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SNM1A is crucial for efficient repair of complex DNA breaks in human cells.
Swift LP, Lagerholm BC, Henderson LR, Ratnaweera M, Baddock HT, Sengerova B, Lee S, Cruz-Migoni A, Waithe D, Renz C, Ulrich HD, Newman JA, Schofield CJ, McHugh PJ. Swift LP, et al. Among authors: henderson lr. Nat Commun. 2024 Jun 25;15(1):5392. doi: 10.1038/s41467-024-49583-5. Nat Commun. 2024. PMID: 38918391 Free PMC article.
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target.
Bielinski M, Henderson LR, Yosaatmadja Y, Swift LP, Baddock HT, Bowen MJ, Brem J, Jones PS, McElroy SP, Morrison A, Speake M, van Boeckel S, van Doornmalen E, van Groningen J, van den Hurk H, Gileadi O, Newman JA, McHugh PJ, Schofield CJ. Bielinski M, et al. Among authors: henderson lr. Chem Sci. 2024 Apr 30;15(21):8227-8241. doi: 10.1039/d4sc00367e. eCollection 2024 May 29. Chem Sci. 2024. PMID: 38817593 Free PMC article.
16 results