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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1981 1
1982 1
1984 6
1985 4
1988 3
1989 1
1990 5
1991 3
1992 5
1993 3
1994 8
1995 16
1996 15
1997 12
1998 21
1999 23
2000 27
2001 35
2002 44
2003 37
2004 62
2005 70
2006 59
2007 74
2008 88
2009 124
2010 137
2011 135
2012 171
2013 182
2014 226
2015 239
2016 228
2017 249
2018 306
2019 369
2020 395
2021 507
2022 280
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Search Results

3,757 results
Results by year
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Page 1
SAR1B senses leucine levels to regulate mTORC1 signalling.
Chen J, Ou Y, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen PR, Liu Y. Chen J, et al. Among authors: guan j. Nature. 2021 Aug;596(7871):281-284. doi: 10.1038/s41586-021-03768-w. Epub 2021 Jul 21. Nature. 2021. PMID: 34290409
Chemical reprogramming of human somatic cells to pluripotent stem cells.
Guan J, Wang G, Wang J, Zhang Z, Fu Y, Cheng L, Meng G, Lyu Y, Zhu J, Li Y, Wang Y, Liuyang S, Liu B, Yang Z, He H, Zhong X, Chen Q, Zhang X, Sun S, Lai W, Shi Y, Liu L, Wang L, Li C, Lu S, Deng H. Guan J, et al. Nature. 2022 May;605(7909):325-331. doi: 10.1038/s41586-022-04593-5. Epub 2022 Apr 13. Nature. 2022. PMID: 35418683
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer.
Liang J, Zbieg JR, Blake RA, Chang JH, Daly S, DiPasquale AG, Friedman LS, Gelzleichter T, Gill M, Giltnane JM, Goodacre S, Guan J, Hartman SJ, Ingalla ER, Kategaya L, Kiefer JR, Kleinheinz T, Labadie SS, Lai T, Li J, Liao J, Liu Z, Mody V, McLean N, Metcalfe C, Nannini MA, Oeh J, O'Rourke MG, Ortwine DF, Ran Y, Ray NC, Roussel F, Sambrone A, Sampath D, Schutt LK, Vinogradova M, Wai J, Wang T, Wertz IE, White JR, Yeap SK, Young A, Zhang B, Zheng X, Zhou W, Zhong Y, Wang X. Liang J, et al. Among authors: guan j. J Med Chem. 2021 Aug 26;64(16):11841-11856. doi: 10.1021/acs.jmedchem.1c00847. Epub 2021 Jul 12. J Med Chem. 2021. PMID: 34251202
Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery.
Li Y, Hou G, Zhou H, Wang Y, Tun HM, Zhu A, Zhao J, Xiao F, Lin S, Liu D, Zhou D, Mai L, Zhang L, Zhang Z, Kuang L, Guan J, Chen Q, Wen L, Zhang Y, Zhuo J, Li F, Zhuang Z, Chen Z, Luo L, Liu D, Chen C, Gan M, Zhong N, Zhao J, Ren Y, Xu Y. Li Y, et al. Among authors: guan j. Signal Transduct Target Ther. 2021 Apr 15;6(1):155. doi: 10.1038/s41392-021-00508-4. Signal Transduct Target Ther. 2021. PMID: 33859163 Free PMC article.
Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates.
Du Y, Liang Z, Wang S, Sun D, Wang X, Liew SY, Lu S, Wu S, Jiang Y, Wang Y, Zhang B, Yu W, Lu Z, Pu Y, Zhang Y, Long H, Xiao S, Liang R, Zhang Z, Guan J, Wang J, Ren H, Wei Y, Zhao J, Sun S, Liu T, Meng G, Wang L, Gu J, Wang T, Liu Y, Li C, Tang C, Shen Z, Peng X, Deng H. Du Y, et al. Among authors: guan j. Nat Med. 2022 Feb;28(2):272-282. doi: 10.1038/s41591-021-01645-7. Epub 2022 Feb 3. Nat Med. 2022. PMID: 35115708
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Song KW, Edgar KA, Hanan EJ, Hafner M, Oeh J, Merchant M, Sampath D, Nannini MA, Hong R, Phu L, Forrest WF, Stawiski E, Schmidt S, Endres N, Guan J, Wallin JJ, Cheong J, Plise EG, Lewis Phillips GD, Salphati L, Heffron TP, Olivero AG, Malek S, Staben ST, Kirkpatrick DS, Dey A, Friedman LS. Song KW, et al. Among authors: guan j. Cancer Discov. 2022 Jan;12(1):204-219. doi: 10.1158/2159-8290.CD-21-0072. Epub 2021 Sep 20. Cancer Discov. 2022. PMID: 34544753
COMMD10 inhibits HIF1α/CP loop to enhance ferroptosis and radiosensitivity by disrupting Cu-Fe balance in hepatocellular carcinoma.
Yang M, Wu X, Hu J, Wang Y, Wang Y, Zhang L, Huang W, Wang X, Li N, Liao L, Chen M, Xiao N, Dai Y, Liang H, Huang W, Yuan L, Pan H, Li L, Chen L, Liu L, Liang L, Guan J. Yang M, et al. Among authors: guan j. J Hepatol. 2022 May;76(5):1138-1150. doi: 10.1016/j.jhep.2022.01.009. Epub 2022 Jan 29. J Hepatol. 2022. PMID: 35101526 Free article.
3,757 results