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92 results

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Morphology of GNAT3-immunoreactive chemosensory cells in the rat larynx.
Masuda H, Nakamuta N, Yamamoto Y. Masuda H, et al. J Anat. 2019 Feb;234(2):149-164. doi: 10.1111/joa.12914. Epub 2018 Nov 23. J Anat. 2019. PMID: 30467855 Free PMC article.
GNAT3-immunoreactive solitary chemosensory cells were slender with elongated processes or had a flask-like/columnar shape. The number of GNAT3-immunoreactive cells in chemosensory clusters was 6.1 0.4, ranging between 2 and 14 cells. ...
GNAT3-immunoreactive solitary chemosensory cells were slender with elongated processes or had a flask-like/columnar shape. The number …
The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice.
Hoffman MT, Kemp SB, Salas-Escabillas DJ, Zhang Y, Steele NG, The S, Long D, Benitz S, Yan W, Margolskee RF, Bednar F, Pasca di Magliano M, Wen HJ, Crawford HC. Hoffman MT, et al. Cell Mol Gastroenterol Hepatol. 2021;11(2):349-369. doi: 10.1016/j.jcmgh.2020.08.011. Epub 2020 Aug 31. Cell Mol Gastroenterol Hepatol. 2021. PMID: 32882403 Free PMC article.
Here, we evaluated the immunomodulatory role of chemosensory signaling in metaplastic tuft cells (MTCs) by analyzing the role of GNAT3, a gustatory pathway G-protein expressed by MTCs, during PDA progression. METHODS: Gnat3-null (Gnat3(-/-)) mice were crossbr …
Here, we evaluated the immunomodulatory role of chemosensory signaling in metaplastic tuft cells (MTCs) by analyzing the role of GNAT3 …
Morphology of GNAT3-immunoreactive chemosensory cells in the nasal cavity and pharynx of the rat.
Yamamoto Y, Yokoyama T, Nakamuta N. Yamamoto Y, et al. J Anat. 2021 Aug;239(2):290-306. doi: 10.1111/joa.13424. Epub 2021 Mar 6. J Anat. 2021. PMID: 33677835 Free PMC article.
GNAT3-immunoreactive chemosensory cells were in close contact with a few SP- or CGRP-immunoreactive nerve endings. In the pharynx, GNAT3-immunoreactive chemosensory cells were also attached to P2X3-immunoreactive nerve endings. ...
GNAT3-immunoreactive chemosensory cells were in close contact with a few SP- or CGRP-immunoreactive nerve endings. In the pharynx, …
LPAR5, GNAT3 and partial amino acid transporters messenger RNA expression patterns in digestive tracts, metabolic organs and muscle tissues of growing goats.
Zhu X, Jiao J, Zhou C, Tang S, Wang M, Kang J, Han X, Tan Z. Zhu X, et al. Animal. 2019 Jul;13(7):1394-1402. doi: 10.1017/S1751731118002823. Epub 2018 Oct 31. Animal. 2019. PMID: 30378518 Free article.
This study was conducted to investigate the messenger RNA expression patterns of lysophosphatidic acid receptor 5 (LPAR5), guanine nucleotide-binding protein alpha-transducing 3 (GNAT3) and important partial AA transporters in digestive tracts, metabolic organs and muscles …
This study was conducted to investigate the messenger RNA expression patterns of lysophosphatidic acid receptor 5 (LPAR5), guanine nucleotid …
Worldwide diversity, association potential, and natural selection in the superimposed taste genes, CD36 and GNAT3.
Wooding SP, Ramirez VA. Wooding SP, et al. Chem Senses. 2022 Jan 1;47:bjab052. doi: 10.1093/chemse/bjab052. Chem Senses. 2022. PMID: 34972209 Free article.
CD36 and GNAT3 mediate taste responses, with CD36 acting as a lipid detector and GNAT3 acting as the alpha subunit of gustducin, a G protein governing sweet, savory, and bitter transduction. Strikingly, the genes encoding CD36 and GNAT3 are genomically superi …
CD36 and GNAT3 mediate taste responses, with CD36 acting as a lipid detector and GNAT3 acting as the alpha subunit of gustduci …
Pig Taste Cell-derived Organoids Synthesize Insulin.
Premathilake HU, Mazucanti CH, Yao Q, O'Connell JF, Vegesna N, Tsitsipatis D, Weller C, Lam KG, Candia J, Fan J, De S, Sen P, Egan JM, Doyle ME. Premathilake HU, et al. Endocrinology. 2025 Jul 8;166(9):bqaf126. doi: 10.1210/endocr/bqaf126. Endocrinology. 2025. PMID: 40755411 Free PMC article.
Pig taste organoids were maintained long term (18 passages) and continued to express taste stem cell markers (LGR4, LGR6, and SOX2) and taste receptor cell (TRC) markers (cytokeratin 20, ENTPD2, GNAT3, and OTOP1). We show insulin is necessary for optimum proliferation and …
Pig taste organoids were maintained long term (18 passages) and continued to express taste stem cell markers (LGR4, LGR6, and SOX2) and tast …
Gustation genetics: sweet gustducin!
Reed DR, Margolskee RF. Reed DR, et al. Chem Senses. 2010 Sep;35(7):549-50. doi: 10.1093/chemse/bjq059. Epub 2010 Jul 21. Chem Senses. 2010. PMID: 20660058 Free PMC article.
Two recent studies, the second of which is reported herein, provide evidence that genetic variation in the sweet receptor subunit, TAS1R3, and the second messenger, gustducin (GNAT3), affect the ability of people to correctly sort ascending concentrations of sucrose. These …
Two recent studies, the second of which is reported herein, provide evidence that genetic variation in the sweet receptor subunit, TAS1R3, a …
Salicin alleviates periodontitis via Tas2r143/gustducin signaling in fibroblasts.
Zhang Z, Zhou Z, Liu J, Zheng L, Peng X, Zhao L, Zheng X, Xu X. Zhang Z, et al. Front Immunol. 2024 Mar 28;15:1374900. doi: 10.3389/fimmu.2024.1374900. eCollection 2024. Front Immunol. 2024. PMID: 38605968 Free PMC article.
The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a ligature-induced periodontitis mouse model using Ga-gustducin-null (Gnat3(-/-)) mice. RESULTS: The expression of Tas2r143, Gnat3, …
The anti-inflammatory effects of salicin against LPS-induced MGFs were investigated in cell cultures, and were further validated with a liga …
Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans.
Farook VS, Puppala S, Schneider J, Fowler SP, Chittoor G, Dyer TD, Allayee H, Cole SA, Arya R, Black MH, Curran JE, Almasy L, Buchanan TA, Jenkinson CP, Lehman DM, Watanabe RM, Blangero J, Duggirala R. Farook VS, et al. Obesity (Silver Spring). 2012 Oct;20(10):2083-92. doi: 10.1038/oby.2012.74. Epub 2012 Mar 29. Obesity (Silver Spring). 2012. PMID: 22456541 Free PMC article.
Furthermore, we examined 29 single-nucleotide polymorphisms (SNPs) from the fatty acid translocase (FAT or CD36, 18 SNPs) gene and guanine nucleotide binding protein, alpha transducing 3 (GNAT3, 11 SNPs) gene, located within the 1-LOD support interval region for their asso …
Furthermore, we examined 29 single-nucleotide polymorphisms (SNPs) from the fatty acid translocase (FAT or CD36, 18 SNPs) gene and guanine n …
Genetic mutation of Tas2r104/Tas2r105/Tas2r114 cluster leads to a loss of taste perception to denatonium benzoate and cucurbitacin B.
Niu B, Liu L, Gao Q, Zhu MM, Chen L, Peng XH, Qin B, Zhou X, Li F. Niu B, et al. Animal Model Exp Med. 2024 Jun;7(3):324-336. doi: 10.1002/ame2.12357. Epub 2023 Dec 28. Animal Model Exp Med. 2024. PMID: 38155461 Free PMC article.
METHODS: To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and extraoral tissues, multiple Tas2rs mutant mice and Gnat3 were produced using CRISPR/Cas9 gene-editing technique. A mixture containing …
METHODS: To investigate the physiological functions of the bitter taste receptor cluster Tas2r106/Tas2r104/Tas2r105/Tas2r114 in lingual and …
92 results