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2019 2
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2025 2

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14 results

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Page 1
Targeted protein degradation via intramolecular bivalent glues.
Hsia O, Hinterndorfer M, Cowan AD, Iso K, Ishida T, Sundaramoorthy R, Nakasone MA, Imrichova H, Schätz C, Rukavina A, Husnjak K, Wegner M, Correa-Sáez A, Craigon C, Casement R, Maniaci C, Testa A, Kaulich M, Dikic I, Winter GE, Ciulli A. Hsia O, et al. Among authors: hinterndorfer m. Nature. 2024 Mar;627(8002):204-211. doi: 10.1038/s41586-024-07089-6. Epub 2024 Feb 21. Nature. 2024. PMID: 38383787 Free PMC article.
Targeted protein degradation for cancer therapy.
Hinterndorfer M, Spiteri VA, Ciulli A, Winter GE. Hinterndorfer M, et al. Nat Rev Cancer. 2025 Jul;25(7):493-516. doi: 10.1038/s41568-025-00817-8. Epub 2025 Apr 25. Nat Rev Cancer. 2025. PMID: 40281114 Review.
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
de Almeida M, Hinterndorfer M, Brunner H, Grishkovskaya I, Singh K, Schleiffer A, Jude J, Deswal S, Kalis R, Vunjak M, Lendl T, Imre R, Roitinger E, Neumann T, Kandolf S, Schutzbier M, Mechtler K, Versteeg GA, Haselbach D, Zuber J. de Almeida M, et al. Among authors: hinterndorfer m. Nature. 2021 Nov;599(7885):491-496. doi: 10.1038/s41586-021-04035-8. Epub 2021 Oct 28. Nature. 2021. PMID: 34711951
Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute.
Wang B, Wang M, Zhang W, Xiao T, Chen CH, Wu A, Wu F, Traugh N, Wang X, Li Z, Mei S, Cui Y, Shi S, Lipp JJ, Hinterndorfer M, Zuber J, Brown M, Li W, Liu XS. Wang B, et al. Among authors: hinterndorfer m. Nat Protoc. 2019 Mar;14(3):756-780. doi: 10.1038/s41596-018-0113-7. Epub 2019 Feb 1. Nat Protoc. 2019. PMID: 30710114 Free PMC article.
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Kagiou C, et al. Among authors: hinterndorfer m. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. Nat Commun. 2024. PMID: 38926334 Free PMC article.
High-throughput diversification of protein-ligand surfaces to discover chemical inducers of proximity.
Shaum JB, Muñoz I Ordoño M, Steen EA, Wenge DV, Cheong H, Hunkeler M, Bilotta EM, Rutter Z, Barta PA, Thornhill AM, Milosevich N, Hargis LM, Janowski J, Bishop TR, Carter TR, da Camara B, Hinterndorfer M, Dada L, He WJ, Offensperger F, Furihata H, Schweber SR, Hatton C, Wen Y, Cravatt BF, Engle KM, Donovan KA, Melillo B, Kitamura S, Ciulli A, Armstrong SA, Fischer ES, Winter GE, Erb MA. Shaum JB, et al. Among authors: hinterndorfer m. bioRxiv [Preprint]. 2025 Sep 4:2024.09.30.615685. doi: 10.1101/2024.09.30.615685. bioRxiv. 2025. PMID: 40950085 Free PMC article. Preprint.
Precision RNAi using synthetic shRNAmir target sites.
Hoffmann T, Hörmann A, Corcokovic M, Zmajkovic J, Hinterndorfer M, Salkanovic J, Spreitzer F, Köferle A, Gitschtaler K, Popa A, Oberndorfer S, Andersch F, Schaefer M, Fellner M, Budano N, Ruppert JG, Chetta P, Wurm M, Zuber J, Neumüller RA. Hoffmann T, et al. Among authors: hinterndorfer m. Elife. 2023 Aug 8;12:RP84792. doi: 10.7554/eLife.84792. Elife. 2023. PMID: 37552050 Free PMC article.
Discovery of a Drug-like, Natural Product-Inspired DCAF11 Ligand Chemotype.
Xue G, Xie J, Hinterndorfer M, Cigler M, Dötsch L, Imrichova H, Lampe P, Cheng X, Adariani SR, Winter GE, Waldmann H. Xue G, et al. Among authors: hinterndorfer m. Nat Commun. 2023 Nov 30;14(1):7908. doi: 10.1038/s41467-023-43657-6. Nat Commun. 2023. PMID: 38036533 Free PMC article.
SPOP targets the immune transcription factor IRF1 for proteasomal degradation.
Schwartz I, Vunjak M, Budroni V, Cantoran García A, Mastrovito M, Soderholm A, Hinterndorfer M, de Almeida M, Hacker K, Wang J, Froussios K, Jude J, Decker T, Zuber J, Versteeg GA. Schwartz I, et al. Among authors: hinterndorfer m. Elife. 2023 Aug 25;12:e89951. doi: 10.7554/eLife.89951. Elife. 2023. PMID: 37622993 Free PMC article.
14 results