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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 1
1977 1
1980 2
1983 2
1984 1
1986 1
1987 1
1988 1
1989 3
1991 2
1992 1
1993 1
1996 2
1997 1
1999 2
2006 1
2008 1
2009 2
2011 7
2012 7
2014 1
2015 2
2016 1
2018 1
2019 1
2023 0

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41 results

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Page 1
3-(1'-Cyclobutylspiro[4H-1,3-benzodioxine-2,4'-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazin-6-one (CEP-32215), a new wake-promoting histamine H3 antagonist/inverse agonist.
Hudkins RL, Gruner JA, Raddatz R, Mathiasen JR, Aimone LD, Marino MJ, Bacon ER, Williams M, Ator MA. Hudkins RL, et al. Among authors: gruner ja. Neuropharmacology. 2016 Jul;106:37-45. doi: 10.1016/j.neuropharm.2015.09.025. Epub 2015 Sep 21. Neuropharmacology. 2016. PMID: 26400408
3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity.
Hudkins RL, Becknell NC, Lyons JA, Aimone LD, Olsen M, Haltiwanger RC, Mathiasen JR, Raddatz R, Gruner JA. Hudkins RL, et al. Among authors: gruner ja. Eur J Med Chem. 2015 May 5;95:349-56. doi: 10.1016/j.ejmech.2015.03.054. Epub 2015 Mar 24. Eur J Med Chem. 2015. PMID: 25827402
Armodafinil promotes wakefulness and activates Fos in rat brain.
Fiocchi EM, Lin YG, Aimone L, Gruner JA, Flood DG. Fiocchi EM, et al. Among authors: gruner ja. Pharmacol Biochem Behav. 2009 May;92(3):549-57. doi: 10.1016/j.pbb.2009.02.006. Epub 2009 Feb 26. Pharmacol Biochem Behav. 2009. PMID: 19249327
Discovery of (1R,6S)-5-[4-(1-cyclobutyl-piperidin-4-yloxy)-phenyl]-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one (R,S-4a): histamine H(3) receptor inverse agonist demonstrating potent cognitive enhancing and wake promoting activity.
Hudkins RL, Josef KA, Becknell NC, Aimone LD, Lyons JA, Mathiasen JR, Gruner JA, Raddatz R. Hudkins RL, et al. Among authors: gruner ja. Bioorg Med Chem Lett. 2014 Mar 1;24(5):1303-6. doi: 10.1016/j.bmcl.2014.01.061. Epub 2014 Jan 30. Bioorg Med Chem Lett. 2014. PMID: 24513042
41 results