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Vehicle Systems and Excipients Used in Minipig Drug Development Studies.

Weaver ML, Grossi AB, Schützsack J, Parish J, Løgsted J, Bøgh IB, Cameron D, Harvey W, Festag M, Downes N, Venturella S, Schlichtiger J, Mhedhbi S, Ross V, Kissner T, Stark C, Milano S, Heining P, Sanchez-Felix M. Weaver ML, et al. Among authors: heining p. Toxicol Pathol. 2016 Apr;44(3):367-72. doi: 10.1177/0192623315613088. Epub 2015 Dec 16. Toxicol Pathol. 2016. PMID: 26674803 Review.

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Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis.

Brinkmann V, Billich A, Baumruker T, Heining P, Schmouder R, Francis G, Aradhye S, Burtin P. Brinkmann V, et al. Among authors: heining p. Nat Rev Drug Discov. 2010 Nov;9(11):883-97. doi: 10.1038/nrd3248. Epub 2010 Oct 29. Nat Rev Drug Discov. 2010. PMID: 21031003 Review.

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The industry view on long-term toxicology testing in drug development of human pharmaceuticals.

Van Cauteren H, Bentley P, Bode G, Cordier A, Coussement W, Heining P, Sims J. Van Cauteren H, et al. Among authors: heining p. Pharmacol Toxicol. 2000;86 Suppl 1:1-5. doi: 10.1034/j.1600-0773.2000.d01-1.x. Pharmacol Toxicol. 2000. PMID: 10905744 Review.

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Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.

Pan S, Gray NS, Gao W, Mi Y, Fan Y, Wang X, Tuntland T, Che J, Lefebvre S, Chen Y, Chu A, Hinterding K, Gardin A, End P, Heining P, Bruns C, Cooke NG, Nuesslein-Hildesheim B. Pan S, et al. Among authors: heining p. ACS Med Chem Lett. 2013 Jan 4;4(3):333-7. doi: 10.1021/ml300396r. eCollection 2013 Mar 14. ACS Med Chem Lett. 2013. PMID: 24900670 Free PMC article.

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Pregnancy outcomes in the clinical development program of fingolimod in multiple sclerosis.

Karlsson G, Francis G, Koren G, Heining P, Zhang X, Cohen JA, Kappos L, Collins W. Karlsson G, et al. Among authors: heining p. Neurology. 2014 Feb 25;82(8):674-80. doi: 10.1212/WNL.0000000000000137. Epub 2014 Jan 24. Neurology. 2014. PMID: 24463630 Free PMC article.

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The Potential of Minipigs in the Development of Anticancer Therapeutics: Species Comparison and Examples of Special Applications.

Mahl A, Dincer Z, Heining P. Mahl A, et al. Among authors: heining p. Toxicol Pathol. 2016 Apr;44(3):391-7. doi: 10.1177/0192623315619040. Epub 2015 Dec 23. Toxicol Pathol. 2016. PMID: 26698323

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The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry: Results of an IQ DruSafe Minipig Survey.

Colleton C, Brewster D, Chester A, Clarke DO, Heining P, Olaharski A, Graziano M. Colleton C, et al. Among authors: heining p. Toxicol Pathol. 2016 Apr;44(3):458-66. doi: 10.1177/0192623315617562. Toxicol Pathol. 2016. PMID: 27006130

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The Use of Minipig in Drug Discovery and Development: Pros and Cons of Minipig Selection and Strategies to Use as a Preferred Nonrodent Species.

Heining P, Ruysschaert T. Heining P, et al. Toxicol Pathol. 2016 Apr;44(3):467-73. doi: 10.1177/0192623315610823. Epub 2015 Dec 16. Toxicol Pathol. 2016. PMID: 26674804

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Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

Meno-Tetang GM, Li H, Mis S, Pyszczynski N, Heining P, Lowe P, Jusko WJ. Meno-Tetang GM, et al. Among authors: heining p. Drug Metab Dispos. 2006 Sep;34(9):1480-7. doi: 10.1124/dmd.105.009001. Epub 2006 Jun 2. Drug Metab Dispos. 2006. PMID: 16751263

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Cardiac troponins and creatine kinase content of striated muscle in common laboratory animals.

Fredericks S, Merton GK, Lerena MJ, Heining P, Carter ND, Holt DW. Fredericks S, et al. Among authors: heining p. Clin Chim Acta. 2001 Feb;304(1-2):65-74. doi: 10.1016/s0009-8981(00)00409-5. Clin Chim Acta. 2001. PMID: 11165200

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