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104 results

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Page 1
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.
Abedini A, Levinsohn J, Klötzer KA, Dumoulin B, Ma Z, Frederick J, Dhillon P, Balzer MS, Shrestha R, Liu H, Vitale S, Bergeson AM, Devalaraja-Narashimha K, Grandi P, Bhattacharyya T, Hu E, Pullen SS, Boustany-Kari CM, Guarnieri P, Karihaloo A, Traum D, Yan H, Coleman K, Palmer M, Sarov-Blat L, Morton L, Hunter CA, Kaestner KH, Li M, Susztak K. Abedini A, et al. Nat Genet. 2024 Aug;56(8):1712-1724. doi: 10.1038/s41588-024-01802-x. Epub 2024 Jul 24. Nat Genet. 2024. PMID: 39048792 Free PMC article.
Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis.
Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K. Doke T, et al. Nat Immunol. 2022 Jun;23(6):947-959. doi: 10.1038/s41590-022-01200-7. Epub 2022 May 12. Nat Immunol. 2022. PMID: 35552540 Free PMC article.
In mice, these basophils are an important source of interleukin-6 and recruitment of the T(H)17 subset of helper T cells. Genetic deletion or antibody-based depletion of basophils results in reduced renal fibrosis. ...
In mice, these basophils are an important source of interleukin-6 and recruitment of the T(H)17 subset of helper T cells. Genetic del …
Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.
Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R, S Balzer M, Park J, Zhou T, Ma Z, Sullivan KM, Hu H, Sheng X, Liu H, Wei Y, Boustany-Kari CM, Patel U, Almaani S, Palmer M, Townsend R, Blady S, Hogan J, Morton L, Susztak K; TRIDENT Study Investigators. Abedini A, et al. J Am Soc Nephrol. 2021 Mar;32(3):614-627. doi: 10.1681/ASN.2020050757. Epub 2021 Feb 2. J Am Soc Nephrol. 2021. PMID: 33531352 Free PMC article.
Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants.
Liu H, Abedini A, Ha E, Ma Z, Sheng X, Dumoulin B, Qiu C, Aranyi T, Li S, Dittrich N, Chen HC, Tao R, Tarng DC, Hsieh FJ, Chen SA, Yang SF, Lee MY, Kwok PY, Wu JY, Chen CH, Khan A, Limdi NA, Wei WQ, Walunas TL, Karlson EW, Kenny EE, Luo Y, Kottyan L, Connolly JJ, Jarvik GP, Weng C, Shang N, Cole JB, Mercader JM, Mandla R, Majarian TD, Florez JC, Haas ME, Lotta LA; Regeneron Genetics Center‡; GHS-RGC DiscovEHR Collaboration§; Drivas TG; Penn Medicine BioBank¶; Vy HMT, Nadkarni GN, Wiley LK, Wilson MP, Gignoux CR, Rasheed H, Thomas LF, Åsvold BO, Brumpton BM, Hallan SI, Hveem K, Zheng J, Hellwege JN, Zawistowski M, Zöllner S, Franceschini N, Hu H, Zhou J, Kiryluk K, Ritchie MD, Palmer M, Edwards TL, Voight BF, Hung AM, Susztak K; Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration; Penn Medicine BioBank. Liu H, et al. Science. 2025 Feb 7;387(6734):eadp4753. doi: 10.1126/science.adp4753. Epub 2025 Feb 7. Science. 2025. PMID: 39913582
Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker.
Hirohama D, Abedini A, Moon S, Surapaneni A, Dillon ST, Vassalotti A, Liu H, Doke T, Martinez V, Md Dom Z, Karihaloo A, Palmer MB, Coresh J, Grams ME, Niewczas MA, Susztak K. Hirohama D, et al. J Am Soc Nephrol. 2023 Jul 1;34(7):1279-1291. doi: 10.1681/ASN.0000000000000141. Epub 2023 Apr 5. J Am Soc Nephrol. 2023. PMID: 37022120 Free PMC article.
Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial.
Curtis JR, Lee RY, Brumback LC, Kross EK, Downey L, Torrence J, LeDuc N, Mallon Andrews K, Im J, Heywood J, Brown CE, Sibley J, Lober WB, Cohen T, Weiner BJ, Khandelwal N, Abedini NC, Engelberg RA. Curtis JR, et al. JAMA. 2023 Jun 20;329(23):2028-2037. doi: 10.1001/jama.2023.8812. JAMA. 2023. PMID: 37210665 Free PMC article.
Neuropalliative Care for Stroke Providers.
Creutzfeldt CJ, Abedini NC, Holloway RG. Creutzfeldt CJ, et al. Stroke. 2023 Nov;54(11):e485-e487. doi: 10.1161/STROKEAHA.123.040431. Epub 2023 Oct 10. Stroke. 2023. PMID: 37814954 No abstract available.
104 results