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Page 1
GLI3-Related Pallister-Hall Syndrome.
Biesecker LG. Biesecker LG. 2000 May 25 [updated 2024 Feb 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2000 May 25 [updated 2024 Feb 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301638 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging from polydactyly, asymptomatic bifid epiglottis, and hypothalamic hamartoma at the mild end to laryngotracheal cleft with neonatal lethality …
CLINICAL CHARACTERISTICS: GLI3-related Pallister-Hall syndrome (GLI3-PHS) is characterized by a spectrum of anomalies ranging …
GLI3: a mediator of genetic diseases, development and cancer.
Matissek SJ, Elsawa SF. Matissek SJ, et al. Cell Commun Signal. 2020 Apr 3;18(1):54. doi: 10.1186/s12964-020-00540-x. Cell Commun Signal. 2020. PMID: 32245491 Free PMC article. Review.
The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH activation, GLI3-FL regulates HH genes by targeting …
The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/ …
GLI3-related polydactyly: a review.
Al-Qattan MM, Shamseldin HE, Salih MA, Alkuraya FS. Al-Qattan MM, et al. Clin Genet. 2017 Nov;92(5):457-466. doi: 10.1111/cge.12952. Epub 2017 Feb 22. Clin Genet. 2017. PMID: 28224613 Review.
GLI3 mutations are known to be associated with nine syndromes/conditions in which polydactyly is a feature. In this review, the embryology, pathogenesis, and animal models of GLI3-related polydactyly are discussed first. This is followed by a detailed review of the …
GLI3 mutations are known to be associated with nine syndromes/conditions in which polydactyly is a feature. In this review, the embry …
GLI3 regulates muscle stem cell entry into G(Alert) and self-renewal.
Brun CE, Sincennes MC, Lin AYT, Hall D, Jarassier W, Feige P, Le Grand F, Rudnicki MA. Brun CE, et al. Nat Commun. 2022 Jul 8;13(1):3961. doi: 10.1038/s41467-022-31695-5. Nat Commun. 2022. PMID: 35803939 Free PMC article.
GLI3 is required to maintain satellite cells in a G(0) dormant state. Strikingly, satellite cells lacking GLI3 enter the G(Alert) state in the absence of injury. Furthermore, GLI3 depletion stimulates expansion of the stem cell pool. As a result, satellite ce …
GLI3 is required to maintain satellite cells in a G(0) dormant state. Strikingly, satellite cells lacking GLI3 enter the G(Ale …
Pallister-Hall syndrome, GLI3, and kidney malformation.
McClelland K, Li W, Rosenblum ND. McClelland K, et al. Am J Med Genet C Semin Med Genet. 2022 Sep;190(3):264-278. doi: 10.1002/ajmg.c.31999. Epub 2022 Sep 27. Am J Med Genet C Semin Med Genet. 2022. PMID: 36165461
The observed clinical phenotypes are consistent with the essential role of GLI3, a transcriptional effector in the hedgehog (Hh) signaling pathway, in organogenesis. However, the mechanisms by which truncation of GLI3 in PHS results in such a variety of clinical phe …
The observed clinical phenotypes are consistent with the essential role of GLI3, a transcriptional effector in the hedgehog (Hh) sign …
Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development.
Sun J, Yoon J, Lee M, Lee HK, Hwang YS, Daar IO. Sun J, et al. Cell Rep. 2022 Feb 1;38(5):110312. doi: 10.1016/j.celrep.2022.110312. Cell Rep. 2022. PMID: 35108539 Free PMC article.
Further, Zic5 interacts with the critical Hh signaling molecule, Gli3, through the zinc finger domains of both proteins. This Zic5-Gli3 interaction disrupts Gli3/Gli3 homodimerization, resulting in Gli3 protein stabilization via a reduction in …
Further, Zic5 interacts with the critical Hh signaling molecule, Gli3, through the zinc finger domains of both proteins. This Zic5- …
GLI3 Is Associated With Neuronal Differentiation in SHH-Activated and WNT-Activated Medulloblastoma.
Natsumeda M, Miyahara H, Yoshimura J, Nakata S, Nozawa T, Ito J, Kanemaru Y, Watanabe J, Tsukamoto Y, Okada M, Oishi M, Hirato J, Wataya T, Ahsan S, Tateishi K, Yamamoto T, Rodriguez FJ, Takahashi H, Hovestadt V, Suva ML, Taylor MD, Eberhart CG, Fujii Y, Kakita A. Natsumeda M, et al. J Neuropathol Exp Neurol. 2021 Jan 20;80(2):129-136. doi: 10.1093/jnen/nlaa141. J Neuropathol Exp Neurol. 2021. PMID: 33249504
Analysis of bulk mRNA expression data and single cell RNA sequencing studies confirmed that GLI1 and GLI3 are highly expressed in SHH-activated medulloblastoma, whereas GLI3 but not GLI1 is highly expressed in WNT-activated medulloblastoma. ...In contrast, GLI3 …
Analysis of bulk mRNA expression data and single cell RNA sequencing studies confirmed that GLI1 and GLI3 are highly expressed in SHH …
GLI3 Promotes Invasion and Predicts Poor Prognosis in Colorectal Cancer.
Shen M, Zhang Z, Wang P. Shen M, et al. Biomed Res Int. 2021 Jan 9;2021:8889986. doi: 10.1155/2021/8889986. eCollection 2021. Biomed Res Int. 2021. PMID: 33506047 Free PMC article.
METHODS: A series of bioinformatic approaches were combined and identify GLI3 as a potential key regulator in EMT. In vitro experiments were performed to knockdown GLI3 expression in two CRC cell lines and to reveal the oncogenic role of GLI3 in CRC. qRT-PCR …
METHODS: A series of bioinformatic approaches were combined and identify GLI3 as a potential key regulator in EMT. In vitro experimen …
Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration.
Taroc EZM, Naik AS, Lin JM, Peterson NB, Keefe DL Jr, Genis E, Fuchs G, Balasubramanian R, Forni PE. Taroc EZM, et al. J Neurosci. 2020 Jan 8;40(2):311-326. doi: 10.1523/JNEUROSCI.1977-19.2019. Epub 2019 Nov 25. J Neurosci. 2020. PMID: 31767679 Free PMC article.
Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in GnRH-1 neuronal development is unclear. By analyzing Gli3 extra-toe mutants (Gli3(Xt/Xt)), we found that Gli3 loss-of-f …
Loss-of-function of the transcription factor Gli3 is known to disrupt olfactory development, however, if Gli3 plays a role in …
GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells.
Lin M, Zhu H, Shen Q, Sun LZ, Zhu X. Lin M, et al. Cell Signal. 2022 Apr;92:110278. doi: 10.1016/j.cellsig.2022.110278. Epub 2022 Feb 5. Cell Signal. 2022. PMID: 35134468 Free article.
Furthermore, knockdown of AR expression was effective in inhibiting the growth and migration of AR-positive ovarian and breast cancer cells in the presence of GLI3, but not in GLI3 knockdown cells. Similarly, ectopic expression of AR promoted the growth and migratio …
Furthermore, knockdown of AR expression was effective in inhibiting the growth and migration of AR-positive ovarian and breast cancer cells …
1,295 results