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264 results

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Oncogenic GOPC-ROS1 fusion promotes the formation of lymphatic malformations by impairing tight junction and its crizotinib resistance through repressing ferroptosis.
Tian R, Weng Z, Liang H, Zhang C, He Q, Li J, Zhang R, Yin X, Deng D, Hong L, Gu S, Zhan Z. Tian R, et al. Biochem Pharmacol. 2025 Dec;242(Pt 1):117243. doi: 10.1016/j.bcp.2025.117243. Epub 2025 Aug 15. Biochem Pharmacol. 2025. PMID: 40819798
In this study, we identified a complex LM with Golgi-associated PDZ and coiled-coil motif containing (GOPC)-proto-oncogene ROS 1 (ROS1) fusion that responds to crizotinib. The oncogenic roles of GOPC-ROS1 fusion in the formation of LMs remain unknown. ...Targeting f …
In this study, we identified a complex LM with Golgi-associated PDZ and coiled-coil motif containing (GOPC)-proto-oncogene ROS 1 (ROS …
GOPC facilitates the sorting of syndecan-1 in polarized epithelial cells.
Ford C, Burd CG. Ford C, et al. Mol Biol Cell. 2022 Sep 1;33(10):ar86. doi: 10.1091/mbc.E22-05-0165. Epub 2022 Jul 13. Mol Biol Cell. 2022. PMID: 35830596 Free PMC article.
Instead, we reveal that correct basolateral targeting of syndecan-1 requires a full-length PDZ motif in syndecan-1 and the PDZ domain golgin protein GOPC. Moreover, we reveal changes in Golgi morphology elicited by GOPC overexpression. These results suggest that the …
Instead, we reveal that correct basolateral targeting of syndecan-1 requires a full-length PDZ motif in syndecan-1 and the PDZ domain golgin …
GOPC-ROS1 mosaicism in agminated Spitz naevi: report of two cases.
Goto K, Pissaloux D, Kauer F, Huriet V, Tirode F, de la Fouchardière A. Goto K, et al. Virchows Arch. 2021 Sep;479(3):559-564. doi: 10.1007/s00428-020-02992-5. Epub 2021 Mar 17. Virchows Arch. 2021. PMID: 33733342
We report two cases of agminated Spitz naevi with a GOPC-ROS1 fusion. Both cases occurred on the lower limb of young adults. Since adolescence, pigmented or pink-colored papules have been periodically arising in a limited area of skin. ...These findings suggest the presenc …
We report two cases of agminated Spitz naevi with a GOPC-ROS1 fusion. Both cases occurred on the lower limb of young adults. Since ad …
UCHL3-mediated proteasomal degradation of GOPC drives microcystin-LR-induced acrosomal dysgenesis.
Gan Y, Xu D, Zhang Y, Ma Y, Han X, Chen Y. Gan Y, et al. Environ Pollut. 2025 Nov 1;384:126969. doi: 10.1016/j.envpol.2025.126969. Epub 2025 Aug 8. Environ Pollut. 2025. PMID: 40784473
MC-LR directly bound to catalytic domain of UCHL3, obstructing its interaction with GOPC and inhibiting its enzymatic activity. MC-LR was also found to suppresses UCHL3 transcription and destabilizes UCHL3 protein stability. Further studies showed that UCHL3 dysfunction tr …
MC-LR directly bound to catalytic domain of UCHL3, obstructing its interaction with GOPC and inhibiting its enzymatic activity. MC-LR …
ROS1-GOPC/FIG: a novel gene fusion in hepatic angiosarcoma.
Marks EI, Pamarthy S, Dizon D, Birnbaum A, Yakirevich E, Safran H, Carneiro BA. Marks EI, et al. Oncotarget. 2019 Jan 4;10(2):245-251. doi: 10.18632/oncotarget.26521. eCollection 2019 Jan 4. Oncotarget. 2019. PMID: 30719217 Free PMC article.
We describe the first reported case of a patient with HAS that harbored a fusion of ROS1 with GOPC/FIG. Similar to other rearrangements involving ROS1, the resulting fusion protein is believed to act as a major driver of carcinogenesis and may be subject to inhibition by d …
We describe the first reported case of a patient with HAS that harbored a fusion of ROS1 with GOPC/FIG. Similar to other rearrangemen …
GOPC:ROS1 and other ROS1 fusions represent a rare but recurrent drug target in a variety of glioma types.
Sievers P, Stichel D, Sill M, Schrimpf D, Sturm D, Selt F, Ecker J, Kazdal D, Miele E, Kranendonk MEG, Tops BBJ, Kohlhof-Meinecke P, Beschorner R, Kramm CM, Hasselblatt M, Reifenberger G, Capper D, Wesseling P, Stenzinger A, Milde T, Korshunov A, Witt O, Pfister SM, Wick W, von Deimling A, Jones DTW, Sahm F. Sievers P, et al. Acta Neuropathol. 2021 Dec;142(6):1065-1069. doi: 10.1007/s00401-021-02369-1. Epub 2021 Sep 18. Acta Neuropathol. 2021. PMID: 34536122 Free PMC article. No abstract available.
Zona Pellucida sperm-binding protein 3 receptor distribution during Gopc(-/-) globozoospermic spermatogenesis.
Bizkarguenaga M, Gomez-Santos L, Madrid JF, Sáez FJ, Alonso E. Bizkarguenaga M, et al. Microsc Res Tech. 2022 Apr;85(4):1454-1464. doi: 10.1002/jemt.24009. Epub 2021 Dec 6. Microsc Res Tech. 2022. PMID: 34870349
In this study, Western blot, RT-PCR, immunohistochemistry and immunogold were done for the localization of the acrosome protein Zona Pellucida sperm-binding protein 3 receptor (ZP3R), also called sp56, in wild type and Gopc(-/-) mice testis. The ZP3R protein was located in …
In this study, Western blot, RT-PCR, immunohistochemistry and immunogold were done for the localization of the acrosome protein Zona Pelluci …
GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors.
Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. Richardson TE, et al. J Neuropathol Exp Neurol. 2019 Dec 1;78(12):1089-1099. doi: 10.1093/jnen/nlz093. J Neuropathol Exp Neurol. 2019. PMID: 31626289
In this report, we identify 3 cases of unusual pediatric glioma with GOPC-ROS1 fusion. We reviewed the clinical history, radiologic and histologic features, performed methylation analysis, whole genome copy number profiling, and next generation sequencing analysis for the …
In this report, we identify 3 cases of unusual pediatric glioma with GOPC-ROS1 fusion. We reviewed the clinical history, radiologic a …
Scaffolding protein GOPC regulates tight junction structure.
Lu R, Stewart L, Wilson JM. Lu R, et al. Cell Tissue Res. 2015 May;360(2):321-32. doi: 10.1007/s00441-014-2088-1. Epub 2015 Jan 24. Cell Tissue Res. 2015. PMID: 25616555 Free PMC article.
In Madin-Darby canine kidney (MDCK) cells, we find that GOPC localizes to the trans-Golgi network (TGN) but not to the cis- or trans-Golgi cisternae. Colocalization occurs with the early endosome Rab GTPase Rab5 and a TGN/endosome marker Rab14 but not with Rab11, a marker …
In Madin-Darby canine kidney (MDCK) cells, we find that GOPC localizes to the trans-Golgi network (TGN) but not to the cis- or trans- …
264 results