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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 4
1976 3
1977 3
1978 6
1979 4
1980 1
1981 6
1982 1
1983 8
1984 4
1985 5
1986 5
1987 2
1988 4
1989 2
1990 1
1991 1
1992 9
1993 7
1994 4
1995 6
1996 6
1997 5
1998 10
1999 8
2000 6
2001 19
2002 10
2003 5
2004 9
2005 17
2006 14
2007 20
2008 30
2009 29
2010 28
2011 31
2012 20
2013 18
2014 27
2015 24
2016 30
2017 14
2018 22
2019 24
2020 29
2021 37
2022 33
2023 46
2024 24

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611 results

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Page 1
Inherited disorders of bilirubin clearance.
Memon N, Weinberger BI, Hegyi T, Aleksunes LM. Memon N, et al. Pediatr Res. 2016 Mar;79(3):378-86. doi: 10.1038/pr.2015.247. Epub 2015 Nov 23. Pediatr Res. 2016. PMID: 26595536 Free PMC article. Review.
Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of glucuronic acid to bilirubin (e.g., Gilbert syndrome, Crigler-Najjar syndrome, Lucey-Driscoll syndrome, breast milk jaundice), (iii) …
Reduced hepatic bilirubin clearance can be due to defective (i) unconjugated bilirubin uptake and intrahepatic storage, (ii) conjugation of …
Glia and epilepsy: excitability and inflammation.
Devinsky O, Vezzani A, Najjar S, De Lanerolle NC, Rogawski MA. Devinsky O, et al. Trends Neurosci. 2013 Mar;36(3):174-84. doi: 10.1016/j.tins.2012.11.008. Epub 2013 Jan 5. Trends Neurosci. 2013. PMID: 23298414 Review.
Gene Therapy in Patients with the Crigler-Najjar Syndrome.
D'Antiga L, Beuers U, Ronzitti G, Brunetti-Pierri N, Baumann U, Di Giorgio A, Aronson S, Hubert A, Romano R, Junge N, Bosma P, Bortolussi G, Muro AF, Soumoudronga RF, Veron P, Collaud F, Knuchel-Legendre N, Labrune P, Mingozzi F. D'Antiga L, et al. N Engl J Med. 2023 Aug 17;389(7):620-631. doi: 10.1056/NEJMoa2214084. N Engl J Med. 2023. PMID: 37585628 Clinical Trial.
BACKGROUND: Patients with the Crigler-Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1), the absence of which leads to severe unconjugated hyperbilirubinemia that can cause irreversible neurologic injury and death. ...METHODS …
BACKGROUND: Patients with the Crigler-Najjar syndrome lack the enzyme uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A …
Gilbert's syndrome.
Watson KJ, Gollan JL. Watson KJ, et al. Baillieres Clin Gastroenterol. 1989 Apr;3(2):337-55. doi: 10.1016/0950-3528(89)90004-3. Baillieres Clin Gastroenterol. 1989. PMID: 2655758 Review.
The syndrome is almost certainly part of a spectrum which includes the Crigler-Najjar syndromes; molecular biology data suggests that there is an absence of one (or even more) GT isoenzymes in these disorders. ...
The syndrome is almost certainly part of a spectrum which includes the Crigler-Najjar syndromes; molecular biology data suggests that …
Insulin Clearance in Health and Disease.
Najjar SM, Caprio S, Gastaldelli A. Najjar SM, et al. Annu Rev Physiol. 2023 Feb 10;85:363-381. doi: 10.1146/annurev-physiol-031622-043133. Epub 2022 Oct 19. Annu Rev Physiol. 2023. PMID: 36260807 Free article. Review.
Hepatocyte transplantation.
Fox IJ, Chowdhury JR. Fox IJ, et al. Am J Transplant. 2004;4 Suppl 6:7-13. doi: 10.1111/j.1600-6135.2004.0340.x. Am J Transplant. 2004. PMID: 14871269 Free article. Review.
Unfortunately, unequivocal evidence of transplanted human hepatocyte function has been obtained in only one patient with Crigler-Najjar syndrome type I, and, even then, the amount of bilirubin-UGT enzyme activity derived from the transplanted cells was not sufficient to el …
Unfortunately, unequivocal evidence of transplanted human hepatocyte function has been obtained in only one patient with Crigler-Najjar …
611 results