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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 2
1989 2
1990 1
1991 2
1992 3
1993 2
1994 4
1995 4
1996 7
1997 3
1998 3
1999 4
2000 3
2001 9
2002 9
2003 8
2004 4
2005 3
2006 10
2007 3
2008 6
2009 8
2010 9
2011 13
2012 7
2013 7
2014 10
2015 9
2016 8
2017 9
2018 4
2019 1
2020 5
2021 7
2022 8
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183 results
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Page 1
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schlünzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A. Günther S, et al. Among authors: hilgenfeld r. Science. 2021 May 7;372(6542):642-646. doi: 10.1126/science.abf7945. Epub 2021 Apr 2. Science. 2021. PMID: 33811162 Free PMC article.
The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells.
Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M. Wenzel J, et al. Among authors: hilgenfeld r. Nat Neurosci. 2021 Nov;24(11):1522-1533. doi: 10.1038/s41593-021-00926-1. Epub 2021 Oct 21. Nat Neurosci. 2021. PMID: 34675436 Free PMC article.
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment.
Zhang L, Lin D, Kusov Y, Nian Y, Ma Q, Wang J, von Brunn A, Leyssen P, Lanko K, Neyts J, de Wilde A, Snijder EJ, Liu H, Hilgenfeld R. Zhang L, et al. Among authors: hilgenfeld r. J Med Chem. 2020 May 14;63(9):4562-4578. doi: 10.1021/acs.jmedchem.9b01828. Epub 2020 Feb 24. J Med Chem. 2020. PMID: 32045235 Free PMC article.
Design of wide-spectrum inhibitors targeting coronavirus main proteases.
Yang H, Xie W, Xue X, Yang K, Ma J, Liang W, Zhao Q, Zhou Z, Pei D, Ziebuhr J, Hilgenfeld R, Yuen KY, Wong L, Gao G, Chen S, Chen Z, Ma D, Bartlam M, Rao Z. Yang H, et al. Among authors: hilgenfeld r. PLoS Biol. 2005 Oct;3(10):e324. doi: 10.1371/journal.pbio.0030324. Epub 2005 Sep 6. PLoS Biol. 2005. PMID: 16128623 Free PMC article.
Accessory proteins of SARS-CoV and other coronaviruses.
Liu DX, Fung TS, Chong KK, Shukla A, Hilgenfeld R. Liu DX, et al. Among authors: hilgenfeld r. Antiviral Res. 2014 Sep;109:97-109. doi: 10.1016/j.antiviral.2014.06.013. Epub 2014 Jul 1. Antiviral Res. 2014. PMID: 24995382 Free PMC article. Review.
Viral enzymes.
Mesters JR, Tan J, Hilgenfeld R. Mesters JR, et al. Among authors: hilgenfeld r. Curr Opin Struct Biol. 2006 Dec;16(6):776-86. doi: 10.1016/j.sbi.2006.10.010. Epub 2006 Nov 7. Curr Opin Struct Biol. 2006. PMID: 17085042 Free PMC article. Review.
Structural biology in the fight against COVID-19.
Bárcena M, Barnes CO, Beck M, Bjorkman PJ, Canard B, Gao GF, Gao Y, Hilgenfeld R, Hummer G, Patwardhan A, Santoni G, Saphire EO, Schaffitzel C, Schendel SL, Smith JL, Thorn A, Veesler D, Zhang P, Zhou Q. Bárcena M, et al. Among authors: hilgenfeld r. Nat Struct Mol Biol. 2021 Jan;28(1):2-7. doi: 10.1038/s41594-020-00544-8. Nat Struct Mol Biol. 2021. PMID: 33437043 No abstract available.
183 results