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32 results

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Page 1
Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models.
Allesøe RL, Lundgaard AT, Hernández Medina R, Aguayo-Orozco A, Johansen J, Nissen JN, Brorsson C, Mazzoni G, Niu L, Biel JH, Leal Rodríguez C, Brasas V, Webel H, Benros ME, Pedersen AG, Chmura PJ, Jacobsen UP, Mari A, Koivula R, Mahajan A, Vinuela A, Tajes JF, Sharma S, Haid M, Hong MG, Musholt PB, De Masi F, Vogt J, Pedersen HK, Gudmundsdottir V, Jones A, Kennedy G, Bell J, Thomas EL, Frost G, Thomsen H, Hansen E, Hansen TH, Vestergaard H, Muilwijk M, Blom MT, 't Hart LM, Pattou F, Raverdy V, Brage S, Kokkola T, Heggie A, McEvoy D, Mourby M, Kaye J, Hattersley A, McDonald T, Ridderstråle M, Walker M, Forgie I, Giordano GN, Pavo I, Ruetten H, Pedersen O, Hansen T, Dermitzakis E, Franks PW, Schwenk JM, Adamski J, McCarthy MI, Pearson E, Banasik K, Rasmussen S, Brunak S; IMI DIRECT Consortium. Allesøe RL, et al. Nat Biotechnol. 2023 Mar;41(3):399-408. doi: 10.1038/s41587-022-01520-x. Epub 2023 Jan 2. Nat Biotechnol. 2023. PMID: 36593394 Free PMC article.
A reference map of potential determinants for the human serum metabolome.
Bar N, Korem T, Weissbrod O, Zeevi D, Rothschild D, Leviatan S, Kosower N, Lotan-Pompan M, Weinberger A, Le Roy CI, Menni C, Visconti A, Falchi M, Spector TD; IMI DIRECT consortium; Adamski J, Franks PW, Pedersen O, Segal E. Bar N, et al. Nature. 2020 Dec;588(7836):135-140. doi: 10.1038/s41586-020-2896-2. Epub 2020 Nov 11. Nature. 2020. PMID: 33177712 Clinical Trial.
catena-Poly[[[aqua-cadmium(II)]bis-(μ-4-hydroxy-pyridine-2,6-dicarboxyl-ato)[aqua-cadmium(II)]di-μ-aqua] tetra-hydrate].
Aghabozorg H, Ilaie N, Heidari M, Manteghi F, Pasdar H. Aghabozorg H, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Sep 30;64(Pt 10):m1351-2. doi: 10.1107/S1600536808030869. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21201080 Free PMC article.
The title polymeric compound, {[Cd(2)(C(7)H(3)NO(5))(2)(H(2)O)(4)].4H(2)O}(n) or {[Cd(2)(hypydc)(2)(H(2)O)(4)].4H(2)O}(n) (where hypydcH(2) is 4-hydroxy-pyridine-2,6-dicarboxylic acid), was synthesized by the reaction of cadmium(II) nitrate hexa-hydrate with …
The title polymeric compound, {[Cd(2)(C(7)H(3)NO(5))(2)(H(2)O)(4)].4H(2)O}(n) or {[Cd(2)(hypydc)(2)(H(2)O)(4)].4H(2)O}( …
Poly[tri-μ(2)-aqua-(μ(3)-pyridine-2,4-dicarboxyl-ato-κN,O:O:O)barium].
Pasdar H, Siabi S, Notash B, Aghabozorg H, Foroughifar N. Pasdar H, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):m848. doi: 10.1107/S1600536811020204. Epub 2011 Jun 4. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21836851 Free PMC article.
In the polymeric title compound, [Ba(C(7)H(3)NO(4))(H(2)O)(3)](n), the Ba(II) ion is ten-coordinated in an NO(9) environment by one N atom and three O atoms from three pyridine-2,4-dicarboxyl-ate (pydc) ligands and six water mol-ecules. ...
In the polymeric title compound, [Ba(C(7)H(3)NO(4))(H(2)O)(3)](n), the Ba(II) ion is ten-coordinated in an NO(9) environment b …
Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain assembly at the plasma membrane.
Pasdar M, Krzeminski KA, Nelson WJ. Pasdar M, et al. J Cell Biol. 1991 May;113(3):645-55. doi: 10.1083/jcb.113.3.645. J Cell Biol. 1991. PMID: 1707884 Free PMC article.
We showed previously that in MDCK epithelial cells major components of the cytoplasmic plaque (desmoplakin I and II; DPI/II) and membrane core domains (desmoglein I; DGI) initially enter a pool of proteins that is soluble in buffers containing Triton X-100, and then titrate into …
We showed previously that in MDCK epithelial cells major components of the cytoplasmic plaque (desmoplakin I and II; DPI/II) and membrane co …
Kinetics of desmosome assembly in Madin-Darby canine kidney epithelial cells: temporal and spatial regulation of desmoplakin organization and stabilization upon cell-cell contact. II. Morphological analysis.
Pasdar M, Nelson WJ. Pasdar M, et al. J Cell Biol. 1988 Mar;106(3):687-95. doi: 10.1083/jcb.106.3.687. J Cell Biol. 1988. PMID: 3279050 Free PMC article.
Upon cell-cell contact, there is a rapid increase in the capacity of the insoluble pool at the expense of the soluble pool; subsequently, the insoluble pool is stabilized, while proteins remaining in the soluble pool continue to be degraded rapidly (Pasdar, M., and W. J. N …
Upon cell-cell contact, there is a rapid increase in the capacity of the insoluble pool at the expense of the soluble pool; subsequently, th …
Selenium supplementation induces mitochondrial biogenesis in trophoblasts.
Khera A, Dong LF, Holland O, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV. Khera A, et al. Placenta. 2015 Aug;36(8):863-9. doi: 10.1016/j.placenta.2015.06.010. Epub 2015 Jun 23. Placenta. 2015. PMID: 26154583
The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-1alpha and NRF-1 was examined by western blotting. RESULTS: Mitochondrial respiration was significantly enhanced post selenium supplementation in cells and tissues. ...
The levels of the mitochondrial biogenesis markers selenoprotein H, PGC-1alpha and NRF-1 was examined by western blotting. RESULTS: M …
Poly[aqua-(dimethyl sulfoxide)(μ(4)-pyridine-2,5-dicarboxyl-ato)calcium(II)].
Pasdar H, Safari Z, Aghabozorg H, Notash B, Mirzaei M. Pasdar H, et al. Acta Crystallogr Sect E Struct Rep Online. 2011 Jan 15;67(Pt 2):m221. doi: 10.1107/S1600536810054334. Acta Crystallogr Sect E Struct Rep Online. 2011. PMID: 21522881 Free PMC article.
In the polymeric title compound, [Ca(C(7)H(3)NO(4))(H(2)O)(C(2)H(6)OS)](n), the Ca(II) ion is coordinated in a distorted penta-gonal-bipyramidal CdNO(6) geometry. ...
In the polymeric title compound, [Ca(C(7)H(3)NO(4))(H(2)O)(C(2)H(6)OS)](n), the Ca(II) ion is coordinated in a distorte …
Hexaaqua-magnesium(II) bis-(pyridinium-2,6-dicarboxyl-ate).
Pasdar H, Heidari S, Aghabozorg H, Notash B. Pasdar H, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 Nov 17;66(Pt 12):m1581. doi: 10.1107/S1600536810046696. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21589266 Free PMC article.
In the title compound, [Mg(H(2)O)(6)](C(7)H(4)NO(4))(2), a single six-coordinate Mg(2+) cation (site symmetry 2/m) is bonded to six water mol-ecules in a distorted octa-hedral geometry. ...
In the title compound, [Mg(H(2)O)(6)](C(7)H(4)NO(4))(2), a single six-coordinate Mg(2+) cation (site symmetry 2/m) is bonded t …
Regulation of desmosome assembly in epithelial cells: kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain.
Pasdar M, Nelson WJ. Pasdar M, et al. J Cell Biol. 1989 Jul;109(1):163-77. doi: 10.1083/jcb.109.1.163. J Cell Biol. 1989. PMID: 2501314 Free PMC article.
Previously, we reported the kinetics of assembly of two components of the cytoplasmic plaque domain, Desmoplakin I/II (Pasdar, M., and W. J. Nelson. 1988. J. Cell Biol. 106:677-685 and 106:687-699. We have now extended this analysis to include a major glycoprotein componen …
Previously, we reported the kinetics of assembly of two components of the cytoplasmic plaque domain, Desmoplakin I/II (Pasdar, M., an …
32 results