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GPR50 Distribution in the Mouse Cortex and Hippocampus.
Li Q, Zhang Y, Ge BY, Li N, Sun HL, Ntim M, Sun YP, Wu XF, Yang JY, Li S. Li Q, et al. Neurochem Res. 2020 Oct;45(10):2312-2323. doi: 10.1007/s11064-020-03089-w. Epub 2020 Jul 21. Neurochem Res. 2020. PMID: 32696324
But, the distribution of GPR50 in the hippocampus and cortex and the cell types expressing GPR50 is not yet clear. ...Besides, similar results were seen in the cortex. The widespread expression of GPR50 in the hippocampus and cortex suggests that GPR50
But, the distribution of GPR50 in the hippocampus and cortex and the cell types expressing GPR50 is not yet clear. ...Besides, …
GPR50 participates in and promotes yak oocyte maturation: A new potential oocyte regulatory molecule.
Chen Y, Zeng R, Kou J, Xiong X, Yao Y, Fu W, Yin S, Lan D. Chen Y, et al. Theriogenology. 2022 Mar 15;181:34-41. doi: 10.1016/j.theriogenology.2022.01.009. Epub 2022 Jan 12. Theriogenology. 2022. PMID: 35063919
GPR50 has been recently proved to play an important role in various physiological activities. However, the role of GPR50 in reproduction is currently unclear. In our previous research, we proved that the GPR50 receptor is present in yak oocytes. ...
GPR50 has been recently proved to play an important role in various physiological activities. However, the role of GPR50 in re
GPR50 in TGFbeta signaling and breast cancer.
Ahmad R, Wojciech S, Jockers R. Ahmad R, et al. Oncoscience. 2018 Jun 27;5(5-6):157-158. doi: 10.18632/oncoscience.433. eCollection 2018 May. Oncoscience. 2018. PMID: 30035175 Free PMC article. No abstract available.
High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells in vitro.
Zhao W, Xi L, Yu G, Wang G, Chang C. Zhao W, et al. J Cell Commun Signal. 2023 Dec;17(4):1435-1447. doi: 10.1007/s12079-023-00772-9. Epub 2023 Jun 28. J Cell Commun Signal. 2023. PMID: 37378811 Free PMC article.
Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation, migration, and autophagy of CBRH-7919. ...Taken together, GPR50 may promote HCC progression via CCT6A-induced proliferation and PGK1-induced migration
Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation, migration, and au
The emerging role of GPR50 receptor in brain.
Khan MZ, He L, Zhuang X. Khan MZ, et al. Biomed Pharmacother. 2016 Mar;78:121-128. doi: 10.1016/j.biopha.2016.01.003. Epub 2016 Jan 24. Biomed Pharmacother. 2016. PMID: 26898433 Review.
GPR50 receptor one of the member of G protein-coupled receptors (GPCRs) is extensively expressed in the pituitary, hypothalamus,cortex, midbrain, pons, amygdala, and in several brainstem nuclei. ...Although the results are encouraging, further research is needed to clarify
GPR50 receptor one of the member of G protein-coupled receptors (GPCRs) is extensively expressed in the pituitary, hypothalamus,corte
Orphan receptor GPR50 attenuates inflammation and insulin signaling in 3T3-L1 preadipocytes.
Yao Z, Meng J, Long J, Li L, Qiu W, Li C, Zhang JV, Ren PG. Yao Z, et al. FEBS Open Bio. 2023 Jan;13(1):89-101. doi: 10.1002/2211-5463.13516. Epub 2022 Dec 13. FEBS Open Bio. 2023. PMID: 36333974 Free PMC article.
GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency increased inflammation in 3T3-L1 cells and induced the phosphorylation of AKT and insulin receptor substrate (IRS) 1. Furthermore, GPR50
GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice, while GPR50 deficiency i
The orphan GPR50 receptor interacting with TbetaRI induces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells.
Chang C, Wang D, Xi L, Guo X, Wang G, Yu G. Chang C, et al. Biochem Pharmacol. 2022 Aug;202:115117. doi: 10.1016/j.bcp.2022.115117. Epub 2022 Jun 6. Biochem Pharmacol. 2022. PMID: 35671788
However, little research has been done on the regulation and mechanism of GPR50 in the liver. Herein, we observed that the overexpression of GPR50 inhibited the proliferation of BRL-3A cells. To further explore the molecular mechanisms of GPR50 in the regulat …
However, little research has been done on the regulation and mechanism of GPR50 in the liver. Herein, we observed that the overexpres …
GPR50 Promotes Hepatocellular Carcinoma Progression via the Notch Signaling Pathway through Direct Interaction with ADAM17.
Saha SK, Choi HY, Yang GM, Biswas PK, Kim K, Kang GH, Gil M, Cho SG. Saha SK, et al. Mol Ther Oncolytics. 2020 Apr 14;17:332-349. doi: 10.1016/j.omto.2020.04.002. eCollection 2020 Jun 26. Mol Ther Oncolytics. 2020. PMID: 32405532 Free PMC article.
GPR50 silencing also downregulated transcription and translation of ADAM17 through the AKT/specificity protein-1 (SP1) signaling axis. Notably, GPR50 was found to directly interact with ADAM17. Overall, we demonstrate a novel GPR50-mediated regulation of the
GPR50 silencing also downregulated transcription and translation of ADAM17 through the AKT/specificity protein-1 (SP1) signaling axis
Significant association between GPR50 hypomethylation and AD in males.
Chen W, Ji H, Li L, Xu C, Zou T, Cui W, Xu S, Zhou X, Duan S, Wang Q. Chen W, et al. Mol Med Rep. 2019 Aug;20(2):1085-1092. doi: 10.3892/mmr.2019.10366. Epub 2019 Jun 6. Mol Med Rep. 2019. PMID: 31173244 Free PMC article.
Alzheimer's disease (AD) is a chronic neurodegenerative disease. G protein coupled receptor 50 (GPR50) is a candidate gene for AD. The present study was designed to determine the association between GPR50 methylation and AD. ...This may be explained by the fact that …
Alzheimer's disease (AD) is a chronic neurodegenerative disease. G protein coupled receptor 50 (GPR50) is a candidate gene for AD. Th …
GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.
Ahmad R, Lahuna O, Sidibe A, Daulat A, Zhang Q, Luka M, Guillaume JL, Gallet S, Guillonneau F, Hamroune J, Polo S, Prévot V, Delagrange P, Dam J, Jockers R. Ahmad R, et al. Cell Mol Life Sci. 2020 Dec;77(24):5189-5205. doi: 10.1007/s00018-019-03440-7. Epub 2020 Jan 3. Cell Mol Life Sci. 2020. PMID: 31900622 Free PMC article.
Here, we report an alternative signal transduction mode used by the orphan GPR50 that relies on the nuclear translocation of its carboxyl-terminal domain (CTD). Activation of the calcium-dependent calpain protease cleaves off the CTD from the transmembrane-bound GPR50
Here, we report an alternative signal transduction mode used by the orphan GPR50 that relies on the nuclear translocation of its carb …
89 results