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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1928 1
1946 1
1973 2
1974 1
1976 3
1977 1
1978 2
1979 1
1980 5
1981 4
1982 6
1983 7
1984 3
1985 8
1986 14
1987 2
1988 8
1989 10
1990 8
1991 8
1992 7
1993 5
1994 8
1995 10
1996 9
1997 12
1998 7
1999 12
2000 8
2001 4
2002 16
2003 13
2004 22
2005 25
2006 16
2007 21
2008 16
2009 19
2010 20
2011 23
2012 10
2013 23
2014 16
2015 14
2016 14
2017 22
2018 12
2019 12
2020 15
2021 15
2022 0
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489 results
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Page 1
The mechanisms of action of metformin.
Rena G, Hardie DG, Pearson ER. Rena G, et al. Among authors: hardie dg. Diabetologia. 2017 Sep;60(9):1577-1585. doi: 10.1007/s00125-017-4342-z. Epub 2017 Aug 3. Diabetologia. 2017. PMID: 28776086 Free PMC article. Review.
AMPK: Sensing Glucose as well as Cellular Energy Status.
Lin SC, Hardie DG. Lin SC, et al. Among authors: hardie dg. Cell Metab. 2018 Feb 6;27(2):299-313. doi: 10.1016/j.cmet.2017.10.009. Epub 2017 Nov 16. Cell Metab. 2018. PMID: 29153408 Free article. Review.
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC. Zhang CS, et al. Among authors: hardie dg. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19. Nature. 2017. PMID: 28723898 Free PMC article.
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC. Li M, et al. Among authors: hardie dg. Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13. Cell Metab. 2019. PMID: 31204282 Free PMC article.
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1.
Li M, Zhang CS, Feng JW, Wei X, Zhang C, Xie C, Wu Y, Hawley SA, Atrih A, Lamont DJ, Wang Z, Piao HL, Hardie DG, Lin SC. Li M, et al. Among authors: hardie dg. Cell Res. 2021 Apr;31(4):478-481. doi: 10.1038/s41422-020-00456-8. Epub 2020 Dec 21. Cell Res. 2021. PMID: 33349646 Free PMC article. No abstract available.
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.
Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: hardie dg. Nat Med. 2013 Dec;19(12):1649-54. doi: 10.1038/nm.3372. Epub 2013 Nov 3. Nat Med. 2013. PMID: 24185692 Free PMC article.
489 results