Haaksma E[au] - Search Results

Year	Number of Results
1987	1
1989	1
1990	1
1991	1
1992	1
2000	4
2003	1
2005	1
2008	4
2009	3
2010	1
2012	3
2013	3
2015	2
2021	0

1

Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker.

Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, Kraemer O, Himmelsbach F, Haaksma E, Adolf GR. Solca F, et al. Among authors: haaksma e. J Pharmacol Exp Ther. 2012 Nov;343(2):342-50. doi: 10.1124/jpet.112.197756. Epub 2012 Aug 10. J Pharmacol Exp Ther. 2012. PMID: 22888144

2

Histamine receptors: subclasses and specific ligands.

Haaksma EE, Leurs R, Timmerman H. Haaksma EE, et al. Pharmacol Ther. 1990;47(1):73-104. doi: 10.1016/0163-7258(90)90046-5. Pharmacol Ther. 1990. PMID: 2195558 Review.

3

Predicting ligand interactions with ABC transporters in ADME.

Demel MA, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. Demel MA, et al. Among authors: haaksma ee. Chem Biodivers. 2009 Nov;6(11):1960-9. doi: 10.1002/cbdv.200900138. Chem Biodivers. 2009. PMID: 19937827 Review.

4

In silico prediction of substrate properties for ABC-multidrug transporters.

Demel MA, Schwaha R, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. Demel MA, et al. Among authors: haaksma ee. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1167-80. doi: 10.1517/17425255.4.9.1167. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721111 Review.

5

A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic.

Engelhardt H, Smits RA, Leurs R, Haaksma E, de Esch IJ. Engelhardt H, et al. Among authors: haaksma e. Curr Opin Drug Discov Devel. 2009 Sep;12(5):628-43. Curr Opin Drug Discov Devel. 2009. PMID: 19736622 Review.

6

Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.

Engelhardt H, de Esch IJ, Kuhn D, Smits RA, Zuiderveld OP, Dobler J, Mayer M, Lips S, Arnhof H, Scharn D, Haaksma EE, Leurs R. Engelhardt H, et al. Among authors: haaksma ee. Eur J Med Chem. 2012 Aug;54:660-8. doi: 10.1016/j.ejmech.2012.06.016. Epub 2012 Jun 18. Eur J Med Chem. 2012. PMID: 22749391

7

Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.

Engelhardt H, Schultes S, de Graaf C, Nijmeijer S, Vischer HF, Zuiderveld OP, Dobler J, Stachurski K, Mayer M, Arnhof H, Scharn D, Haaksma EE, de Esch IJ, Leurs R. Engelhardt H, et al. Among authors: haaksma ee. J Med Chem. 2013 Jun 13;56(11):4264-76. doi: 10.1021/jm301886t. Epub 2013 May 28. J Med Chem. 2013. PMID: 23668417

8

Linking agonist binding to histamine H1 receptor activation.

Jongejan A, Bruysters M, Ballesteros JA, Haaksma E, Bakker RA, Pardo L, Leurs R. Jongejan A, et al. Among authors: haaksma e. Nat Chem Biol. 2005 Jul;1(2):98-103. doi: 10.1038/nchembio714. Epub 2005 Jun 19. Nat Chem Biol. 2005. PMID: 16408006

9

BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis.

Sanderson MP, Apgar J, Garin-Chesa P, Hofmann MH, Kessler D, Quant J, Savchenko A, Schaaf O, Treu M, Tye H, Zahn SK, Zoephel A, Haaksma E, Adolf GR, Kraut N. Sanderson MP, et al. Among authors: haaksma e. Mol Cancer Ther. 2015 Dec;14(12):2762-72. doi: 10.1158/1535-7163.MCT-15-0539. Epub 2015 Oct 5. Mol Cancer Ther. 2015. PMID: 26438154 Free article.

10

Combinatorial Consensus Scoring for Ligand-Based Virtual Fragment Screening: A Comparative Case Study for Serotonin 5-HT(3)A, Histamine H(1), and Histamine H(4) Receptors.

Schultes S, Kooistra AJ, Vischer HF, Nijmeijer S, Haaksma EE, Leurs R, de Esch IJ, de Graaf C. Schultes S, et al. Among authors: haaksma ee. J Chem Inf Model. 2015 May 26;55(5):1030-44. doi: 10.1021/ci500694c. Epub 2015 Apr 23. J Chem Inf Model. 2015. PMID: 25815783

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