Neuronal Glutamatergic Synaptic Clefts Alkalinize Rather Than Acidify during Neurotransmission.
Stawarski M, Hernandez RX, Feghhi T, Borycz JA, Lu Z, Agarwal AB, Reihl KD, Tavora R, Lau AWC, Meinertzhagen IA, Renden R, Macleod GT.
Stawarski M, et al.
J Neurosci. 2020 Feb 19;40(8):1611-1624. doi: 10.1523/JNEUROSCI.1774-19.2020. Epub 2020 Jan 21.
J Neurosci. 2020.
PMID: 31964719
Free PMC article.
Cleft pH transients were dependent on Ca(2+) movement across the postsynaptic membrane, rather than neurotransmitter release per se, a result consistent with cleft alkalinization being driven by the Ca(2+)/H(+) antiporting activity of the plasma membrane Ca(2+)-ATPase at t …
Cleft pH transients were dependent on Ca(2+) movement across the postsynaptic membrane, rather than neurotransmitter release per se, a resul …