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117 results

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GRIN3A: A biomarker associated with a cribriform pattern and poor prognosis in prostate cancer.
Bogaard M, Strømme JM, Kidd SG, Johannessen B, Bakken AC, Lothe RA, Axcrona K, Skotheim RI, Axcrona U. Bogaard M, et al. Neoplasia. 2024 Sep;55:101023. doi: 10.1016/j.neo.2024.101023. Epub 2024 Jun 29. Neoplasia. 2024. PMID: 38944914 Free PMC article.
GRIN3A was significantly higher expressed in cribriform pattern vs. NcGP4, when assessed within the same patient (n=27; p=0.005) and between different patients (n=83; p=0.001). ...GRIN3A was as well associated with biochemical recurrence (log-rank, p=0.002). In conc …
GRIN3A was significantly higher expressed in cribriform pattern vs. NcGP4, when assessed within the same patient (n=27; p=0.005) and …
Hippocampal tau-induced GRIN3A deficiency in Alzheimer's disease.
Lee SE, Park S, Kang R, Lee T, Yu WJ, Chang S, Park JC. Lee SE, et al. FEBS Open Bio. 2024 Dec;14(12):2059-2071. doi: 10.1002/2211-5463.13904. Epub 2024 Oct 13. FEBS Open Bio. 2024. PMID: 39396906 Free PMC article.
We found that glutamate ionotropic receptor NMDA-type subunit 3A (GRIN3A) and glutamate metabotropic receptor 8 (GRM8), which are related to the glutamatergic system, were the top two annotated genes and directly related to MAPT, which encodes a tau protein. ...Interesting …
We found that glutamate ionotropic receptor NMDA-type subunit 3A (GRIN3A) and glutamate metabotropic receptor 8 (GRM8), which are rel …
A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia.
Zgheib NK, El-Khoury H, Maamari D, Basbous M, Saab R, Muwakkit SA. Zgheib NK, et al. Per Med. 2021 Sep;18(5):431-439. doi: 10.2217/pme-2020-0167. Epub 2021 Aug 18. Per Med. 2021. PMID: 34406079
Conclusion: This is the first pharmacogenomics evaluation of the association between GRIN3A variants and glucocorticoid-induced osteonecrosis in Arab children. Lay abstract This study aimed at uncovering variants in the genetic material of Arab children, that might predisp …
Conclusion: This is the first pharmacogenomics evaluation of the association between GRIN3A variants and glucocorticoid-induced osteo …
Correlations between GRIN2B and GRIN3A gene polymorphisms and postpartum depressive symptoms in Chinese parturients undergoing cesarean section: A prospective cohort study.
Ping A, Yang M, Xu S, Li Q, Feng Y, Gao K, Wang S, Duan K. Ping A, et al. J Psychosom Res. 2023 May;168:111210. doi: 10.1016/j.jpsychores.2023.111210. Epub 2023 Mar 1. J Psychosom Res. 2023. PMID: 36898314
OBJECTIVE: To investigate the association of postpartum depressive symptoms (PDS) and self-harm ideation with n-methyl-d-aspartate (NMDA) receptor GRIN2B and GRIN3A gene polymorphisms and other risk factors in women undergoing cesarean section. ...Three GRIN2B SNP loci (rs …
OBJECTIVE: To investigate the association of postpartum depressive symptoms (PDS) and self-harm ideation with n-methyl-d-aspartate (NMDA) re …
GRIN3A and MAPT stimulate nerve overgrowth in macrodactyly.
Shi X, Lu L, Jin X, Liu B, Sun X, Lu L, Jiang Y. Shi X, et al. Mol Med Rep. 2016 Dec;14(6):5637-5643. doi: 10.3892/mmr.2016.5923. Epub 2016 Nov 3. Mol Med Rep. 2016. PMID: 27840953
Glutamate ionotropic receptor NMDA 3A (GRIN3A) and microtubule-associated protein tau (MAPT) were identified as important contributors in promoting nerve overgrowth. Furthermore, it was identified that GRIN3A and MAPT were regulated by the cAMP-protein kinase A and …
Glutamate ionotropic receptor NMDA 3A (GRIN3A) and microtubule-associated protein tau (MAPT) were identified as important contributor …
Demonstration of critical role of GRIN3A in nicotine dependence through both genetic association and molecular functional studies.
Chen J, Liu Q, Fan R, Han H, Yang Z, Cui W, Song G, Li MD. Chen J, et al. Addict Biol. 2020 Jan;25(1):e12718. doi: 10.1111/adb.12718. Epub 2019 Feb 11. Addict Biol. 2020. PMID: 30741440
Although various variants of GRIN3A have been associated with ND in European-American and African-American samples, no study has been reported for the association between GRIN3A and ND in Chinese Han population. ...Moreover, we demonstrated that nicotine at a concen …
Although various variants of GRIN3A have been associated with ND in European-American and African-American samples, no study has been …
Temporal Dynamics and Neuronal Specificity of Grin3a Expression in the Mouse Forebrain.
Murillo A, Navarro AI, Puelles E, Zhang Y, Petros TJ, Pérez-Otaño I. Murillo A, et al. Cereb Cortex. 2021 Mar 5;31(4):1914-1926. doi: 10.1093/cercor/bhaa330. Cereb Cortex. 2021. PMID: 33290502 Free PMC article.
Grin3a is expressed in both excitatory and inhibitory neurons, with strong mRNA levels being a distinguishing feature of somatostatin interneurons. Our study provides a comprehensive map of Grin3a distribution across the murine lifespan and paves the way for dissect …
Grin3a is expressed in both excitatory and inhibitory neurons, with strong mRNA levels being a distinguishing feature of somatostatin …
Impacts of GRIN3A, GRM6 and TPH2 genetic polymorphisms on quality of life in methadone maintenance therapy population.
Wang RY, Chen HJ, Huang CL, Wang JY, Lee TE, Lee HY, Hung CC. Wang RY, et al. PLoS One. 2018 Jul 30;13(7):e0201408. doi: 10.1371/journal.pone.0201408. eCollection 2018. PLoS One. 2018. PMID: 30059533 Free PMC article. Clinical Trial.
This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total of 319 participants were included in the study, and genotyping of GRIN3A, GRM6, and TPH2 genes was performed using the Sequenom iPLEX. …
This study investigated the associations between the GRIN3A, GRM6, and TPH2 genetic variants and QoL in the MMT population. A total o …
Roux-en-Y Gastric Bypass Improves Insulin Sensitivity in Obese Rats with Type 2 Diabetes Mellitus by Regulating the Grin3a/AMPK Signal Axis in Hypothalamic Arcuate Nucleus.
Zhang LH, Wang J, Tan BH, Yin YB, Kang YM. Zhang LH, et al. Diabetes Metab Syndr Obes. 2023 Nov 10;16:3617-3629. doi: 10.2147/DMSO.S430445. eCollection 2023. Diabetes Metab Syndr Obes. 2023. PMID: 38028990 Free PMC article.
METHODS: The obese T2DM rat model was constructed by feeding a high-fat diet and injecting streptozotocin (STZ), and treated with RYGB. Grin3a shRNA was injected into the bilateral hypothalamic arcuate nucleus (ARC) to knockdown the Grin3a expression on T2DM rats. . …
METHODS: The obese T2DM rat model was constructed by feeding a high-fat diet and injecting streptozotocin (STZ), and treated with RYGB. G …
117 results