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Novel DNM1L variants impair mitochondrial dynamics through divergent mechanisms.
Nolden KA, Egner JM, Collier JJ, Russell OM, Alston CL, Harwig MC, Widlansky ME, Sasorith S, Barbosa IA, Douglas AG, Baptista J, Walker M, Donnelly DE, Morris AA, Tan HJ, Kurian MA, Gorman K, Mordekar S, Deshpande C, Samanta R, McFarland R, Hill RB, Taylor RW, Oláhová M. Nolden KA, et al. Among authors: harwig mc. Life Sci Alliance. 2022 Aug 1;5(12):e202101284. doi: 10.26508/lsa.202101284. Life Sci Alliance. 2022. PMID: 35914810 Free PMC article.
The variable domain from the mitochondrial fission mechanoenzyme Drp1 promotes liquid-liquid phase separation.
Posey AE, Bagheri M, Ross KA, Lanum EN, Khan MA, Jennings CM, Harwig MC, Kennedy NW, Hilser VJ, Harden JL, Hill RB. Posey AE, et al. Among authors: harwig mc. bioRxiv [Preprint]. 2023 May 29:2023.05.29.542732. doi: 10.1101/2023.05.29.542732. bioRxiv. 2023. Update in: Protein Sci. 2023 Nov;32(11):e4787. doi: 10.1002/pro.4787. PMID: 37398258 Free PMC article. Updated. Preprint.
Structural studies of human fission protein FIS1 reveal a dynamic region important for GTPase DRP1 recruitment and mitochondrial fission.
Egner JM, Nolden KA, Harwig MC, Bonate RP, De Anda J, Tessmer MH, Noey EL, Ihenacho UK, Liu Z, Peterson FC, Wong GCL, Widlansky ME, Hill RB. Egner JM, et al. Among authors: harwig mc. J Biol Chem. 2022 Dec;298(12):102620. doi: 10.1016/j.jbc.2022.102620. Epub 2022 Oct 20. J Biol Chem. 2022. PMID: 36272645 Free PMC article.
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression.
AbuEid M, McAllister DM, McOlash L, Harwig MC, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB. AbuEid M, et al. Among authors: harwig mc. iScience. 2021 May 25;24(6):102653. doi: 10.1016/j.isci.2021.102653. eCollection 2021 Jun 25. iScience. 2021. PMID: 34189432 Free PMC article.
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