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Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.
Hautakangas H, Winsvold BS, Ruotsalainen SE, Bjornsdottir G, Harder AVE, Kogelman LJA, Thomas LF, Noordam R, Benner C, Gormley P, Artto V, Banasik K, Bjornsdottir A, Boomsma DI, Brumpton BM, Burgdorf KS, Buring JE, Chalmer MA, de Boer I, Dichgans M, Erikstrup C, Färkkilä M, Garbrielsen ME, Ghanbari M, Hagen K, Häppölä P, Hottenga JJ, Hrafnsdottir MG, Hveem K, Johnsen MB, Kähönen M, Kristoffersen ES, Kurth T, Lehtimäki T, Lighart L, Magnusson SH, Malik R, Pedersen OB, Pelzer N, Penninx BWJH, Ran C, Ridker PM, Rosendaal FR, Sigurdardottir GR, Skogholt AH, Sveinsson OA, Thorgeirsson TE, Ullum H, Vijfhuizen LS, Widén E, van Dijk KW; International Headache Genetics Consortium; HUNT All-in Headache; Danish Blood Donor Study Genomic Cohort; Aromaa A, Belin AC, Freilinger T, Ikram MA, Järvelin MR, Raitakari OT, Terwindt GM, Kallela M, Wessman M, Olesen J, Chasman DI, Nyholt DR, Stefánsson H, Stefansson K, van den Maagdenberg AMJM, Hansen TF, Ripatti S, Zwart JA, Palotie A, Pirinen M. Hautakangas H, et al. Nat Genet. 2022 Feb;54(2):152-160. doi: 10.1038/s41588-021-00990-0. Epub 2022 Feb 3. Nat Genet. 2022. PMID: 35115687 Free PMC article.
Cluster Headache Genomewide Association Study and Meta-Analysis Identifies Eight Loci and Implicates Smoking as Causal Risk Factor.
Winsvold BS, Harder AVE, Ran C, Chalmer MA, Dalmasso MC, Ferkingstad E, Tripathi KP, Bacchelli E, Børte S, Fourier C, Petersen AS, Vijfhuizen LS, Magnusson SH, O'Connor E, Bjornsdottir G, Häppölä P, Wang YF, Callesen I, Kelderman T, Gallardo VJ, de Boer I, Olofsgård FJ, Heinze K, Lund N, Thomas LF, Hsu CL, Pirinen M, Hautakangas H, Ribasés M, Guerzoni S, Sivakumar P, Yip J, Heinze A, Küçükali F, Ostrowski SR, Pedersen OB, Kristoffersen ES, Martinsen AE, Artigas MS, Lagrata S, Cainazzo MM, Adebimpe J, Quinn O, Göbel C, Cirkel A, Volk AE, Heilmann-Heimbach S, Skogholt AH, Gabrielsen ME, Wilbrink LA, Danno D, Mehta D, Guðbjartsson DF; HUNT All-In Headache, The International Headache Genetics Consortium, DBDS Genomic Consortium; Rosendaal FR, Willems van Dijk K, Fronczek R, Wagner M, Scherer M, Göbel H, Sleegers K, Sveinsson OA, Pani L, Zoli M, Ramos-Quiroga JA, Dardiotis E, Steinberg A, Riedel-Heller S, Sjöstrand C, Thorgeirsson TE, Stefansson H, Southgate L, Trembath RC, Vandrovcova J, Noordam R, Paemeleire K, Stefansson K, Fann CS, Waldenlind E, Tronvik E, Jensen RH, Chen SP, Houlden H, Terwindt GM, Kubisch C, Maestrini E, Vikelis M, Pozo-Rosich P, Belin AC, Matharu M, van d… See abstract for full author list ➔ Winsvold BS, et al. Among authors: hautakangas h. Ann Neurol. 2023 Oct;94(4):713-726. doi: 10.1002/ana.26743. Epub 2023 Aug 7. Ann Neurol. 2023. PMID: 37486023 Free PMC article.
NCOR2 is a novel candidate gene for migraine-epilepsy phenotype.
Nuottamo ME, Häppölä P, Artto V, Hautakangas H, Pirinen M, Hiekkalinna T, Ellonen P, Lepistö M, Hämäläinen E; International Headache Genetics Consortium (IHGC), FinnGenConsortium; Siren A, Lehesjoki AE, Kallela M, Palotie A, Kaunisto MA, Wessman M. Nuottamo ME, et al. Among authors: hautakangas h. Cephalalgia. 2022 Jun;42(7):631-644. doi: 10.1177/03331024211068065. Epub 2022 Feb 15. Cephalalgia. 2022. PMID: 35166138
Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.
Saarentaus EC, Karjalainen J, Rämö JT, Kiiskinen T, Havulinna AS, Mehtonen J, Hautakangas H, Ruotsalainen S, Tamlander M, Mars N; FINNGEN; Toppila-Salmi S, Pirinen M, Kurki M, Ripatti S, Daly M, Palotie T, Mäkitie A, Palotie A. Saarentaus EC, et al. Among authors: hautakangas h. Nat Commun. 2023 Jan 18;14(1):83. doi: 10.1038/s41467-022-33626-w. Nat Commun. 2023. PMID: 36653354 Free PMC article.
Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure.
Rämö JT, Kiiskinen T, Seist R, Krebs K, Kanai M, Karjalainen J, Kurki M, Hämäläinen E, Häppölä P, Havulinna AS, Hautakangas H; FinnGen; Mägi R, Palta P, Esko T, Metspalu A, Pirinen M, Karczewski KJ, Ripatti S, Milani L, Stankovic KM, Mäkitie A, Daly MJ, Palotie A. Rämö JT, et al. Among authors: hautakangas h. Nat Commun. 2023 Jan 18;14(1):157. doi: 10.1038/s41467-022-32936-3. Nat Commun. 2023. PMID: 36653343 Free PMC article.
Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools.
Bahrami S, Hindley G, Winsvold BS, O'Connell KS, Frei O, Shadrin A, Cheng W, Bettella F, Rødevand L, Odegaard KJ, Fan CC, Pirinen MJ, Hautakangas HM; HUNT All-In Headache; Dale AM, Djurovic S, Smeland OB, Andreassen OA. Bahrami S, et al. Among authors: hautakangas hm. Brain. 2022 Mar 29;145(1):142-153. doi: 10.1093/brain/awab267. Brain. 2022. PMID: 34273149 Free PMC article.