Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1997 1
2008 1
2015 2
2016 1
2017 1
2020 1
2021 2
2023 3
2024 2
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

12 results

Results by year

Filters applied: . Clear all
Page 1
Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody-Drug Conjugate.
Iida K, Abdelhamid Ahmed AH, Nagatsuma AK, Shibutani T, Yasuda S, Kitamura M, Hattori C, Abe M, Hasegawa J, Iguchi T, Karibe T, Nakada T, Inaki K, Kamei R, Abe Y, Nomura T, Andersen JL, Santagata S, Hemming ML, George S, Doi T, Ochiai A, Demetri GD, Agatsuma T. Iida K, et al. Cancer Discov. 2021 Jun;11(6):1508-1523. doi: 10.1158/2159-8290.CD-20-1434. Epub 2021 Feb 12. Cancer Discov. 2021. PMID: 33579785 Clinical Trial.
Herein, we identified G protein-coupled receptor 20 (GPR20) as a novel non-tyrosine kinase target in GIST, developed new GPR20 IHC, and assessed GPR20 expression in cell lines, patient-derived xenografts, and clinical samples from two institutes (United State …
Herein, we identified G protein-coupled receptor 20 (GPR20) as a novel non-tyrosine kinase target in GIST, developed new GPR20 …
Upregulation of Siglec-6 induces mitochondrial dysfunction by promoting GPR20 expression in early-onset preeclampsia.
Jia Y, Lu W, Xie H, Sheng Y, Wang L, Lv W, Ling L, Dong J, Jia X, Wu S, Liu W, Ying H. Jia Y, et al. J Transl Med. 2024 Jul 22;22(1):674. doi: 10.1186/s12967-024-05505-z. J Transl Med. 2024. PMID: 39039496 Free PMC article.
Mechanismly, Siglec-6 inhibits the activation of NF-kappaB by recruiting SHP1/SHP2, leading to increased expression of GPR20. Notably, the importance of GPR20 function downstream of Siglec-6 in trophoblasts is supported by the observation that GPR20 downregul …
Mechanismly, Siglec-6 inhibits the activation of NF-kappaB by recruiting SHP1/SHP2, leading to increased expression of GPR20. Notably …
The activation mechanism and antibody binding mode for orphan GPR20.
Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F. Lin X, et al. Cell Discov. 2023 Feb 28;9(1):23. doi: 10.1038/s41421-023-00520-8. Cell Discov. 2023. PMID: 36849514 Free PMC article.
Here we report three cryo-EM structures of human GPR20 complexes including Gi-coupled GPR20 in the absence or presence of the Fab fragment of Ab046 and Gi-free GPR20. Remarkably, the structures demonstrate a uniquely folded N-terminal helix capping onto the t …
Here we report three cryo-EM structures of human GPR20 complexes including Gi-coupled GPR20 in the absence or presence of the …
Exploring the constitutive activation mechanism of the class A orphan GPR20.
Zhang MY, Ao JY, Liu N, Chen T, Lu SY. Zhang MY, et al. Acta Pharmacol Sin. 2025 Feb;46(2):500-511. doi: 10.1038/s41401-024-01385-7. Epub 2024 Sep 10. Acta Pharmacol Sin. 2025. PMID: 39256608
GPR20, an orphan G protein-coupled receptor (GPCR), shows significant expression in intestinal tissue and represents a potential therapeutic target to treat gastrointestinal stromal tumors. ...Moreover, the constitutively active state of the GPR20 requires both the …
GPR20, an orphan G protein-coupled receptor (GPCR), shows significant expression in intestinal tissue and represents a potential ther …
Constitutive Activity among Orphan Class-A G Protein Coupled Receptors.
Martin AL, Steurer MA, Aronstam RS. Martin AL, et al. PLoS One. 2015 Sep 18;10(9):e0138463. doi: 10.1371/journal.pone.0138463. eCollection 2015. PLoS One. 2015. PMID: 26384023 Free PMC article.
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20, GPR25, GPR27, GPR31, GPR32, GPR45, GPR57, GPR68, GPR83, GPR84, GPR132, GPR150, GPR176); 2) no effect on baseline expression, but inhibit …
Five patterns of activity were noted: 1) inhibition under both baseline and forskolin stimulated expression (GPR15, GPR17, GPR18, GPR20 …
Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins.
Hase M, Yokomizo T, Shimizu T, Nakamura M. Hase M, et al. J Biol Chem. 2008 May 9;283(19):12747-55. doi: 10.1074/jbc.M709487200. Epub 2008 Mar 17. J Biol Chem. 2008. PMID: 18347022 Free article.
Knockdown of GPR20 in PC12h cells resulted in an elevation of the basal cAMP level, suggesting that the endogenous GPR20 achieves a constitutively or spontaneously active conformation. Furthermore, enhancement of [(3)H]thymidine incorporation was also observed in th …
Knockdown of GPR20 in PC12h cells resulted in an elevation of the basal cAMP level, suggesting that the endogenous GPR20 achie …
G protein-coupled receptors: Key molecules in metabolic associated fatty liver disease development.
López-Méndez I, Méndez-Maldonado K, Manzo-Francisco LA, Juárez-Hernández E, Uribe M, Barbero-Becerra VJ. López-Méndez I, et al. Nutr Res. 2021 Mar;87:70-79. doi: 10.1016/j.nutres.2020.12.019. Epub 2020 Dec 24. Nutr Res. 2021. PMID: 33601216 Review.
The expression of GPRs is associated with obesity, microbiota environment, and dietary characteristics in patients with MAFLD. More specifically, GPR41, GPR43, GPR20, and GPR120 have been associated with alteration of lipid metabolism in hepatic and intestinal cells, and c …
The expression of GPRs is associated with obesity, microbiota environment, and dietary characteristics in patients with MAFLD. More specific …
A Phase I, Multicenter, Open-Label, First-in-Human Study of DS-6157a in Patients with Advanced Gastrointestinal Stromal Tumor.
George S, Heinrich MC, Somaiah N, Oppelt P, McLeod R, Nishioka S, Kundu MG, Qian X, Kumar P, Laadem A, Lau Y, Tran BP, Fallon M, Dosunmu O, Shi J, Naito Y. George S, et al. Clin Cancer Res. 2023 Sep 15;29(18):3659-3667. doi: 10.1158/1078-0432.CCR-23-0640. Clin Cancer Res. 2023. PMID: 37363962 Free PMC article.
Plasma concentrations and exposure of intact DS-6157a, DXd, and total anti-GPR20 antibody all demonstrated a dose-dependent profile. No treatment-emergent ADAs were observed. CONCLUSIONS: Targeting GPR20 with DS-6157a was tolerated in patients with advanced GIST wit …
Plasma concentrations and exposure of intact DS-6157a, DXd, and total anti-GPR20 antibody all demonstrated a dose-dependent profile. …
APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease.
Vélez JI, Lopera F, Sepulveda-Falla D, Patel HR, Johar AS, Chuah A, Tobón C, Rivera D, Villegas A, Cai Y, Peng K, Arkell R, Castellanos FX, Andrews SJ, Silva Lara MF, Creagh PK, Easteal S, de Leon J, Wong ML, Licinio J, Mastronardi CA, Arcos-Burgos M. Vélez JI, et al. Mol Psychiatry. 2016 Jul;21(7):916-24. doi: 10.1038/mp.2015.177. Epub 2015 Dec 1. Mol Psychiatry. 2016. PMID: 26619808 Free PMC article.
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferation, protein degradation, apoptotic and immune dysregulation processes (i.e., GPR20, TRIM22, FCRL5, AOAH, PINLYP, IFI16, RC3H1 and DFN …
Exploratory linear mixed-effects multilocus analysis suggested that other functional variants harbored in genes involved in cell proliferati …
Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes.
O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF Jr, Lynch KR, George SR. O'Dowd BF, et al. Gene. 1997 Mar 10;187(1):75-81. doi: 10.1016/s0378-1119(96)00722-6. Gene. 1997. PMID: 9073069
Northern blot analysis revealed expression of GPR20 and GPR22 in several human brain regions while GPR20 expression was detected also in liver. Fluorescence in situ hybridization (FISH) was used to map GPR20 to chromosome 8q, region 24.3-24.2, GPR21 to chromo …
Northern blot analysis revealed expression of GPR20 and GPR22 in several human brain regions while GPR20 expression was detect …
12 results