Salirasib Inhibits the Expression of Genes Involved in Fibrosis in Fibroblasts of Systemic Sclerosis Patients.
Sadeghi Shaker M, Rokni M, Kavosi H, Enayati S, Madreseh E, Mahmoudi M, Farhadi E, Vodjgani M.
Sadeghi Shaker M, et al.
Immun Inflamm Dis. 2024 Nov;12(11):e70063. doi: 10.1002/iid3.70063.
Immun Inflamm Dis. 2024.
PMID: 39601641
Free PMC article.
MATERIALS AND METHODS: Dermal fibroblasts from 10 SSc patients were treated with salirasib in the presence of TGF-beta1, and mRNA levels of H-Ras and genes related to fibrosis, such as COL1A1, COL1A2, CTGF, TGF-beta1, fibronectin, ACTA2, and MMP1 was measured by real-time …
MATERIALS AND METHODS: Dermal fibroblasts from 10 SSc patients were treated with salirasib in the presence of TGF-beta1, and mRNA levels of …