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317 results

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Page 1
PHF8-GLUL axis in lipid deposition and tumor growth of clear cell renal cell carcinoma.
Peng S, Wang Z, Tang P, Wang S, Huang Y, Xie Q, Wang Y, Tan X, Tang T, Yan X, Xu J, Lan W, Wang L, Zhang D, Wang B, Pan T, Qin J, Jiang J, Liu Q. Peng S, et al. Sci Adv. 2023 Aug 2;9(31):eadf3566. doi: 10.1126/sciadv.adf3566. Epub 2023 Aug 2. Sci Adv. 2023. PMID: 37531433 Free PMC article.
Subsequently, TEAD1 up-regulates GLUL transcriptionally. Pharmacological inhibition of GLUL by l-methionine sulfoximine not only repressed ccRCC lipid deposition and tumor growth but also enhanced the anticancer effects of everolimus. Thus, the PHF8-GLUL axis …
Subsequently, TEAD1 up-regulates GLUL transcriptionally. Pharmacological inhibition of GLUL by l-methionine sulfoximine not on …
GLUL mediates FOXO3 O-GlcNAcylation to regulate the osteogenic differentiation of BMSCs and senile osteoporosis.
Zhang L, Qi B, Li Y, Liang X, Zhang Z, Yang T, Jia S, Gao X, Chen S, Jiao G, Li Y, Zhou H, Chen Y, Li Y, Zhang B, Li G, Meng C. Zhang L, et al. Cell Death Differ. 2025 Dec;32(12):2399-2411. doi: 10.1038/s41418-025-01543-2. Epub 2025 Jul 11. Cell Death Differ. 2025. PMID: 40646162 Free PMC article.
Here, we found that GLUL expression was downregulated in the BMSCs of SOP patients. Mice with BMSC-specific Glul-knockout (KO) exhibited dysplasia of the skull and phalanges and osteoporosis due to disordered osteogenic differentiation. ...Moreover, blocking the O-G …
Here, we found that GLUL expression was downregulated in the BMSCs of SOP patients. Mice with BMSC-specific Glul-knockout (KO) …
GLUL stabilizes N-Cadherin by antagonizing beta-Catenin to inhibit the progresses of gastric cancer.
Jiang Q, Li Y, Cai S, Shi X, Yang Y, Xing Z, He Z, Wang S, Su Y, Chen M, Chen Z, Shi Z. Jiang Q, et al. Acta Pharm Sin B. 2024 Feb;14(2):698-711. doi: 10.1016/j.apsb.2023.11.008. Epub 2023 Nov 9. Acta Pharm Sin B. 2024. PMID: 38322340 Free PMC article.
Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. In the present study, we have found that the expression level of GLUL was significantly lower in gastric cancer tissues compared wit …
Although GLUL plays a critical role in multiple cancers, the expression and function of GLUL in gastric cancer remain unclear. …
SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL.
Zhang M, Chen C, Zhang H, Long T, Wang T, Ding N, Long R, Wu H, Ma Z, Cheng Z, Tao J, Kuang D, Li L, Xu C. Zhang M, et al. Gut. 2025 Oct 23:gutjnl-2025-335729. doi: 10.1136/gutjnl-2025-335729. Online ahead of print. Gut. 2025. PMID: 41136182
SIRT6 promoted glutamine synthesis by enhancing GLUL transcription and stabilising GLUL protein degradation. SIRT6 silencing decreased glutamine levels, subsequently reducing the levels of nucleotides and amino acids in ICC cells. Thus, SIRT6 or GLUL inhibito …
SIRT6 promoted glutamine synthesis by enhancing GLUL transcription and stabilising GLUL protein degradation. SIRT6 silencing d …
A glutamine metabolic switch supports erythropoiesis.
Lyu J, Gu Z, Zhang Y, Vu HS, Lechauve C, Cai F, Cao H, Keith J, Brancaleoni V, Granata F, Motta I, Cappellini MD, Huang LJ, DeBerardinis RJ, Weiss MJ, Ni M, Xu J. Lyu J, et al. Science. 2024 Nov 15;386(6723):eadh9215. doi: 10.1126/science.adh9215. Epub 2024 Nov 15. Science. 2024. PMID: 39541460 Free PMC article.
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M. Polletta L, et al. Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778. Autophagy. 2015. PMID: 25700560 Free PMC article.
GLUL Confers Perivascular Cancer-Associated Fibroblasts With Pro-Angiogenic Capacity to Promote Glioma Progression.
Zhang Q, Liu Y, Zhang Z, Wang Y, Liu F. Zhang Q, et al. Adv Sci (Weinh). 2026 Feb;13(8):e13184. doi: 10.1002/advs.202513184. Epub 2025 Dec 8. Adv Sci (Weinh). 2026. PMID: 41355614 Free PMC article.
Additionally, CAF-specific GLUL knockdown attenuates tumor growth and extends median survival in a humanized orthotopic glioma model. ...This study highlights that targeting GLUL in CAFs is a novel stroma-focused therapeutic paradigm for GBM by disrupting pro-angiog …
Additionally, CAF-specific GLUL knockdown attenuates tumor growth and extends median survival in a humanized orthotopic glioma model. …
GLUL Promotes Cell Proliferation in Breast Cancer.
Wang Y, Fan S, Lu J, Zhang Z, Wu D, Wu Z, Zheng Y. Wang Y, et al. J Cell Biochem. 2017 Aug;118(8):2018-2025. doi: 10.1002/jcb.25775. Epub 2017 Apr 21. J Cell Biochem. 2017. PMID: 27791265
In addition, GLUL was heterogeneously expressed in various breast cancer cells. The mRNA and protein expression levels of GLUL in SK-BR-3 cells were obviously higher than that in the other types of breast cancer cells. Results showed GLUL knockdown in SK-BR-3 …
In addition, GLUL was heterogeneously expressed in various breast cancer cells. The mRNA and protein expression levels of GLUL …
m(6)A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression.
Xie YX, Wang L, Zhou ZH, Liu WJ, Wang W, Yang JH, He ML, Qiu JG, Jiang BH. Xie YX, et al. J Hazard Mater. 2024 Dec 5;480:136093. doi: 10.1016/j.jhazmat.2024.136093. Epub 2024 Oct 9. J Hazard Mater. 2024. PMID: 39405702 Free article.
We demonstrated that METTL16 promoted GLUL expression in a m6A-dependent manner. Furthermore, METTL16 methylated the specific stem-loop structure of GLUL transcript, thereby increased the recognition and splicing of pre-GLUL RNA modified site by m6A reader YT …
We demonstrated that METTL16 promoted GLUL expression in a m6A-dependent manner. Furthermore, METTL16 methylated the specific stem-lo …
317 results