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1991 2
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558 results

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Page 1
Dapagliflozin alleviates myocardial ischemia/reperfusion injury by reducing ferroptosis via MAPK signaling inhibition.
Chen W, Zhang Y, Wang Z, Tan M, Lin J, Qian X, Li H, Jiang T. Chen W, et al. Front Pharmacol. 2023 Feb 20;14:1078205. doi: 10.3389/fphar.2023.1078205. eCollection 2023. Front Pharmacol. 2023. PMID: 36891270 Free PMC article.
Here, we investigated the effect and potential mechanism of DAPA against myocardial ischemia/reperfusion injury (MIRI)-related ferroptosis using the MIRI rat model and hypoxia/reoxygenation (H/R)-induced H9C2 cardiomyocytes. ...Subsequently, network pharmacol …
Here, we investigated the effect and potential mechanism of DAPA against myocardial ischemia/reperfusion injury (MIRI)-related ferrop …
Ginsenoside Rb1 Inhibits Cardiomyocyte Autophagy via PI3K/Akt/mTOR Signaling Pathway and Reduces Myocardial Ischemia/Reperfusion Injury.
Qin GW, Lu P, Peng L, Jiang W. Qin GW, et al. Am J Chin Med. 2021;49(8):1913-1927. doi: 10.1142/S0192415X21500907. Epub 2021 Nov 13. Am J Chin Med. 2021. PMID: 34775933
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage in acute myocardial infarction, and its treatment remains a clinical challenge. ...Ginsenoside Rb1 abolished the MIRI-induced activation of autophagy. Meanwhile, we found that …
Myocardial ischemia/reperfusion injury (MIRI) is the major cause of myocardial cell damage in acute myocardial infarction, and its tr …
Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2) /System xc-/ glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis.
Xu S, Wu B, Zhong B, Lin L, Ding Y, Jin X, Huang Z, Lin M, Wu H, Xu D. Xu S, et al. Bioengineered. 2021 Dec;12(2):10924-10934. doi: 10.1080/21655979.2021.1995994. Bioengineered. 2021. PMID: 34699317 Free PMC article.
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a flavonoid, has a significant advantage in improving MIRI. ...At the cellular level, ferroptosis inducer Erastin reversed the protective …
Ferroptosis is an important form of myocardial cell death in myocardial ischemia-reperfusion injury (MIRI). Naringenin (NAR), as a fl …
Suxiao Jiuxin Pill alleviates myocardial ischemia/reperfusion-induced autophagy via miR-193a-3p/ALKBH5 pathway.
Wang D, Wang D, Jin Q, Wang X. Wang D, et al. Phytomedicine. 2024 Mar;125:155359. doi: 10.1016/j.phymed.2024.155359. Epub 2024 Jan 24. Phytomedicine. 2024. PMID: 38301300 Free article.
RESULTS: SJP alleviated autophagy, preserved cardiac function, and minimized myocardial damage in the hearts of MIRI rats. SJP attenuated autophagy in H/R H9C2 cells. Elevated levels of miR-193a-3p were observed in the cardiac tissues of MIRI rats and H …
RESULTS: SJP alleviated autophagy, preserved cardiac function, and minimized myocardial damage in the hearts of MIRI rats. SJP attenu …
Galangin Attenuates Myocardial Ischemic Reperfusion-Induced Ferroptosis by Targeting Nrf2/Gpx4 Signaling Pathway.
Yang T, Liu H, Yang C, Mo H, Wang X, Song X, Jiang L, Deng P, Chen R, Wu P, Chen A, Yan J. Yang T, et al. Drug Des Devel Ther. 2023 Aug 22;17:2495-2511. doi: 10.2147/DDDT.S409232. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37637264 Free PMC article.
PURPOSE: Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally. The molecular mechanisms of MIRI need to be fully explored to develop new therapeutic methods. Galangin (Gal), which is a natural flavonoid extracted from Alpinia Officina …
PURPOSE: Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally. The molecular mechanisms of MIRI …
Single-cell profile reveals the landscape of cardiac immunity and identifies a cardio-protective Ym-1hi neutrophil in myocardial ischemia-reperfusion injury.
Dong Y, Kang Z, Zhang Z, Zhang Y, Zhou H, Liu Y, Shuai X, Li J, Yin L, Wang X, Ma Y, Fan H, Jiang F, Lin Z, Ding C, Yun Jin K, Sarapultsev A, Li F, Zhang G, Xie T, Yin C, Cheng X, Luo S, Liu Y, Hu D. Dong Y, et al. Sci Bull (Beijing). 2024 Apr 15;69(7):949-967. doi: 10.1016/j.scib.2024.02.003. Epub 2024 Feb 7. Sci Bull (Beijing). 2024. PMID: 38395651 Free article.
Myocardial ischemia-reperfusion injury (MIRI) is a major hindrance to the success of cardiac reperfusion therapy. Although increased neutrophil infiltration is a hallmark of MIRI, the subtypes and alterations of neutrophils in this process remain unclear. Here, we p …
Myocardial ischemia-reperfusion injury (MIRI) is a major hindrance to the success of cardiac reperfusion therapy. Although increased …
Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis.
Wang L, Liu J, Wang Z, Qian X, Zhao Y, Wang Q, Dai N, Xie Y, Zeng W, Yang W, Bai X, Yang Y, Qian J. Wang L, et al. Biomed Pharmacother. 2023 Sep;165:115255. doi: 10.1016/j.biopha.2023.115255. Epub 2023 Aug 5. Biomed Pharmacother. 2023. PMID: 37549462 Free article.
Hemodynamic parameters, infarction sizes, and histopathological changes were assessed to understand the effects of Dex on MIRI. We explored the mechanisms through functional experiments on an H9c2 cell hypoxia/reoxygenation (H/R) model. ...Our findings indicated tha …
Hemodynamic parameters, infarction sizes, and histopathological changes were assessed to understand the effects of Dex on MIRI. We ex …
Bioprinters for organs-on-chips.
Miri AK, Mostafavi E, Khorsandi D, Hu SK, Malpica M, Khademhosseini A. Miri AK, et al. Biofabrication. 2019 Sep 20;11(4):042002. doi: 10.1088/1758-5090/ab2798. Biofabrication. 2019. PMID: 31170695 Free PMC article. Review.
Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway.
Tian L, Cao W, Yue R, Yuan Y, Guo X, Qin D, Xing J, Wang X. Tian L, et al. J Pharmacol Sci. 2019 Apr;139(4):352-360. doi: 10.1016/j.jphs.2019.02.008. Epub 2019 Mar 8. J Pharmacol Sci. 2019. PMID: 30910451 Free article.
Mitochondrial energy metabolism and oxidative stress play a crucial role in ameliorating myocardial ischemia/reperfusion injury (MIRI). Tilianin has been reported to have a significant protection for mitochondrion in MIRI. ...This study investigated whether Tilianin …
Mitochondrial energy metabolism and oxidative stress play a crucial role in ameliorating myocardial ischemia/reperfusion injury (MIRI …
Sleep is required to consolidate odor memory and remodel olfactory synapses.
Chandra R, Farah F, Muñoz-Lobato F, Bokka A, Benedetti KL, Brueggemann C, Saifuddin MFA, Miller JM, Li J, Chang E, Varshney A, Jimenez V, Baradwaj A, Nassif C, Alladin S, Andersen K, Garcia AJ, Bi V, Nordquist SK, Dunn RL, Garcia V, Tokalenko K, Soohoo E, Briseno F, Kaur S, Harris M, Guillen H, Byrd D, Fung B, Bykov AE, Odisho E, Tsujimoto B, Tran A, Duong A, Daigle KC, Paisner R, Zuazo CE, Lin C, Asundi A, Churgin MA, Fang-Yen C, Bremer M, Kato S, VanHoven MK, L'Étoile ND. Chandra R, et al. Cell. 2023 Jun 22;186(13):2911-2928.e20. doi: 10.1016/j.cell.2023.05.006. Epub 2023 Jun 2. Cell. 2023. PMID: 37269832 Free PMC article.
558 results