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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. Francis R, et al. Among authors: himes cs. Dev Cell. 2002 Jul;3(1):85-97. doi: 10.1016/s1534-5807(02)00189-2. Dev Cell. 2002. PMID: 12110170 Free article.
The gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester reduces A beta levels in vivo in plasma and cerebrospinal fluid in young (plaque-free) and aged (plaque-bearing) Tg2576 mice.
Lanz TA, Himes CS, Pallante G, Adams L, Yamazaki S, Amore B, Merchant KM. Lanz TA, et al. Among authors: himes cs. J Pharmacol Exp Ther. 2003 Jun;305(3):864-71. doi: 10.1124/jpet.102.048280. Epub 2003 Mar 6. J Pharmacol Exp Ther. 2003. PMID: 12626636