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Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.
Gamiz-Arco G, Gutierrez-Rus LI, Risso VA, Ibarra-Molero B, Hoshino Y, Petrović D, Justicia J, Cuerva JM, Romero-Rivera A, Seelig B, Gavira JA, Kamerlin SCL, Gaucher EA, Sanchez-Ruiz JM. Gamiz-Arco G, et al. Among authors: gutierrez rus li. Nat Commun. 2021 Jan 15;12(1):380. doi: 10.1038/s41467-020-20630-1. Nat Commun. 2021. PMID: 33452262 Free PMC article.
Cell Survival Enabled by Leakage of a Labile Metabolic Intermediate.
Medina-Carmona E, Gutierrez-Rus LI, Manssour-Triedo F, Newton MS, Gamiz-Arco G, Mota AJ, Reiné P, Cuerva JM, Ortega-Muñoz M, Andrés-León E, Ortega-Roldan JL, Seelig B, Ibarra-Molero B, Sanchez-Ruiz JM. Medina-Carmona E, et al. Among authors: gutierrez rus li. Mol Biol Evol. 2023 Mar 4;40(3):msad032. doi: 10.1093/molbev/msad032. Mol Biol Evol. 2023. PMID: 36788592 Free PMC article.