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Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression.
Ashayeripanah M, Vega-Ramos J, Fernandez-Ruiz D, Valikhani S, Lun ATL, White JT, Young LJ, Yaftiyan A, Zhan Y, Wakim L, Caminschi I, Lahoud MH, Lew AM, Shortman K, Smyth GK, Heath WR, Mintern JD, Roquilly A, Villadangos JA. Ashayeripanah M, et al. Cell Rep. 2024 Feb 27;43(2):113754. doi: 10.1016/j.celrep.2024.113754. Epub 2024 Feb 13. Cell Rep. 2024. PMID: 38354086 Free article.
A tailor-made, self-sufficient and recyclable monooxygenase catalyst based on coimmobilized cytochrome P450 BM3 and glucose dehydrogenase.
Valikhani D, Bolivar JM, Dennig A, Nidetzky B. Valikhani D, et al. Biotechnol Bioeng. 2018 Oct;115(10):2416-2425. doi: 10.1002/bit.26802. Epub 2018 Aug 29. Biotechnol Bioeng. 2018. PMID: 30036448 Free PMC article.
Cytochrome P450 monooxygenases (P450s) promote hydroxylations in a broad variety of substrates. Their prowess in C-H bond functionalization renders P450s promising catalysts for organic synthesis. However, operating P450 reactions involve complex management of the main sub …
Cytochrome P450 monooxygenases (P450s) promote hydroxylations in a broad variety of substrates. Their prowess in C-H bond functionali …
Altered expression of gamma-synuclein and detoxification-related genes in lungs of rats exposed to JP-8.
Espinoza LA, Valikhani M, Cossio MJ, Carr T, Jung M, Hyde J, Witten ML, Smulson ME. Espinoza LA, et al. Am J Respir Cell Mol Biol. 2005 Mar;32(3):192-200. doi: 10.1165/rcmb.2004-0171OC. Epub 2004 Dec 23. Am J Respir Cell Mol Biol. 2005. PMID: 15618438
We have now used microarray analysis to characterize changes in the gene expression profile of lung tissue induced by exposure of rats to JP-8 at a concentration of 171 or 352 mg/m(3) for 1 h/d for 7 d, with the higher dose estimated to mimic the level of occupational expo …
We have now used microarray analysis to characterize changes in the gene expression profile of lung tissue induced by exposure of rats to JP …
Role of thiopurine methyltransferase activity in the safety and efficacy of azathioprine in the treatment of pemphigus vulgaris.
Firooz A, Ghandi N, Hallaji Z, Chams-Davatchi C, Valikhani M, Karbakhsh Davari M. Firooz A, et al. Arch Dermatol. 2008 Sep;144(9):1143-7. doi: 10.1001/archderm.144.9.1143. Arch Dermatol. 2008. PMID: 18794458
RESULTS: The median activity of TPMT was 44.7 ng/mL/h (interquartile range, 28.7 ng/mL/h). Eleven patients (7.9%) had low TPMT activity (TPMT-HL), 127 patients (91.4%) had normal TPMT activity (TPMT-HH), and 1 patient (0.7%) had supranormal enzyme activity; TPMT act …
RESULTS: The median activity of TPMT was 44.7 ng/mL/h (interquartile range, 28.7 ng/mL/h). Eleven patients (7.9%) had low TPMT …