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Sarcoidosis is a Th1/Th17 multisystem disorder.
Facco M, Cabrelle A, Teramo A, Olivieri V, Gnoato M, Teolato S, Ave E, Gattazzo C, Fadini GP, Calabrese F, Semenzato G, Agostini C. Facco M, et al. Among authors: gnoato m. Thorax. 2011 Feb;66(2):144-50. doi: 10.1136/thx.2010.140319. Epub 2010 Dec 7. Thorax. 2011. PMID: 21139119
3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
Gurrieri C, Piazza F, Gnoato M, Montini B, Biasutto L, Gattazzo C, Brunetta E, Cabrelle A, Cinetto F, Niero R, Facco M, Garbisa S, Calabrese F, Semenzato G, Agostini C. Gurrieri C, et al. Among authors: gnoato m. J Pharmacol Exp Ther. 2010 Mar;332(3):785-94. doi: 10.1124/jpet.109.153049. Epub 2009 Dec 3. J Pharmacol Exp Ther. 2010. PMID: 19959748