LG, Johnston JJ. Biesecker LG, et al. 2001 Jul 9 [updated 2025 Aug 28]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2001 Jul 9 [updated 2025 Aug 28]. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 20301619 Free Books & Documents. Review.
Developmental delay, intellectual disability, or seizures appear to be uncommon manifestations (~<10%) of GLI3-GCPS and may be more common in individuals with large (>300 kb) deletions that encompass GLI3. Approximately 20% of individuals with GLI3-GCPS …
Developmental delay, intellectual disability, or seizures appear to be uncommon manifestations (~<10%) of GLI3-GCPS and may be mor …
GLI3 regulates muscle stem cell entry into G(Alert) and self-renewal.
Brun CE, Sincennes MC, Lin AYT, Hall D, Jarassier W, Feige P, Le Grand F, Rudnicki MA. Brun CE, et al. Nat Commun. 2022 Jul 8;13(1):3961. doi: 10.1038/s41467-022-31695-5. Nat Commun. 2022. PMID: 35803939 Free PMC article.
GLI3 is required to maintain satellite cells in a G(0) dormant state. Strikingly, satellite cells lacking GLI3 enter the G(Alert) state in the absence of injury. Furthermore, GLI3 depletion stimulates expansion of the stem cell pool. As a result, satellite ce …
GLI3 is required to maintain satellite cells in a G(0) dormant state. Strikingly, satellite cells lacking GLI3 enter the G(Ale …
GLI3-related polydactyly: a review.
Al-Qattan MM, Shamseldin HE, Salih MA, Alkuraya FS. Al-Qattan MM, et al. Clin Genet. 2017 Nov;92(5):457-466. doi: 10.1111/cge.12952. Epub 2017 Feb 22. Clin Genet. 2017. PMID: 28224613 Review.
GLI3 mutations are known to be associated with nine syndromes/conditions in which polydactyly is a feature. In this review, the embryology, pathogenesis, and animal models of GLI3-related polydactyly are discussed first. This is followed by a detailed review of the …
GLI3 mutations are known to be associated with nine syndromes/conditions in which polydactyly is a feature. In this review, the embry …
GLI3 in Archaic Humans: Possible Contributions to Human Skeletal and Brain Evolution.
Nomura T, Agata A, Trinh NTM. Nomura T, et al. Dev Growth Differ. 2025 Aug;67(6):306-313. doi: 10.1111/dgd.70015. Epub 2025 Jun 23. Dev Growth Differ. 2025. PMID: 40551602 Review.
In this review, we focus on the role of GLI3, a key molecule that mediates Hedgehog signaling during vertebrate organogenesis. We discuss possible contributions of GLI3-mediated hedgehog signaling to human anatomical diversifications, including neocortical structure …
In this review, we focus on the role of GLI3, a key molecule that mediates Hedgehog signaling during vertebrate organogenesis. We dis …
Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase.
Yoshida S, Kawamura A, Aoki K, Wiriyasermkul P, Sugimoto S, Tomiyoshi J, Tajima A, Ishida Y, Katoh Y, Tsukada T, Tsuneoka Y, Yamada K, Nagamori S, Nakayama K, Yoshida K. Yoshida S, et al. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2320070121. doi: 10.1073/pnas.2320070121. Epub 2024 Jul 5. Proc Natl Acad Sci U S A. 2024. PMID: 38968120 Free PMC article.
Multiple negative regulators are known to govern Hh signaling; however, how activated Smoothened (SMO) participates in the activation of downstream GLI2 and GLI3 remains unclear. Herein, we identified the ciliary kinase DYRK2 as a positive regulator of the GLI2 and GLI3 …
Multiple negative regulators are known to govern Hh signaling; however, how activated Smoothened (SMO) participates in the activation of dow …
Pallister-Hall syndrome, GLI3, and kidney malformation.
McClelland K, Li W, Rosenblum ND. McClelland K, et al. Am J Med Genet C Semin Med Genet. 2022 Sep;190(3):264-278. doi: 10.1002/ajmg.c.31999. Epub 2022 Sep 27. Am J Med Genet C Semin Med Genet. 2022. PMID: 36165461
The observed clinical phenotypes are consistent with the essential role of GLI3, a transcriptional effector in the hedgehog (Hh) signaling pathway, in organogenesis. However, the mechanisms by which truncation of GLI3 in PHS results in such a variety of clinical phe …
The observed clinical phenotypes are consistent with the essential role of GLI3, a transcriptional effector in the hedgehog (Hh) sign …
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.
Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO. Sun J, et al. Cell Rep. 2022 Feb 1;38(5):110312. doi: 10.1016/j.celrep.2022.110312. Cell Rep. 2022. PMID: 35108539 Free PMC article.
Further, Zic5 interacts with the critical Hh signaling molecule, Gli3, through the zinc finger domains of both proteins. This Zic5-Gli3 interaction disrupts Gli3/Gli3 homodimerization, resulting in Gli3 protein stabilization via a reduction in …
Further, Zic5 interacts with the critical Hh signaling molecule, Gli3, through the zinc finger domains of both proteins. This Zic5- …
Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.
Taroc EZM, Naik AS, Lin JM, Peterson NB, Keefe DL Jr, Genis E, Fuchs G, Balasubramanian R, Forni PE. Taroc EZM, et al. J Neurosci. 2020 Jan 8;40(2):311-326. doi: 10.1523/JNEUROSCI.1977-19.2019. Epub 2019 Nov 25. J Neurosci. 2020. PMID: 31767679 Free PMC article.
Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in GnRH-1 neuronal development is unclear. By analyzing Gli3 extra-toe mutants (Gli3(Xt/Xt)), we found that Gli3 loss-of-f …
Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in …
1,350 results