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GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models.
Torphy RJ, Sun Y, Lin R, Caffrey-Carr A, Fujiwara Y, Ho F, Miller EN, McCarter MD, Lyons TR, Schulick RD, Kedl RM, Zhu Y. Torphy RJ, et al. Nat Commun. 2022 Jan 10;13(1):97. doi: 10.1038/s41467-021-27658-x. Nat Commun. 2022. PMID: 35013216 Free PMC article.
In GPR182-deficient mice, T cell infiltration into transplanted melanomas increases, leading to enhanced effector T cell function and improved antitumor immunity. ...CXCR3 blockade reverses the improved antitumor immunity and T cell infiltration characteristic of GPR182
In GPR182-deficient mice, T cell infiltration into transplanted melanomas increases, leading to enhanced effector T cell function and …
GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity.
Melgrati S, Gerken OJ, Artinger M, Radice E, Szpakowska M, Chevigné A, D'Uonnolo G, Antonello P, Thelen S, Pelczar P, Legler DF, Thelen M. Melgrati S, et al. Front Immunol. 2023 Jul 24;14:1242531. doi: 10.3389/fimmu.2023.1242531. eCollection 2023. Front Immunol. 2023. PMID: 37554323 Free PMC article.
We also reveal that CXCL13 and CCL28, which do not bind any other ACKR, are bound and efficiently scavenged by GPR182. Moreover, we found a cooperative relationship between GPR182 and ACKR3 in regulating serum CXCL12 levels, and between GPR182 and ACKR4 in co …
We also reveal that CXCL13 and CCL28, which do not bind any other ACKR, are bound and efficiently scavenged by GPR182. Moreover, we f …
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jäger Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Adams R, Schroeder T, Rieger MA, Offermanns S. Le Mercier A, et al. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2021596118. doi: 10.1073/pnas.2021596118. Proc Natl Acad Sci U S A. 2021. PMID: 33875597 Free PMC article.
G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological role has remained elusive. ...In constitutive GPR182-deficient mice, as well as after induced endothelium-specific loss of GPR182
G protein-coupled receptor 182 (GPR182) has been shown to be expressed in endothelial cells; however, its ligand and physiological ro …
Orphan Gpr182 suppresses ERK-mediated intestinal proliferation during regeneration and adenoma formation.
Kechele DO, Blue RE, Zwarycz B, Espenschied ST, Mah AT, Siegel MB, Perou CM, Ding S, Magness ST, Lund PK, Caron KM. Kechele DO, et al. J Clin Invest. 2017 Feb 1;127(2):593-607. doi: 10.1172/JCI87588. Epub 2017 Jan 17. J Clin Invest. 2017. PMID: 28094771 Free PMC article.
In the ApcMin mouse model, which forms spontaneous intestinal adenomas, reductions in Gpr182 led to more adenomas and decreased survival. Loss of Gpr182 enhanced organoid growth efficiency ex vivo in an EGF-dependent manner. ...Importantly, GPR182 expression …
In the ApcMin mouse model, which forms spontaneous intestinal adenomas, reductions in Gpr182 led to more adenomas and decreased survi …
GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.
Schmid CD, Schledzewski K, Mogler C, Waldburger N, Kalna V, Marx A, Randi AM, Géraud C, Goerdt S, Koch PS. Schmid CD, et al. Biochem Biophys Res Commun. 2018 Feb 26;497(1):32-38. doi: 10.1016/j.bbrc.2018.01.185. Epub 2018 Feb 1. Biochem Biophys Res Commun. 2018. PMID: 29408502 Free article.
Loss of endothelial GPR182 expression was also seen in fibrotic and cirrhotic liver tissues. ...Whereas ERK and RhoA signaling were inhibited, CREB and Calcium signaling were activated by ectopic GPR182 overexpression. Our data demonstrate that GPR182 is an e …
Loss of endothelial GPR182 expression was also seen in fibrotic and cirrhotic liver tissues. ...Whereas ERK and RhoA signaling were i …
Atypical chemokine receptors: emerging therapeutic targets in cancer.
Torphy RJ, Yee EJ, Schulick RD, Zhu Y. Torphy RJ, et al. Trends Pharmacol Sci. 2022 Dec;43(12):1085-1097. doi: 10.1016/j.tips.2022.09.009. Epub 2022 Oct 26. Trends Pharmacol Sci. 2022. PMID: 36307250 Free PMC article. Review.
Additionally, recent research has expanded our understanding of the function of several receptors including GPR182, CCRL2, GPR1, PITPNM3, and C5aR2 that share similarities with the ACKR family. ...
Additionally, recent research has expanded our understanding of the function of several receptors including GPR182, CCRL2, GPR1, PITP …
Large chemokine binding spectrum of human and mouse atypical chemokine receptor GPR182 (ACKR5).
Bonnavion R, Liu S, Kawase H, Roquid KA, Offermanns S. Bonnavion R, et al. Front Pharmacol. 2023 Nov 1;14:1297596. doi: 10.3389/fphar.2023.1297596. eCollection 2023. Front Pharmacol. 2023. PMID: 38026988 Free PMC article.
In line with the binding affinity observed in vitro, elevated serum levels of CCL22, CCL24, CCL25, and CCL27 were observed in GPR182-deficient mice, underscoring the role of GPR182 in chemokine scavenging. These data show a broader chemokine binding repertoire of …
In line with the binding affinity observed in vitro, elevated serum levels of CCL22, CCL24, CCL25, and CCL27 were observed in GPR182- …
Atlas of the anatomical localization of atypical chemokine receptors in healthy mice.
Melgrati S, Radice E, Ameti R, Hub E, Thelen S, Pelczar P, Jarrossay D, Rot A, Thelen M. Melgrati S, et al. PLoS Biol. 2023 May 9;21(5):e3002111. doi: 10.1371/journal.pbio.3002111. eCollection 2023 May. PLoS Biol. 2023. PMID: 37159457 Free PMC article.
ACKR4, which binds and scavenges CCL19, CCL20, CCL21, CCL22, and CCL25, has also been detected in lymphatic and blood vessels of secondary lymphoid organs, where it clears chemokines to facilitate cell migration. Recently, GPR182, a novel ACKR-like scavenger receptor, has …
ACKR4, which binds and scavenges CCL19, CCL20, CCL21, CCL22, and CCL25, has also been detected in lymphatic and blood vessels of secondary l …
New pairings and deorphanization among the atypical chemokine receptor family - physiological and clinical relevance.
Szpakowska M, D'Uonnolo G, Luís R, Alonso Bartolomé A, Thelen M, Legler DF, Chevigné A. Szpakowska M, et al. Front Immunol. 2023 Apr 20;14:1133394. doi: 10.3389/fimmu.2023.1133394. eCollection 2023. Front Immunol. 2023. PMID: 37153591 Free PMC article. Review.
Recently, targeted approaches and screening programs aiming at reassessing chemokine activity towards ACKRs identified several new pairings such as the dimeric CXCL12 with ACKR1, CXCL2, CXCL10 and CCL26 with ACKR2, the viral broad-spectrum chemokine vCCL2/vMIP-II, a range of opio …
Recently, targeted approaches and screening programs aiming at reassessing chemokine activity towards ACKRs identified several new pairings …
The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling.
Kwon HB, Mackie DI, Bonnavion R, Mercier AL, Helker CSM, Son T, Guenter S, Serafin DS, Kim KW, Offermanns S, Caron KM, Stainier DYR. Kwon HB, et al. ACS Pharmacol Transl Sci. 2020 Jun 24;3(4):676-689. doi: 10.1021/acsptsci.0c00020. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832870 Free PMC article.
However, the physiological role and molecular mechanism of action of GPR182 are unknown. Here, we show that GPR182 negatively regulates definitive hematopoiesis in zebrafish and mice. ...GPR182 (-/-) mice also exhibit an increased number of myeloid cells comp …
However, the physiological role and molecular mechanism of action of GPR182 are unknown. Here, we show that GPR182 negatively …
16 results