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Page 1
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
Johannes JW, Balazs A, Barratt D, Bista M, Chuba MD, Cosulich S, Critchlow SE, Degorce SL, Di Fruscia P, Edmondson SD, Embrey K, Fawell S, Ghosh A, Gill SJ, Gunnarsson A, Hande SM, Heightman TD, Hemsley P, Illuzzi G, Lane J, Larner C, Leo E, Liu L, Madin A, Martin S, McWilliams L, O'Connor MJ, Orme JP, Pachl F, Packer MJ, Pei X, Pike A, Schimpl M, She H, Staniszewska AD, Talbot V, Underwood E, Varnes JG, Xue L, Yao T, Zhang K, Zhang AX, Zheng X. Johannes JW, et al. Among authors: hemsley p. J Med Chem. 2021 Oct 14;64(19):14498-14512. doi: 10.1021/acs.jmedchem.1c01012. Epub 2021 Sep 27. J Med Chem. 2021. PMID: 34570508
S-acylation in plants: an expanding field.
Hemsley PA. Hemsley PA. Biochem Soc Trans. 2020 Apr 29;48(2):529-536. doi: 10.1042/BST20190703. Biochem Soc Trans. 2020. PMID: 32239188 Review.
Multiple roles for protein palmitoylation in plants.
Hemsley PA, Grierson CS. Hemsley PA, et al. Trends Plant Sci. 2008 Jun;13(6):295-302. doi: 10.1016/j.tplants.2008.04.006. Epub 2008 May 22. Trends Plant Sci. 2008. PMID: 18501662 Review.
38 results