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Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/beta-catenin signaling via its FadA adhesin.
Rubinstein MR, Wang X, Liu W, Hao Y, Cai G, Han YW. Rubinstein MR, et al. Cell Host Microbe. 2013 Aug 14;14(2):195-206. doi: 10.1016/j.chom.2013.07.012. Cell Host Microbe. 2013. PMID: 23954158 Free PMC article.
The FadA-binding site on E-cadherin is mapped to an 11-amino-acid region. A synthetic peptide derived from this region of E-cadherin abolishes FadA-induced CRC cell growth and oncogenic and inflammatory responses. ...The increased FadA expression in CRC corre …
The FadA-binding site on E-cadherin is mapped to an 11-amino-acid region. A synthetic peptide derived from this region of E-cadherin …
Fusobacterium nucleatum: a commensal-turned pathogen.
Han YW. Han YW. Curr Opin Microbiol. 2015 Feb;23:141-7. doi: 10.1016/j.mib.2014.11.013. Epub 2015 Jan 8. Curr Opin Microbiol. 2015. PMID: 25576662 Free PMC article. Review.
The virulence mechanisms involved in the diseases are discussed, with emphasis on its colonization, systemic dissemination, and induction of host inflammatory and tumorigenic responses. The FadA adhesin/invasin conserved in F. nucleatum is a key virulence factor and a pote …
The virulence mechanisms involved in the diseases are discussed, with emphasis on its colonization, systemic dissemination, and induction of …
Fusobacterium nucleatum secretes amyloid-like FadA to enhance pathogenicity.
Meng Q, Gao Q, Mehrazarin S, Tangwanichgapong K, Wang Y, Huang Y, Pan Y, Robinson S, Liu Z, Zangiabadi A, Lux R, Papapanou PN, Guo XE, Wang H, Berchowitz LE, Han YW. Meng Q, et al. EMBO Rep. 2021 Jul 5;22(7):e52891. doi: 10.15252/embr.202152891. Epub 2021 Jun 29. EMBO Rep. 2021. PMID: 34184813 Free PMC article.
The extracellular FadA binds Congo Red, Thioflavin-T, and antibodies raised against human amyloid beta42. ...The uncleaved signal peptide of FadA is required for the formation and stability of mature amyloid FadA fibrils. We propose a model in which hydrophob …
The extracellular FadA binds Congo Red, Thioflavin-T, and antibodies raised against human amyloid beta42. ...The uncleaved signal pep …
Fusobacterium nucleatum promotes colorectal cancer by inducing Wnt/β-catenin modulator Annexin A1.
Rubinstein MR, Baik JE, Lagana SM, Han RP, Raab WJ, Sahoo D, Dalerba P, Wang TC, Han YW. Rubinstein MR, et al. EMBO Rep. 2019 Apr;20(4):e47638. doi: 10.15252/embr.201847638. Epub 2019 Mar 4. EMBO Rep. 2019. PMID: 30833345 Free PMC article.
Its expression level in colon cancer is a predictor of poor prognosis independent of cancer stage, grade, age, and sex. The FadA adhesin from F. nucleatum up-regulates Annexin A1 expression through E-cadherin. A positive feedback loop between FadA and Annexin A1 is …
Its expression level in colon cancer is a predictor of poor prognosis independent of cancer stage, grade, age, and sex. The FadA adhe …
Banxia Xiexin Decoction delays colitis-to-cancer transition by inhibiting E-cadherin/beta-catenin pathway via Fusobacterium nucleatum FadA.
Jiang Y, Huang Y, Hu Y, Yang Y, You F, Hu Q, Li X, Zhao Z. Jiang Y, et al. J Ethnopharmacol. 2024 Jun 28;328:117932. doi: 10.1016/j.jep.2024.117932. Epub 2024 Feb 20. J Ethnopharmacol. 2024. PMID: 38382652
The growth status of colon tumors was observed by hematoxylin and eosin (H&E) staining, and the changes in gut microbiota in each group of mice were detected by 16S rDNA analysis. ...More importantly, we found that BXD-containing serum can inhibit the binding of Fn's …
The growth status of colon tumors was observed by hematoxylin and eosin (H&E) staining, and the changes in gut microbiota in each …
FadA from Fusobacterium nucleatum utilizes both secreted and nonsecreted forms for functional oligomerization for attachment and invasion of host cells.
Xu M, Yamada M, Li M, Liu H, Chen SG, Han YW. Xu M, et al. J Biol Chem. 2007 Aug 24;282(34):25000-9. doi: 10.1074/jbc.M611567200. Epub 2007 Jun 22. J Biol Chem. 2007. PMID: 17588948 Free article.
In both E. coli and F. nucleatum, FadA exists in two forms, the intact pre-FadA and the secreted mature FadA (mFadA), with pre-FadA anchored in the inner membrane and mFadA secreted outside the bacteria. Pre-FadA and mFadA formed high M(r) compl …
In both E. coli and F. nucleatum, FadA exists in two forms, the intact pre-FadA and the secreted mature FadA (mFadA), w …
Circulating IgA Antibodies Against Fusobacterium nucleatum Amyloid Adhesin FadA are a Potential Biomarker for Colorectal Neoplasia.
Baik JE, Li L, Shah MA, Freedberg DE, Jin Z, Wang TC, Han YW. Baik JE, et al. Cancer Res Commun. 2022 Nov 29;2(11):1497-1503. doi: 10.1158/2767-9764.CRC-22-0248. eCollection 2022 Nov. Cancer Res Commun. 2022. PMID: 36970057 Free PMC article.
Fn encodes a unique amyloid-like adhesin, FadA complex (FadAc), consisting of intact pre-FadA and cleaved mature FadA, to promote colorectal cancer tumorigenesis. ...
Fn encodes a unique amyloid-like adhesin, FadA complex (FadAc), consisting of intact pre-FadA and cleaved mature FadA, …
Study of the inflammatory activating process in the early stage of Fusobacterium nucleatum infected PDLSCs.
Wang Y, Wang L, Sun T, Shen S, Li Z, Ma X, Gu X, Zhang X, Peng A, Xu X, Feng Q. Wang Y, et al. Int J Oral Sci. 2023 Feb 8;15(1):8. doi: 10.1038/s41368-022-00213-0. Int J Oral Sci. 2023. PMID: 36754953 Free PMC article.
Further study showed that FadA could bind with PEBP1 to activate the Raf1-MAPK and IKK-NF-kappaB signaling pathways. ...NFkappaB1 and NFkappaB2 upregulated after 3 h of F. nucleatum-infection, and the inflammatory-related genes in the NF-kappaB signaling pathway wer …
Further study showed that FadA could bind with PEBP1 to activate the Raf1-MAPK and IKK-NF-kappaB signaling pathways. ...NFkappaB1 and …
Complementation of the fadA mutation in Fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization.
Ikegami A, Chung P, Han YW. Ikegami A, et al. Infect Immun. 2009 Jul;77(7):3075-9. doi: 10.1128/IAI.00209-09. Epub 2009 Apr 27. Infect Immun. 2009. PMID: 19398541 Free PMC article.
In this study, a fadA-complementing clone, F. nucleatum 12230 USF81, was constructed. The expression of FadA on USF81 was confirmed by Western blotting and immunofluorescent labeling. ...FadA may be a therapeutic target for preventing F. nucleatum colonizatio …
In this study, a fadA-complementing clone, F. nucleatum 12230 USF81, was constructed. The expression of FadA on USF81 was conf …
Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity.
Fardini Y, Wang X, Témoin S, Nithianantham S, Lee D, Shoham M, Han YW. Fardini Y, et al. Mol Microbiol. 2011 Dec;82(6):1468-80. doi: 10.1111/j.1365-2958.2011.07905.x. Epub 2011 Nov 15. Mol Microbiol. 2011. PMID: 22040113 Free PMC article.
We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In this study, vascular endothelial (VE)-cadherin, a member of the cadherin family and a cell-cell junction molecule, was identified as the end …
We have shown previously that F. nucleatum adheres to and invades host epithelial and endothelial cells via a novel FadA adhesin. In …
67 results