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Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake.
Schindler AG, Messinger DI, Smith JS, Shankar H, Gustin RM, Schattauer SS, Lemos JC, Chavkin NW, Hagan CE, Neumaier JF, Chavkin C. Schindler AG, et al. Among authors: gustin rm. J Neurosci. 2012 Dec 5;32(49):17582-96. doi: 10.1523/JNEUROSCI.3220-12.2012. J Neurosci. 2012. PMID: 23223282 Free PMC article.
Loss of GluN2B-containing NMDA receptors in CA1 hippocampus and cortex impairs long-term depression, reduces dendritic spine density, and disrupts learning.
Brigman JL, Wright T, Talani G, Prasad-Mulcare S, Jinde S, Seabold GK, Mathur P, Davis MI, Bock R, Gustin RM, Colbran RJ, Alvarez VA, Nakazawa K, Delpire E, Lovinger DM, Holmes A. Brigman JL, et al. Among authors: gustin rm. J Neurosci. 2010 Mar 31;30(13):4590-600. doi: 10.1523/JNEUROSCI.0640-10.2010. J Neurosci. 2010. PMID: 20357110 Free PMC article.