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Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations.
Kim KB, Desprez PY, de Semir D, Woo RWL, Sharma A, Jones R, Caressi C, Nosrati M, Janiczek E, Rivera Penafiel J, Kashani-Sabet M. Kim KB, et al. JCO Precis Oncol. 2025 May;9:e2400658. doi: 10.1200/PO-24-00658. Epub 2025 May 15. JCO Precis Oncol. 2025. PMID: 40373259 Clinical Trial.
Up to one third of melanomas harbor at least one molecular aberration in the homologous recombination (HR) pathway, leading to HR deficiency. PATIENTS AND METHODS: In this single-arm trial, we assessed the overall response rate to niraparib in patients with metastat …
Up to one third of melanomas harbor at least one molecular aberration in the homologous recombination (HR) pathway, leading to HR …
Prevalence of Homologous Recombination Pathway Gene Mutations in Melanoma: Rationale for a New Targeted Therapeutic Approach.
Kim KB, Soroceanu L, de Semir D, Millis SZ, Ross J, Vosoughi E, Dar AA, Nosrati M, Desprez PY, Ice R, Chen M, Chetal K, Bhattacharjee A, Moretto J, Leong SP, Singer MI, Parrett BM, Minor DR, McAllister S, Miller JR 3rd, Salomonis N, Kashani-Sabet M. Kim KB, et al. J Invest Dermatol. 2021 Aug;141(8):2028-2036.e2. doi: 10.1016/j.jid.2021.01.024. Epub 2021 Feb 19. J Invest Dermatol. 2021. PMID: 33610559 Free article.
Homologous recombination DNA damage repair (HR-DDR) deficient patients with various solid tumors have been treated with PARP inhibitors. ...HR-DDR gene mutation was associated with high tumor mutational burden and clinical response to checkpoint blockade. ...
Homologous recombination DNA damage repair (HR-DDR) deficient patients with various solid tumors have been treated with PARP inhibito …
Outcomes and Risk Factors in Patients with Multiple Primary Melanomas.
Nosrati A, Yu WY, McGuire J, Griffin A, de Souza JR, Singh R, Linos E, Chren MM, Grimes B, Jewell NP, Wei ML. Nosrati A, et al. J Invest Dermatol. 2019 Jan;139(1):195-201. doi: 10.1016/j.jid.2018.07.009. Epub 2018 Jul 19. J Invest Dermatol. 2019. PMID: 30031745 Free PMC article.

Risk of developing multiple melanomas increased with age at diagnosis of first melanoma (hazard ratio [HR] = 1.20 for a 10-year increase in age, 95% confidence interval [CI] = 1.11-1.29, P < 0.001), male sex (HR = 1.44, 95% CI = 1.12-1.84, P = 0.005), and white r

…
Risk of developing multiple melanomas increased with age at diagnosis of first melanoma (hazard ratio [HR] = 1.20 for a 10-year incre …
Preparation of a radiolabeled GnRH-I analogue derivative with 111 In as a new anti-proliferative agent.
Zoghi M, Nosrati SA, Rogni F, Rajabifar S. Zoghi M, et al. J Labelled Comp Radiopharm. 2018 Oct;61(12):903-911. doi: 10.1002/jlcr.3677. Epub 2018 Sep 4. J Labelled Comp Radiopharm. 2018. PMID: 30109712
The serum stability of the tracer was determined up to 24 hr. Binding affinities of Triptorelin-Hydrazide analogue were determined in a binding assay for both human and rat GnRH receptors. ...The quantities of internalization efficiency and receptor affinity of the new rad …
The serum stability of the tracer was determined up to 24 hr. Binding affinities of Triptorelin-Hydrazide analogue were determined in …