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HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Lv K, Gong C, Antony C, Han X, Ren JG, Donaghy R, Cheng Y, Pellegrino S, Warren AJ, Paralkar VR, Tong W. Lv K, et al. Cell Stem Cell. 2021 Jul 1;28(7):1275-1290.e9. doi: 10.1016/j.stem.2021.02.008. Epub 2021 Mar 11. Cell Stem Cell. 2021. PMID: 33711283 Free PMC article.
Mechanistically, HectD1 ubiquitinates and degrades ZNF622, an assembly factor for the ribosomal 60S subunit. Hectd1 loss leads to accumulation of ZNF622 and the anti-association factor eIF6 on 60S, resulting in 60S/40S joining defects. ...
Mechanistically, HectD1 ubiquitinates and degrades ZNF622, an assembly factor for the ribosomal 60S subunit. Hectd1 loss leads …
Sequence variants in HECTD1 result in a variable neurodevelopmental disorder.
Zerafati-Jahromi G, Oxman E, Hoang HD, Charng WL, Kotla T, Yuan W, Ishibashi K, Sebaoui S, Luedtke K, Winrow B, Ganetzky RD, Ruiz A, Manso-Basúz C, Spataro N, Kannu P, Athey T, Peroutka C, Barnes C, Sidlow R, Anadiotis G, Magnussen K, Valenzuela I, Moles-Fernandez A, Berger S, Grant CL, Vilain E, Arnadottir GA, Sulem P, Sulem TS, Stefansson K, Massey S, Ginn N, Poduri A, D'Gama AM, Valentine R, Trowbridge SK, Murali CN, Franciskovich R, Tran Y, Webb BD, Keppler-Noreuil KM, Hall AL, McGivern B, Monaghan KG, Guillen Sacoto MJ, Baldridge D, Silverman GA, Dahiya S, Turner TN, Schedl T, Corbin JG, Pak SC, Zohn IE, Gurnett CA. Zerafati-Jahromi G, et al. Am J Hum Genet. 2025 Mar 6;112(3):537-553. doi: 10.1016/j.ajhg.2025.01.001. Epub 2025 Jan 28. Am J Hum Genet. 2025. PMID: 39879987 Free PMC article.
Of these 15 HECTD1 variants, 10 occurred de novo, 3 had unknown inheritance, and 2 were compound heterozygous. ...Thus, our clinical and functional data support a critical requirement of HECTD1 for human brain development....
Of these 15 HECTD1 variants, 10 occurred de novo, 3 had unknown inheritance, and 2 were compound heterozygous. ...Thus, our clinical …
HECTD1-Mediated Ubiquitination and Degradation of Rubicon Regulates Autophagy and Osteoarthritis Pathogenesis.
Liao S, Zheng Q, Shen H, Yang G, Xu Y, Zhang X, Ouyang H, Pan Z. Liao S, et al. Arthritis Rheumatol. 2023 Mar;75(3):387-400. doi: 10.1002/art.42369. Epub 2023 Jan 25. Arthritis Rheumatol. 2023. PMID: 36121967
Overexpression of HECTD1 in mouse joints alleviated OA pathogenesis, whereas conditional depletion of Hectd1 in cartilage samples aggravated surgery- and aging-induced OA pathogenesis. ...CONCLUSION: HECTD1 plays a crucial role in the pathogenesis of OA, in t …
Overexpression of HECTD1 in mouse joints alleviated OA pathogenesis, whereas conditional depletion of Hectd1 in cartilage samp …
Hectd1 is essential for embryogenesis in mice.
D'Alonzo D, Emch FH, Shen X, Bruder E, De Geyter C, Zhang H. D'Alonzo D, et al. Gene Expr Patterns. 2019 Dec;34:119064. doi: 10.1016/j.gep.2019.119064. Epub 2019 Jul 10. Gene Expr Patterns. 2019. PMID: 31301385
Furthermore, the expression of Hectd1 was regulated by insulin and by both heat and hypoxia. Thus, our studies reveal that Hectd1 is indispensable for normal embryogenesis and fetal survival. The generation of this new Hectd1 mutant mouse model provides ample …
Furthermore, the expression of Hectd1 was regulated by insulin and by both heat and hypoxia. Thus, our studies reveal that Hectd1 …
HECTD1 regulates the expression of SNAIL: Implications for epithelial-mesenchymal transition.
Wang X, De Geyter C, Jia Z, Peng Y, Zhang H. Wang X, et al. Int J Oncol. 2020 May;56(5):1186-1198. doi: 10.3892/ijo.2020.5002. Epub 2020 Feb 27. Int J Oncol. 2020. PMID: 32319576 Free PMC article.
Under hypoxic conditions, HECTD1 expression levels were decreased by microRNA (miRNA or miR)-210. Upon the observation of genetic abnormalities in the HECTD1 gene in cervical cancer specimens, it was observed that the decreased expression levels of HECTD1 wer …
Under hypoxic conditions, HECTD1 expression levels were decreased by microRNA (miRNA or miR)-210. Upon the observation of genetic abn …
Centriolin interacts with HectD1 in a cell cycle dependent manner.
Salas J, Garcia A, Zora V, Dornbush S, Mousa-Ibrahim F, Fogg H, Gromley Z, Gromley A. Salas J, et al. BMC Res Notes. 2023 Dec 19;16(1):375. doi: 10.1186/s13104-023-06670-y. BMC Res Notes. 2023. PMID: 38115153 Free PMC article.
RESULTS: This study provides evidence that the ubiquitin E3 ligase HectD1 binds to centriolin and that this association likely accounts for our observation that HectD1 co-localizes with centriolin at the centrosome during mitosis. ...We propose that the interaction …
RESULTS: This study provides evidence that the ubiquitin E3 ligase HectD1 binds to centriolin and that this association likely accoun …
Low HECTD1 mRNA expression is associated with poor prognosis and may be correlated with increased mitochondrial respiratory function in breast cancer.
Uemoto Y, Katsuta E, Kondo N, Wanifuchi-Endo Y, Fujita T, Asano T, Hisada T, Terada M, Kato A, Okuda K, Sugiura H, Komura M, Kato H, Osaga S, Takahashi S, Toyama T. Uemoto Y, et al. Am J Cancer Res. 2022 Apr 15;12(4):1593-1605. eCollection 2022. Am J Cancer Res. 2022. PMID: 35530276 Free PMC article.
We also examined the prognostic significance of HECTD1 mRNA expression by multivariate analysis and HECTD1 protein expression by immunohistochemistry using our cohort. ...There was no association of HECTD1 protein expression with HECTD1 mRNA expression …
We also examined the prognostic significance of HECTD1 mRNA expression by multivariate analysis and HECTD1 protein expression …
circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress.
Chen L, Luo W, Zhang W, Chu H, Wang J, Dai X, Cheng Y, Zhu T, Chao J. Chen L, et al. RNA Biol. 2020 Feb;17(2):240-253. doi: 10.1080/15476286.2019.1676114. Epub 2019 Oct 13. RNA Biol. 2020. PMID: 31607223 Free PMC article.
A mouse myocardial I/R model using C57 mice was established to confirm the in vitro findings.Results: In HUVECs, I/R induced a significant time-dependent decrease in HECTD1 associated with an approximately 45% decrease in cell viability and increases in cell apoptosis and …
A mouse myocardial I/R model using C57 mice was established to confirm the in vitro findings.Results: In HUVECs, I/R induced a significant t …
Hectd1 is required for development of the junctional zone of the placenta.
Sarkar AA, Nuwayhid SJ, Maynard T, Ghandchi F, Hill JT, Lamantia AS, Zohn IE. Sarkar AA, et al. Dev Biol. 2014 Aug 15;392(2):368-80. doi: 10.1016/j.ydbio.2014.05.007. Epub 2014 May 20. Dev Biol. 2014. PMID: 24855001 Free PMC article.
Here we demonstrate that the Homologous to the E6-AP Carboxyl Terminus (HECT) domain E3 ubiquitin ligase, Hectd1, is essential for development of the mouse placenta. Hectd1 is widely expressed during placentation with enrichment in trophoblast giant cells (TGCs) and …
Here we demonstrate that the Homologous to the E6-AP Carboxyl Terminus (HECT) domain E3 ubiquitin ligase, Hectd1, is essential for de …
HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.
Bennett L, Madders ECET, Parsons JL. Bennett L, et al. Nucleic Acids Res. 2020 Feb 20;48(3):1301-1313. doi: 10.1093/nar/gkz1129. Nucleic Acids Res. 2020. PMID: 31799632 Free PMC article.
We subsequently purified an activity from HeLa cell extracts and identify this as the E3 ubiquitin ligase, HECTD1. We demonstrate that a recombinant truncated form of HECTD1 can stimulate incision of THF-in by APE1 in vitro by histone ubiquitylation, and that siRNA- …
We subsequently purified an activity from HeLa cell extracts and identify this as the E3 ubiquitin ligase, HECTD1. We demonstrate tha …
89 results