Allosteric Inhibition of a Mammalian Lectin.
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C.
Aretz J, et al.
J Am Chem Soc. 2018 Nov 7;140(44):14915-14925. doi: 10.1021/jacs.8b08644. Epub 2018 Oct 24.
J Am Chem Soc. 2018.
PMID: 30303367
To overcome the supposedly poor druggability of C-type lectin receptors and to identify starting points for chemical probe development, we screened murine langerin using (1)H and (19)F NMR against a library of 871 drug-like fragments. Subsequently, hits were validated by s …
To overcome the supposedly poor druggability of C-type lectin receptors and to identify starting points for chemical probe development, we s …