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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1982 2
1984 2
1989 1
1991 2
1992 1
1997 1
1998 1
2001 1
2002 1
2003 1
2004 1
2006 5
2007 7
2008 11
2009 8
2010 12
2011 18
2012 17
2013 33
2014 30
2015 26
2016 23
2017 20
2018 40
2019 22
2020 33
2021 34
2022 39
2023 32
2024 24
2025 32
2026 15

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415 results

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Page 1
Evidence-based clinical practice guidelines for inflammatory bowel disease 2020.
Nakase H, Uchino M, Shinzaki S, Matsuura M, Matsuoka K, Kobayashi T, Saruta M, Hirai F, Hata K, Hiraoka S, Esaki M, Sugimoto K, Fuji T, Watanabe K, Nakamura S, Inoue N, Itoh T, Naganuma M, Hisamatsu T, Watanabe M, Miwa H, Enomoto N, Shimosegawa T, Koike K. Nakase H, et al. Among authors: hirai f. J Gastroenterol. 2021 Jun;56(6):489-526. doi: 10.1007/s00535-021-01784-1. Epub 2021 Apr 22. J Gastroenterol. 2021. PMID: 33885977 Free PMC article. Review.
Inadequate Efficacy of Biologics for Treating Proximal Ileal Lesions in Crohn's Disease: A Prospective Multicenter Study.
Takenaka K, Hisamatsu T, Kobayashi T, Yamamoto H, Ohmiya N, Hayashi R, Matsuoka K, Saruta M, Andoh A, Fukata N, Watanabe K, Imaeda H, Hirai F, Matsumoto T, Hirakawa A, Yano T, Matsuura M, Okamoto R, Ohtsuka K, Watanabe M. Takenaka K, et al. Among authors: hirai f. Clin Gastroenterol Hepatol. 2025 Oct;23(11):1991-2000. doi: 10.1016/j.cgh.2024.10.030. Epub 2024 Dec 16. Clin Gastroenterol Hepatol. 2025. PMID: 39694212
Amiodarone-induced hepatotoxicity.
Nagata T, Takata K, Shakado S, Hirai F. Nagata T, et al. Among authors: hirai f. BMJ Case Rep. 2023 Nov 1;16(11):e256679. doi: 10.1136/bcr-2023-256679. BMJ Case Rep. 2023. PMID: 37914162 Free PMC article. No abstract available.
Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Crohn's Disease.
Sands BE, Peyrin-Biroulet L, Kierkus J, Higgins PDR, Fischer M, Jairath V, Hirai F, D'Haens G, Belin RM, Miller D, Gomez-Valderas E, Naegeli AN, Tuttle JL, Pollack PF, Sandborn WJ. Sands BE, et al. Among authors: hirai f. Gastroenterology. 2022 Feb;162(2):495-508. doi: 10.1053/j.gastro.2021.10.050. Epub 2021 Nov 5. Gastroenterology. 2022. PMID: 34748774 Free article. Clinical Trial.
AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.
Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T; AJM300 Study Group. Matsuoka K, et al. Among authors: hirai f. Lancet Gastroenterol Hepatol. 2022 Jul;7(7):648-657. doi: 10.1016/S2468-1253(22)00022-X. Epub 2022 Mar 30. Lancet Gastroenterol Hepatol. 2022. PMID: 35366419 Clinical Trial.
Guselkumab in East Asians With Moderate-to-Severe Ulcerative Colitis: Subgroup Analysis of the QUASAR Induction and Maintenance Studies.
Chen B, Ye BD, Cao Q, Hirai F, Saruta M, Chen M, Pelak S, Shipitofsky N, Miao Y, Herr K, Wahking B, Zhuo J, Hisamatsu T. Chen B, et al. Among authors: hirai f. J Gastroenterol Hepatol. 2025 Sep;40(9):2197-2208. doi: 10.1111/jgh.17036. Epub 2025 Jun 26. J Gastroenterol Hepatol. 2025. PMID: 40574492 Free PMC article. Clinical Trial.
Optimising carotegrast methyl use in ulcerative colitis: patient profiling, predictive biomarkers, and timing of efficacy evaluation (ASPECT study).
Matsuoka K, Hirai F, Watanabe K, Hokari R, Kobayashi T, Saruta M, Nakase H, Suzuki T, Yamazaki G, Hibi T, Watanabe M, Hisamatsu T. Matsuoka K, et al. Among authors: hirai f. J Gastroenterol. 2025 Dec;60(12):1523-1534. doi: 10.1007/s00535-025-02299-9. Epub 2025 Sep 22. J Gastroenterol. 2025. PMID: 40982097 Free PMC article. Clinical Trial.
Impact of COVID-19 on corneal esthesiometry.
Tochetto LB, de Freitas Santoro D, Hirai F, Conte DD, Höfling-Lima AL, Sousa LB, Bellei NCJ, De Freitas D, de Oliveira LA. Tochetto LB, et al. Among authors: hirai f. Br J Ophthalmol. 2022 Apr;106(4):458-460. doi: 10.1136/bjophthalmol-2021-320003. Epub 2021 Nov 10. Br J Ophthalmol. 2022. PMID: 34758962
Comparison Analysis of Lenvatinib Plus Transcatheter Arterial Chemoembolization Versus Atezolizumab Plus Bevacizumab as First-Line Therapy for Intermediate-Stage Hepatocellular Carcinoma Beyond the Up-to-Seven Criteria.
Niizeki T, Mawatari S, Shibata M, Sasaki R, Itoh S, Shakado S, Sugimoto R, Morita Y, Kuwashiro T, Endo M, Iwao M, Motoyoshi Y, Nakano M, Shimose S, Takahashi H, Yatsuhashi H, Hirai F, Yoshizumi T, Miyaaki H, Kawaguchi T, Ido A, Harada M. Niizeki T, et al. Among authors: hirai f. J Gastroenterol Hepatol. 2025 Aug;40(8):2060-2067. doi: 10.1111/jgh.17024. Epub 2025 May 31. J Gastroenterol Hepatol. 2025. PMID: 40448543
Anti-integrin αvβ6 antibody as a biomarker for diagnosing ulcerative colitis: a nationwide multicenter validation study.
Okabe M, Yamamoto S, Shiokawa M, Hisamatsu T, Yamazaki H, Nakanishi R, Hamada K, Kitamoto H, Kuwada T, Uza N, Sakatani A, Fujii T, Ohno M, Matsuura M, Shibuya T, Ohmiya N, Ooi M, Hoshi N, Moriya K, Tsuchiya K, Yamaguchi Y, Kunisaki R, Takahara M, Takagi T, Takehara T, Hirai F, Kakimoto K, Esaki M, Nakase H, Kinjo F, Torisu T, Kanmura S, Narimatsu K, Matsuoka K, Hiraga H, Yokoyama K, Honzawa Y, Naganuma M, Saruta M, Kodama Y, Chiba T, Seno H. Okabe M, et al. Among authors: hirai f. J Gastroenterol. 2025 Jan;60(1):86-95. doi: 10.1007/s00535-024-02176-x. Epub 2024 Nov 28. J Gastroenterol. 2025. PMID: 39607498 Free PMC article.
415 results