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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson's disease pathogenesis.
Carballo-Carbajal I, Laguna A, Romero-Giménez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodríguez-Galván B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M. Carballo-Carbajal I, et al. Among authors: gonzalez sepulveda m. Nat Commun. 2019 Mar 7;10(1):973. doi: 10.1038/s41467-019-08858-y. Nat Commun. 2019. PMID: 30846695 Free PMC article.
Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase.
González-Sepúlveda M, Omar MY, Hamdon S, Ma G, Rosell-Vilar S, Raivio N, Abass D, Martínez-Rivas A, Vila M, Giraldo J, Carrascal M, Abián J, Gil C, Sabriá J, Ortiz J, Moreno-Delgado D. González-Sepúlveda M, et al. Neuropharmacology. 2022 Jul 1;212:109058. doi: 10.1016/j.neuropharm.2022.109058. Epub 2022 Apr 13. Neuropharmacology. 2022. PMID: 35429504 Free article.
Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue.
Gonzalez-Sepulveda M, Laguna A, Carballo-Carbajal I, Galiano-Landeira J, Romero-Gimenez J, Cuadros T, Parent A, Peñuelas N, Compte J, Nicolau A, Guillard-Sirieix C, Xicoy H, Kobayashi J, Vila M. Gonzalez-Sepulveda M, et al. ACS Chem Neurosci. 2020 Sep 2;11(17):2679-2687. doi: 10.1021/acschemneuro.0c00336. Epub 2020 Aug 24. ACS Chem Neurosci. 2020. PMID: 32786306
Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.
Moreno E, Hoffmann H, Gonzalez-Sepúlveda M, Navarro G, Casadó V, Cortés A, Mallol J, Vignes M, McCormick PJ, Canela EI, Lluís C, Moratalla R, Ferré S, Ortiz J, Franco R. Moreno E, et al. Among authors: gonzalez sepulveda m. J Biol Chem. 2011 Feb 18;286(7):5846-54. doi: 10.1074/jbc.M110.161489. Epub 2010 Dec 20. J Biol Chem. 2011. PMID: 21173143 Free PMC article.
11 results