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An adapted consensus protein design strategy for identifying globally optimal biotherapeutics.
Liu Y, Tsang K, Mays M, Hansen G, Chiecko J, Crames M, Wei Y, Zhou W, Fredrick C, Hu J, Liu D, Gebhard D, Huang ZF, Datar A, Kronkaitis A, Gueneva-Boucheva K, Seeliger D, Han F, Sen S, Kasturirangan S, Scheer JM, Nixon AE, Panavas T, Marlow MS, Kumar S. Liu Y, et al. Among authors: gueneva boucheva k. MAbs. 2022 Jan-Dec;14(1):2073632. doi: 10.1080/19420862.2022.2073632. MAbs. 2022. PMID: 35613320 Free PMC article.
Piperazinyl-oxadiazoles as selective sphingosine-1-phosphate receptor agonists.
Horan JC, Sanyal S, Choi Y, Hill-Drzewi M, Patnaude L, Anderson S, Fogal S, Mao C, Cook BN, Gueneva-Boucheva K, Fisher MB, Hickey E, Pack E, Bannen LC, Chan DS, Mac MB, Ng SM, Wang Y, Xu W, Modis LK, Lemieux RM. Horan JC, et al. Among authors: gueneva boucheva k. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4807-11. doi: 10.1016/j.bmcl.2014.09.003. Epub 2014 Sep 6. Bioorg Med Chem Lett. 2014. PMID: 25241927
A Soluble Guanylate Cyclase Activator Inhibits the Progression of Diabetic Nephropathy in the ZSF1 Rat.
Boustany-Kari CM, Harrison PC, Chen H, Lincoln KA, Qian HS, Clifford H, Wang H, Zhang X, Gueneva-Boucheva K, Bosanac T, Wong D, Fryer RM, Richman JG, Sarko C, Pullen SS. Boustany-Kari CM, et al. Among authors: gueneva boucheva k. J Pharmacol Exp Ther. 2016 Mar;356(3):712-9. doi: 10.1124/jpet.115.230706. Epub 2016 Jan 4. J Pharmacol Exp Ther. 2016. PMID: 26729306
The Aldosterone Synthase Inhibitor FAD286 is Suitable for Lowering Aldosterone Levels in ZDF Rats but not in db/db Mice.
Hofmann A, Brunssen C, Peitzsch M, Balyura M, Mittag J, Frenzel A, Jannasch A, Brown NF, Weldon SM, Gueneva-Boucheva KK, Eisenhofer G, Bornstein SR, Morawietz H. Hofmann A, et al. Among authors: gueneva boucheva kk. Horm Metab Res. 2017 Jun;49(6):466-471. doi: 10.1055/s-0043-101821. Epub 2017 Apr 20. Horm Metab Res. 2017. PMID: 28427090
The Novel, Clinical-Stage Soluble Guanylate Cyclase Activator BI 685509 Protects from Disease Progression in Models of Renal Injury and Disease.
Reinhart GA, Harrison PC, Lincoln K, Chen H, Sun P, Hill J, Qian HS, McHugh MC, Clifford H, Ng KJ, Wang H, Fowler D, Gueneva-Boucheva K, Brenneman JB, Bosanac T, Wong D, Fryer RM, Sarko C, Boustany-Kari CM, Pullen SS. Reinhart GA, et al. Among authors: gueneva boucheva k. J Pharmacol Exp Ther. 2023 Mar;384(3):382-392. doi: 10.1124/jpet.122.001423. Epub 2022 Dec 6. J Pharmacol Exp Ther. 2023. PMID: 36507845