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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1973 1
1974 1
1981 1
1998 1
2000 2
2002 3
2003 1
2004 1
2005 3
2007 1
2008 2
2009 1
2010 1
2011 3
2013 2
2015 2
2019 2
2020 3
2021 6
2022 3
2023 1
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40 results
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Page 1
Targeting IRAK4 for Degradation with PROTACs.
Nunes J, McGonagle GA, Eden J, Kiritharan G, Touzet M, Lewell X, Emery J, Eidam H, Harling JD, Anderson NA. Nunes J, et al. Among authors: harling jd. ACS Med Chem Lett. 2019 Jun 14;10(7):1081-1085. doi: 10.1021/acsmedchemlett.9b00219. eCollection 2019 Jul 11. ACS Med Chem Lett. 2019. PMID: 31312412 Free PMC article.
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Bondeson DP, et al. Among authors: harling jd. Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10. Nat Chem Biol. 2015. PMID: 26075522 Free PMC article.
The therapeutic potential of PROTACs.
Benowitz AB, Jones KL, Harling JD. Benowitz AB, et al. Among authors: harling jd. Expert Opin Ther Pat. 2021 Jan;31(1):1-24. doi: 10.1080/13543776.2021.1840553. Epub 2021 Jan 11. Expert Opin Ther Pat. 2021. PMID: 33081540 Review.
Challenges and opportunities for in vivo PROTAC delivery.
Benowitz AB, Scott-Stevens PT, Harling JD. Benowitz AB, et al. Among authors: harling jd. Future Med Chem. 2022 Jan;14(3):119-121. doi: 10.4155/fmc-2021-0223. Epub 2021 Sep 16. Future Med Chem. 2022. PMID: 34528453 No abstract available.
Optimization of a Series of RIPK2 PROTACs.
Miah AH, Smith IED, Rackham M, Mares A, Thawani AR, Nagilla R, Haile PA, Votta BJ, Gordon LJ, Watt G, Denyer J, Fisher DT, Dace P, Giffen P, Goncalves A, Churcher I, Scott-Stevens P, Harling JD. Miah AH, et al. Among authors: harling jd. J Med Chem. 2021 Sep 9;64(17):12978-13003. doi: 10.1021/acs.jmedchem.1c01118. Epub 2021 Aug 25. J Med Chem. 2021. PMID: 34432979
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Zhang Q, Kounde CS, Mondal M, Greenfield JL, Baker JR, Kotelnikov S, Ignatov M, Tinworth CP, Zhang L, Conole D, De Vita E, Kozakov D, McCluskey A, Harling JD, Fuchter MJ, Tate EW. Zhang Q, et al. Among authors: harling jd. Chem Commun (Camb). 2022 Sep 29;58(78):10933-10936. doi: 10.1039/d2cc03092f. Chem Commun (Camb). 2022. PMID: 36065962 Free PMC article.
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs.
Law RP, Nunes J, Chung CW, Bantscheff M, Buda K, Dai H, Evans JP, Flinders A, Klimaszewska D, Lewis AJ, Muelbaier M, Scott-Stevens P, Stacey P, Tame CJ, Watt GF, Zinn N, Queisser MA, Harling JD, Benowitz AB. Law RP, et al. Among authors: harling jd. Angew Chem Int Ed Engl. 2021 Oct 18;60(43):23327-23334. doi: 10.1002/anie.202109237. Epub 2021 Sep 17. Angew Chem Int Ed Engl. 2021. PMID: 34416073
40 results