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340 results

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Page 1
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism.
Baytas O, Davidson SM, Kauer JA, Morrow EM. Baytas O, et al. Mol Brain. 2024 Nov 27;17(1):87. doi: 10.1186/s13041-024-01154-x. Mol Brain. 2024. PMID: 39604975 Free PMC article.
GPT2 catalyzes a reversible reaction interconverting glutamate and pyruvate with alanine and alpha-ketoglutarate, a TCA cycle intermediate; thereby, GPT2 may play an important role in linking mitochondrial tricarboxylic acid (TCA) cycle with synaptic transmission. I …
GPT2 catalyzes a reversible reaction interconverting glutamate and pyruvate with alanine and alpha-ketoglutarate, a TCA cycle interme …
GPT2 Is Induced by Hypoxia-Inducible Factor (HIF)-2 and Promotes Glioblastoma Growth.
Zhang B, Chen Y, Bao L, Luo W. Zhang B, et al. Cells. 2022 Aug 20;11(16):2597. doi: 10.3390/cells11162597. Cells. 2022. PMID: 36010673 Free PMC article.
HIF-2 directly bound to the hypoxia response element of the human GPT2 gene, leading to its transcription in hypoxic GBM cells. GPT2 located at the nucleus and mitochondria and reduced alpha-ketoglutarate levels in GBM cells. Genetic or pharmacological inhibition of …
HIF-2 directly bound to the hypoxia response element of the human GPT2 gene, leading to its transcription in hypoxic GBM cells. GP …
GPT2 mediates glutamine metabolism-driven metabolic alterations in platinum-resistant ovarian cancer cells.
Ponton-Almodovar A, Udumula MP, Khullar V, Rashid F, Rattan R, Bernard JJ, Horibata S. Ponton-Almodovar A, et al. Sci Rep. 2025 Aug 20;15(1):30528. doi: 10.1038/s41598-025-15707-0. Sci Rep. 2025. PMID: 40835655 Free PMC article.
Key enzymes involved in glutaminolysis, specifically, glutamic-pyruvic transaminase 2 (GPT2), were upregulated in chemoresistant compared to chemosensitive cells. Interestingly, high GPT2 gene expression is associated with worse prognosis in ovarian cancer patients, …
Key enzymes involved in glutaminolysis, specifically, glutamic-pyruvic transaminase 2 (GPT2), were upregulated in chemoresistant comp …
Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.
Cui M, Peng J, Zhou Y, Wang X, Cui D. Cui M, et al. Thorac Cancer. 2023 Jul;14(21):2018-2025. doi: 10.1111/1759-7714.14984. Epub 2023 Jun 7. Thorac Cancer. 2023. PMID: 37287397 Free PMC article.
BACKGROUND: There have been reports of increased glutamate pyruvate transaminase 2 (GPT2) expression in certain cancers including breast cancer. Although the role of GPT2 as a metabolic enzyme is well understood in breast cancer progression, little is known about th …
BACKGROUND: There have been reports of increased glutamate pyruvate transaminase 2 (GPT2) expression in certain cancers including bre …
The Ku70-SIX1-GPT2 axis regulates alpha-ketoglutarate metabolism to drive progression of prostate cancer.
Huang H, Zhuang X, Yin S, Sun W, Cheng J, Peng EY, Xiang Y, He X, Tang M, Li Y, Yao Y, Deng Y, Liu Q, Shao Z, Xia X, Cai G, Liao Y. Huang H, et al. Oncogene. 2025 Jan;44(2):92-104. doi: 10.1038/s41388-024-03209-8. Epub 2024 Nov 2. Oncogene. 2025. PMID: 39488663
Further studies revealed that SIX1 is recruited to the promoter region on glutamate-pyruvate transaminase 2 (GPT2). Ku70 enhances the SIX1-mediated transcriptional activation on GPT2, thereby facilitating the generation of alpha-ketoglutarate (alpha-KG). In addition …
Further studies revealed that SIX1 is recruited to the promoter region on glutamate-pyruvate transaminase 2 (GPT2). Ku70 enhances the …
Loss of mitochondrial enzyme GPT2 causes early neurodegeneration in locus coeruleus.
Baytas O, Kauer JA, Morrow EM. Baytas O, et al. Neurobiol Dis. 2022 Oct 15;173:105831. doi: 10.1016/j.nbd.2022.105831. Epub 2022 Jul 28. Neurobiol Dis. 2022. PMID: 35908744 Free PMC article.
Here we report a novel mechanism of degeneration of LC neurons caused by loss of the mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2). GPT2 Deficiency is a newly-recognized childhood neurometabolic disorder. The GPT2 enzyme regulates cell growth …
Here we report a novel mechanism of degeneration of LC neurons caused by loss of the mitochondrial enzyme glutamate pyruvate transaminase 2 …
GPT2-mediated Glutamate to alpha-Ketoglutaric Acid Conversion in Cardiac Fibroblast Promotes Fibrosis.
Chen Y, Liao F, Wang J, Zhao J, Xu Y, Chen Q, Hong T, Lv K, Li Q, Chen X, Xiao C, Wang L, Li G, Ke C, Cai J, Li J, Sheng S, Wang J, Wu X, Ruan Y, Zhang F, Wu R, Xu Y, Zhu W, Xu Y, Wang J, Ni C, Hu X. Chen Y, et al. JACC Basic Transl Sci. 2026 Apr;11(4):101518. doi: 10.1016/j.jacbts.2026.101518. Epub 2026 Mar 25. JACC Basic Transl Sci. 2026. PMID: 41880732 Free PMC article.
Inhibiting GPT2 via microRNA-30c-5p delivered by mesenchymal stem cell-derived extracellular vesicles -reduces fibrosis in both mice and human cells. GPT2 inhibition also works in other organs, suggesting broad therapeutic potential....
Inhibiting GPT2 via microRNA-30c-5p delivered by mesenchymal stem cell-derived extracellular vesicles -reduces fibrosis in both mice …
Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism.
Baytas O, Davidson SM, Kauer JA, Morrow EM. Baytas O, et al. bioRxiv [Preprint]. 2024 Nov 7:2024.11.06.622291. doi: 10.1101/2024.11.06.622291. bioRxiv. 2024. Update in: Mol Brain. 2024 Nov 27;17(1):87. doi: 10.1186/s13041-024-01154-x. PMID: 39574728 Free PMC article. Updated. Preprint.
GPT2 catalyzes a reversible reaction interconverting glutamate and pyruvate with alanine and alpha-ketoglutarate, a TCA cycle intermediate; thereby, GPT2 may play an important role in linking mitochondrial tricarboxylic acid (TCA) cycle with synaptic transmission. I …
GPT2 catalyzes a reversible reaction interconverting glutamate and pyruvate with alanine and alpha-ketoglutarate, a TCA cycle interme …
HBx-mediated GPT2 suppression promotes liver cancer development by downregulating ADH1A.
You H, Wang X, Liu R, Wang Y, Zhang H, Ma L, Bao E, Zhong Y, Liu X, Kong D, Pan X, Li X, Qin S, Zheng K, Li C, Tang R, Kong F. You H, et al. Cancer Biol Med. 2026 May 19;23(6):888-909. doi: 10.20892/j.issn.2095-3941.2025.0236. Cancer Biol Med. 2026. PMID: 42157526 Free PMC article.
Functionally, GPT2 loss promoted LC cell proliferation, migration, and lipid accumulation. Mechanistically, GPT2 was found to suppress the mTOR pathway by disrupting the AKT-mTOR interaction and leading to upregulation of ADH1A. ...Critically, the HBV oncoprotein HB …
Functionally, GPT2 loss promoted LC cell proliferation, migration, and lipid accumulation. Mechanistically, GPT2 was found to …
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia.
Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, Aziz T, Li H, Li J, Yang Y, Han L, Zhang S, Ma Y, Sun M, Wu H, Zhang Z, Wunderlich M, Robinson S, Braas D, Hoeve JT, Zhang B, Marcucci G, Mulloy JC, Zhou K, Tao HF, Deng X, Horne D, Wei M, Huang H, Chen J. Weng H, et al. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. doi: 10.1016/j.ccell.2022.10.004. Epub 2022 Oct 27. Cancer Cell. 2022. PMID: 36306790 Free PMC article.
IGF2BP2 promotes AML development and self-renewal of leukemia stem/initiation cells by regulating expression of critical targets (e.g., MYC, GPT2, and SLC1A5) in the glutamine metabolism pathways in an m(6)A-dependent manner. Inhibiting IGF2BP2 with our recently identified …
IGF2BP2 promotes AML development and self-renewal of leukemia stem/initiation cells by regulating expression of critical targets (e.g., MYC, …
340 results