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104 results

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Page 1
GPC6 Promotes Cell Proliferation, Migration, and Invasion in Nasopharyngeal Carcinoma.
Fan C, Tu C, Qi P, Guo C, Xiang B, Zhou M, Li X, Wu X, Li X, Li G, Xiong W, Zeng Z. Fan C, et al. J Cancer. 2019 Jun 24;10(17):3926-3932. doi: 10.7150/jca.31345. eCollection 2019. J Cancer. 2019. PMID: 31417636 Free PMC article.
Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the present study, we verified this finding and conducted a series of functional experiments, which demonstrated that GPC6 promotes the mi …
Of the resultantly identified variations, glypican-6 (GPC6), was shown, for the first time, to be frequently mutated in NPC. In the p …
Five siblings expand the spectrum of GPC6-related skeletal dysplasia.
Crenshaw MM, Meyers ML, Brown K, Slegesky V, Duis J, Elias ER, Saenz M, Shi W, Filmus J, Meeks NJL. Crenshaw MM, et al. Am J Med Genet A. 2023 Oct;191(10):2571-2577. doi: 10.1002/ajmg.a.63337. Epub 2023 Jun 23. Am J Med Genet A. 2023. PMID: 37353964
Omodysplasia-1 is a type of skeletal dysplasia caused by biallelic loss of function variants in the GPC6 gene. GPC6 codes for the protein glypican 6 (GPC6) (OMIM *604404), which stimulates bone growth. ...Given the unique phenotype and molecular mechanism, we …
Omodysplasia-1 is a type of skeletal dysplasia caused by biallelic loss of function variants in the GPC6 gene. GPC6 codes for …
PFKP and GPC6 Variants Were Correlated with Alcohol-Induced Femoral Head Necrosis Risk in the Chinese Han Population.
Liu C, Liu X, Li X. Liu C, et al. Pharmgenomics Pers Med. 2022 Sep 9;15:797-808. doi: 10.2147/PGPM.S369957. eCollection 2022. Pharmgenomics Pers Med. 2022. PMID: 36110408 Free PMC article.
RESULTS: The overall analysis showed that PFKP rs10903966 and GPC6 rs7320969 were correlated with AIONFH risk. GPC6 rs4773724 was associated with a reduced risk of AIONFH, while individuals with GPC6 rs9523981 CC genotype had a higher risk of AIONFH than indi …
RESULTS: The overall analysis showed that PFKP rs10903966 and GPC6 rs7320969 were correlated with AIONFH risk. GPC6 rs4773724 …
Glypicans.
Filmus J, Capurro M, Rast J. Filmus J, et al. Genome Biol. 2008;9(5):224. doi: 10.1186/gb-2008-9-5-224. Epub 2008 May 22. Genome Biol. 2008. PMID: 18505598 Free PMC article. Review.
There are six family members in mammals (GPC1 to GPC6). Glypicans can be released from the cell surface by a lipase called Notum, and most of them are subjected to endoproteolytic cleavage by furin-like convertases. ...
There are six family members in mammals (GPC1 to GPC6). Glypicans can be released from the cell surface by a lipase called Notum, and …
Wnt3a-Loaded Extracellular Vesicles Promote Alveolar Epithelial Regeneration after Lung Injury.
Gao L, Sun Y, Zhang X, Ma D, Xie A, Wang E, Cheng L, Liu S. Gao L, et al. Adv Sci (Weinh). 2023 Jun;10(18):e2206606. doi: 10.1002/advs.202206606. Epub 2023 Apr 18. Adv Sci (Weinh). 2023. PMID: 37072558 Free PMC article.
The newly engineered Wnt3a(WG) EVs are generated by co-expressing Wnt3a with two genes encoding the membrane protein, WLS, and an engineered glypican, GPC6(deltaGPI) -C1C2. The bioactivity of Wnt3a(WG) EVs is validated using a TOPFlash assay and a mesoderm differentiation …
The newly engineered Wnt3a(WG) EVs are generated by co-expressing Wnt3a with two genes encoding the membrane protein, WLS, and an engineered …
GPC6, a novel member of the glypican gene family, encodes a product structurally related to GPC4 and is colocalized with GPC5 on human chromosome 13.
Paine-Saunders S, Viviano BL, Saunders S. Paine-Saunders S, et al. Genomics. 1999 May 1;57(3):455-8. doi: 10.1006/geno.1999.5793. Genomics. 1999. PMID: 10329016
This cDNA encodes a predicted protein of 554 amino acids and is structurally analogous to other members of the glypican gene family, but most highly related to glypican-4. A single GPC6 mRNA of 6.2 kb is detected most abundantly in the ovary, liver, and kidney, with lower …
This cDNA encodes a predicted protein of 554 amino acids and is structurally analogous to other members of the glypican gene family, but mos …
Glypican-6 and Glypican-4 stimulate embryonic stomach growth by regulating Hedgehog and noncanonical Wnt signaling.
Shi W, Filmus J. Shi W, et al. Dev Dyn. 2022 Dec;251(12):2015-2028. doi: 10.1002/dvdy.533. Epub 2022 Sep 16. Dev Dyn. 2022. PMID: 36057966 Free article.
The mammalian genome contains six glypicans (GPC1 to GPC6). GPC6 and GPC4 are the pair of glypicans that show the highest degree of homology within the family. GPC6-null embryos display bone abnormalities and severely shortened intestines. RESULTS: We show th …
The mammalian genome contains six glypicans (GPC1 to GPC6). GPC6 and GPC4 are the pair of glypicans that show the highest degr …
Overexpression of GPC6 and TMEM132D in Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival.
Karapetsas A, Giannakakis A, Dangaj D, Lanitis E, Kynigopoulos S, Lambropoulou M, Tanyi JL, Galanis A, Kakolyris S, Trypsianis G, Coukos G, Sandaltzopoulos R. Karapetsas A, et al. Biomed Res Int. 2015;2015:712438. doi: 10.1155/2015/712438. Epub 2015 Sep 13. Biomed Res Int. 2015. PMID: 26448945 Free PMC article.
GPC6 and TMEM132D expression was also documented in a variety of ovarian cancer cell lines. Importantly, Kaplan-Meier survival analysis revealed that high mRNA levels of GPC6 and/or TMEM132D correlated significantly with increased overall survival of early stage ova …
GPC6 and TMEM132D expression was also documented in a variety of ovarian cancer cell lines. Importantly, Kaplan-Meier survival analys …
TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6.
Lehmkuhl EM, Loganathan S, Alsop E, Blythe AD, Kovalik T, Mortimore NP, Barrameda D, Kueth C, Eck RJ, Siddegowda BB, Joardar A, Ball H, Macias ME, Bowser R, Van Keuren-Jensen K, Zarnescu DC. Lehmkuhl EM, et al. Acta Neuropathol Commun. 2021 Mar 24;9(1):52. doi: 10.1186/s40478-021-01148-z. Acta Neuropathol Commun. 2021. PMID: 33762006 Free PMC article.
Among these, dlp mRNA, which encodes the glypican Dally like protein (Dlp)/GPC6, a wingless (Wg/Wnt) signaling regulator is insolubilized both in flies and patient tissues with TDP-43 pathology. ...These findings together with genetic interaction data show that Dlp/GPC6 …
Among these, dlp mRNA, which encodes the glypican Dally like protein (Dlp)/GPC6, a wingless (Wg/Wnt) signaling regulator is insolubil …
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis.
Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, Obisesan TO, Kamboh MI, Bennett DA, Hall KS, Goate AM, Foroud TM, Martin ER, Wang LS, Byrd GS, Farrer LA, Haines JL, Schellenberg GD, Mayeux R, Pericak-Vance MA, Reitz C; Writing Group for the Alzheimer’s Disease Genetics Consortium (ADGC); Graff-Radford NR, Martinez I, Ayodele T, Logue MW, Cantwell LB, Jean-Francois M, Kuzma AB, Adams LD, Vance JM, Cuccaro ML, Chung J, Mez J, Lunetta KL, Jun GR, Lopez OL, Hendrie HC, Reiman EM, Kowall NW, Leverenz JB, Small SA, Levey AI, Golde TE, Saykin AJ, Starks TD, Albert MS, Hyman BT, Petersen RC, Sano M, Wisniewski T, Vassar R, Kaye JA, Henderson VW, DeCarli C, LaFerla FM, Brewer JB, Miller BL, Swerdlow RH, Van Eldik LJ, Paulson HL, Trojanowski JQ, Chui HC, Rosenberg RN, Craft S, Grabowski TJ, Asthana S, Morris JC, Strittmatter SM, Kukull WA. Kunkle BW, et al. JAMA Neurol. 2021 Jan 1;78(1):102-113. doi: 10.1001/jamaneurol.2020.3536. JAMA Neurol. 2021. PMID: 33074286 Free PMC article.
Associations with 4 novel common loci centered near the intracellular glycoprotein trafficking gene EDEM1 (3p26; P = 8.9 10-7), near the immune response gene ALCAM (3q13; P = 9.3 10-7), within GPC6 (13q31; P = 4.1 10-7), a gene critical for recruitment of glutamatergic rec …
Associations with 4 novel common loci centered near the intracellular glycoprotein trafficking gene EDEM1 (3p26; P = 8.9 10-7), near the imm …
104 results