Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.
Tomic T, Botton T, Cerezo M, Robert G, Luciano F, Puissant A, Gounon P, Allegra M, Bertolotto C, Bereder JM, Tartare-Deckert S, Bahadoran P, Auberger P, Ballotti R, Rocchi S.
Tomic T, et al.
Cell Death Dis. 2011 Sep 1;2(9):e199. doi: 10.1038/cddis.2011.86.
Cell Death Dis. 2011.
PMID: 21881601
Free PMC article.
To better understand the basis of this antiproliferative effect of metformin in melanoma, we characterized the sequence of events underlying metformin action. We showed that 24 h metformin treatment induced a cell cycle arrest in G0/G1 phases, while after 72 h, mela …
To better understand the basis of this antiproliferative effect of metformin in melanoma, we characterized the sequence of events underlying …