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Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition.
Chen W, Zhang Y, Wang Z, Tan M, Lin J, Qian X, Li H, Jiang T. Chen W, et al. Front Pharmacol. 2023 Feb 20;14:1078205. doi: 10.3389/fphar.2023.1078205. eCollection 2023. Front Pharmacol. 2023. PMID: 36891270 Free PMC article.
Here, we investigated the effect and potential mechanism of DAPA against myocardial ischemia/reperfusion injury (MIRI)-related ferroptosis using the MIRI rat model and hypoxia/reoxygenation (H/R)-induced H9C2 cardiomyocytes. Our results show that DAPA …
Here, we investigated the effect and potential mechanism of DAPA against myocardial ischemia/reperfusion injury (MIRI)-related ferrop …
Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis.
Xu S, Wu B, Zhong B, Lin L, Ding Y, Jin X, Huang Z, Lin M, Wu H, Xu D. Xu S, et al. Bioengineered. 2021 Dec;12(2):10924-10934. doi: 10.1080/21655979.2021.1995994. Bioengineered. 2021. PMID: 34699317 Free PMC article.
But the regulatory effect and mechanism of NAR on ferroptosis in MIRI have not been reported. After the rats were given NAR and induced to form myocardial ischemia-reperfusion (MI/R) injury, Tetrazolium chloride (TTC) staining was used to detect the myocardial infar …
But the regulatory effect and mechanism of NAR on ferroptosis in MIRI have not been reported. After the rats were given NAR and induc …
Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K/Akt/mTOR Signaling Pathway and Reduces Myocardial Ischemia/Reperfusion Injury.
Qin GW, Lu P, Peng L, Jiang W. Qin GW, et al. Am J Chin Med. 2021;49(8):1913-1927. doi: 10.1142/S0192415X21500907. Epub 2021 Nov 13. Am J Chin Med. 2021. PMID: 34775933
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage in acute myocardial infarction, and its treatment remains a clinical challenge. ...Ginsenoside Rb1 abolished the MIRI-induced activation of autophagy. Meanwhile, we found that …
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage in acute myocardial infarction, and its tr …
Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.
Zhang CX, Cheng Y, Liu DZ, Liu M, Cui H, Zhang BL, Mei QB, Zhou SY. Zhang CX, et al. J Nanobiotechnology. 2019 Jan 25;17(1):18. doi: 10.1186/s12951-019-0451-9. J Nanobiotechnology. 2019. PMID: 30683110 Free PMC article.
The in vitro results showed that the intracellular uptake of CsA@PLGA-PEG-SS31 was significantly enhanced in hypoxia reoxygenation (H/R) injured H9c2 cells. CsA@PLGA-PEG-SS31 delivered CsA into mitochondria of H/R injured H9c2 cells and subsequently in …
The in vitro results showed that the intracellular uptake of CsA@PLGA-PEG-SS31 was significantly enhanced in hypoxia reoxygenation (H
Geniposide suppresses NLRP3 inflammasome-mediated pyroptosis via the AMPK signaling pathway to mitigate myocardial ischemia/reperfusion injury.
Li H, Yang DH, Zhang Y, Zheng F, Gao F, Sun J, Shi G. Li H, et al. Chin Med. 2022 Jun 17;17(1):73. doi: 10.1186/s13020-022-00616-5. Chin Med. 2022. PMID: 35715805 Free PMC article.
However, research on the specific mechanism of geniposide has not been reported. METHODS: The MIRI model of animal was created in male C57BL/6J mice and the hypoxia reoxygenation (H/R) model was established for the in vitro experiments. ...AMPK antagonist or …
However, research on the specific mechanism of geniposide has not been reported. METHODS: The MIRI model of animal was created in mal …
Baicalin regulates macrophages polarization and alleviates myocardial ischaemia/reperfusion injury via inhibiting JAK/STAT pathway.
Xu M, Li X, Song L. Xu M, et al. Pharm Biol. 2020 Dec;58(1):655-663. doi: 10.1080/13880209.2020.1779318. Pharm Biol. 2020. PMID: 32649845 Free PMC article.
We hypothesized that baicalin-modulated macrophages change from M1 (pro-inflammatory subset) to M2 (anti-inflammatory subset) under I/R stress. MATERIALS AND METHODS: We established an ischaemia/reperfusion (I/R) model using Sprague Dawley (SD) rat, then baicalin wa …
We hypothesized that baicalin-modulated macrophages change from M1 (pro-inflammatory subset) to M2 (anti-inflammatory subset) under I/R
Pretreatment with Panaxatriol Saponin Attenuates Mitochondrial Apoptosis and Oxidative Stress to Facilitate Treatment of Myocardial Ischemia-Reperfusion Injury via the Regulation of Keap1/Nrf2 Activity.
Yao H, Xie Q, He Q, Zeng L, Long J, Gong Y, Li X, Li X, Liu W, Xu Z, Wu H, Zheng C, Gao Y. Yao H, et al. Oxid Med Cell Longev. 2022 May 27;2022:9626703. doi: 10.1155/2022/9626703. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35669855 Free PMC article.
This study was performed to investigate the protective effect of PTS against MIRI and explore the potential underlying mechanisms. Hydrogen peroxide (H(2)O(2)) was used to stimulate cardiomyocytes, to mimic MIRI in vitro. ...These results suggested that PTS h …
This study was performed to investigate the protective effect of PTS against MIRI and explore the potential underlying mechanisms. Hy …
YQHX Alleviates H/R-Induced Cardiomyocyte Apoptosis by Downregulating miR-1.
Ge L, Fan Y, Fu L, Guo M, Cao P, Peng C, Wu L, Han L, Wu H. Ge L, et al. Evid Based Complement Alternat Med. 2021 Nov 2;2021:4852406. doi: 10.1155/2021/4852406. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34765002 Free PMC article.
Yiqi Huoxue granule (YQHX) inhibits cardiomyocyte apoptosis in myocardial ischemia-reperfusion injury (MIRI); however, the underlying mechanism is unknown. In this study, hypoxia-reoxygenation (H/R) models were established using rat myocardial primary cells a …
Yiqi Huoxue granule (YQHX) inhibits cardiomyocyte apoptosis in myocardial ischemia-reperfusion injury (MIRI); however, the underlying …
CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.
Yang YN, Luo YB, Xu G, Li K, Ma RL, Yuan W. Yang YN, et al. Kaohsiung J Med Sci. 2023 Jul;39(7):675-687. doi: 10.1002/kjm2.12686. Epub 2023 Apr 25. Kaohsiung J Med Sci. 2023. PMID: 37096660 Free article.
Dual-luciferase assay was used to confirm these interaction sequences. CircHECTD1 and ROCK2 were upregulated in the rat MIRI model, while miR-138-5p was decreased. CircHECTD1 knockdown alleviated H/R-induced inflammation in H9c2 cells. ...Our research suggest …
Dual-luciferase assay was used to confirm these interaction sequences. CircHECTD1 and ROCK2 were upregulated in the rat MIRI model, w …
Ozone pretreatment alleviates ischemiareperfusion injury-induced myocardial ferroptosis by activating the Nrf2/Slc7a11/Gpx4 axis.
Ding S, Duanmu X, Xu L, Zhu L, Wu Z. Ding S, et al. Biomed Pharmacother. 2023 Sep;165:115185. doi: 10.1016/j.biopha.2023.115185. Epub 2023 Jul 22. Biomed Pharmacother. 2023. PMID: 37487441 Free article.
To establish an in vivo animal model of ischemiareperfusion injury (I/R), this study utilized C57 mice, while an in vitro model of hypoxia-reoxygenation (H/R) injury was developed using H9c2 cardiomyocytes to simulate ischemiareperfusion injury. ...Significan …
To establish an in vivo animal model of ischemiareperfusion injury (I/R), this study utilized C57 mice, while an in vitro model of hy …
212 results