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CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.

Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, Jin RA, Liang X, Cai X. Xu J, et al. Among authors: gorshkov k. Signal Transduct Target Ther. 2020 Dec 26;5(1):298. doi: 10.1038/s41392-020-00375-5. Signal Transduct Target Ther. 2020. PMID: 33361760 Free PMC article.

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N⁶-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling.

Xu J, Wan Z, Tang M, Lin Z, Jiang S, Ji L, Gorshkov K, Mao Q, Xia S, Cen D, Zheng J, Liang X, Cai X. Xu J, et al. Among authors: gorshkov k. Mol Cancer. 2020 Nov 23;19(1):163. doi: 10.1186/s12943-020-01281-8. Mol Cancer. 2020. PMID: 33222692 Free PMC article.

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Drug Discovery Strategies for SARS-CoV-2.

Shyr ZA, Gorshkov K, Chen CZ, Zheng W. Shyr ZA, et al. Among authors: gorshkov k. J Pharmacol Exp Ther. 2020 Oct;375(1):127-138. doi: 10.1124/jpet.120.000123. Epub 2020 Jul 28. J Pharmacol Exp Ther. 2020. PMID: 32723801 Free PMC article. Review.

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RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery.

Zhu W, Chen CZ, Gorshkov K, Xu M, Lo DC, Zheng W. Zhu W, et al. Among authors: gorshkov k. SLAS Discov. 2020 Dec;25(10):1141-1151. doi: 10.1177/2472555220942123. Epub 2020 Jul 13. SLAS Discov. 2020. PMID: 32660307 Free PMC article. Review.

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Neural stem cells for disease modeling and evaluation of therapeutics for Tay-Sachs disease.

Vu M, Li R, Baskfield A, Lu B, Farkhondeh A, Gorshkov K, Motabar O, Beers J, Chen G, Zou J, Espejo-Mojica AJ, Rodríguez-López A, Alméciga-Díaz CJ, Barrera LA, Jiang X, Ory DS, Marugan JJ, Zheng W. Vu M, et al. Among authors: gorshkov k. Orphanet J Rare Dis. 2018 Sep 17;13(1):152. doi: 10.1186/s13023-018-0886-3. Orphanet J Rare Dis. 2018. PMID: 30220252 Free PMC article.

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Astrocytes as targets for drug discovery.

Gorshkov K, Aguisanda F, Thorne N, Zheng W. Gorshkov K, et al. Drug Discov Today. 2018 Mar;23(3):673-680. doi: 10.1016/j.drudis.2018.01.011. Epub 2018 Jan 6. Drug Discov Today. 2018. PMID: 29317338 Free PMC article. Review.

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Advancing precision medicine with personalized drug screening.

Gorshkov K, Chen CZ, Marshall RE, Mihatov N, Choi Y, Nguyen DT, Southall N, Chen KG, Park JK, Zheng W. Gorshkov K, et al. Drug Discov Today. 2019 Jan;24(1):272-278. doi: 10.1016/j.drudis.2018.08.010. Epub 2018 Aug 17. Drug Discov Today. 2019. PMID: 30125678 Free PMC article. Review.

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Induced pluripotent stem cells for neural drug discovery.

Farkhondeh A, Li R, Gorshkov K, Chen KG, Might M, Rodems S, Lo DC, Zheng W. Farkhondeh A, et al. Among authors: gorshkov k. Drug Discov Today. 2019 Apr;24(4):992-999. doi: 10.1016/j.drudis.2019.01.007. Epub 2019 Jan 18. Drug Discov Today. 2019. PMID: 30664937 Free PMC article. Review.

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Zika Virus: Origins, Pathological Action, and Treatment Strategies.

Gorshkov K, Shiryaev SA, Fertel S, Lin YW, Huang CT, Pinto A, Farhy C, Strongin AY, Zheng W, Terskikh AV. Gorshkov K, et al. Front Microbiol. 2019 Jan 7;9:3252. doi: 10.3389/fmicb.2018.03252. eCollection 2018. Front Microbiol. 2019. PMID: 30666246 Free PMC article. Review.

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A SARS-CoV-2 nucleocapsid protein TR-FRET assay amenable to high-throughput screening.

Gorshkov K, Vasquez DM, Chiem K, Ye C, Tran BN, de la Torre JC, Moran T, Chen CZ, Martinez-Sobrido L, Zheng W. Gorshkov K, et al. bioRxiv. 2021 Jul 5:2021.07.03.450938. doi: 10.1101/2021.07.03.450938. Preprint. bioRxiv. 2021. PMID: 34268508 Free PMC article. Updated.

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