Evaluation and selection of a lead diabody for interferon-γ PET imaging.
Rezazadeh F, Ramos N, Saliganan AD, Barr S, Peraino N, Schomburg F, Rancour D, Viola NT.
Rezazadeh F, et al.
Nucl Med Biol. 2022 Nov-Dec;114-115:162-167. doi: 10.1016/j.nucmedbio.2022.06.001. Epub 2022 Jun 17.
Nucl Med Biol. 2022.
PMID: 35753939
Free PMC article.
All tracers except for [(89)Zr]Zr-DFO-NCS-anti-IFN-gamma HL-9 exhibited comparable immunoreactivities (>90 %) to the radiolabeled parent mAb (95.8 %). At 24 h post-labeling, the IRF values were retained except for the HL-13 construct. Imaging scans and tissue distributi …
All tracers except for [(89)Zr]Zr-DFO-NCS-anti-IFN-gamma HL-9 exhibited comparable immunoreactivities (>90 %) to the radiolabeled parent …