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Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway.
Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, Zezula J. Gsandtner I, et al. J Biol Chem. 2005 Sep 9;280(36):31898-905. doi: 10.1074/jbc.M506515200. Epub 2005 Jul 18. J Biol Chem. 2005. PMID: 16027149 Free article.