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Page 1
Did you mean hnrnp u (268 results)?
HNRNPU-Related Neurodevelopmental Disorder.
Balasubramanian M. Balasubramanian M. 2022 Mar 10. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. 2022 Mar 10. In: Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2026. PMID: 35274911 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: HNRNPU-related neurodevelopmental disorder (HNRNPU-NDD) is characterized by developmental delay and intellectual disability - typically moderate to severe - with speech and language delay and/or absent speech. ...Agents/circumstances to avo …
CLINICAL CHARACTERISTICS: HNRNPU-related neurodevelopmental disorder (HNRNPU-NDD) is characterized by developmental delay and …
Targeting HNRNPU to overcome cisplatin resistance in bladder cancer.
Shi ZD, Hao L, Han XX, Wu ZX, Pang K, Dong Y, Qin JX, Wang GY, Zhang XM, Xia T, Liang Q, Zhao Y, Li R, Zhang SQ, Zhang JH, Chen JG, Wang GC, Chen ZS, Han CH. Shi ZD, et al. Mol Cancer. 2022 Feb 7;21(1):37. doi: 10.1186/s12943-022-01517-9. Mol Cancer. 2022. PMID: 35130920 Free PMC article.
In the high HNRNPU expressing T24 cancer cells, knockout of HNRNPU inhibited cell proliferation, invasion, and migration. ...High HNRNPU level was negatively correlated with patient survival. Transcriptomic profiling analysis showed that knockout of HNRNPU …
In the high HNRNPU expressing T24 cancer cells, knockout of HNRNPU inhibited cell proliferation, invasion, and migration. ...H …
hnRNPU is required for spermatogonial stem cell pool establishment in mice.
Wen Y, Zhou S, Gui Y, Li Z, Yin L, Xu W, Feng S, Ma X, Gan S, Xiong M, Dong J, Cheng K, Wang X, Yuan S. Wen Y, et al. Cell Rep. 2024 Apr 23;43(4):114113. doi: 10.1016/j.celrep.2024.114113. Epub 2024 Apr 15. Cell Rep. 2024. PMID: 38625792 Free article.
Moreover, hnRNPU deletion leads to the accumulation of ProSG and disrupts the process of T1-ProSG to T2-ProSG transition. Single-cell transcriptional analyses reveal that germ cells are in a mitotically quiescent state and lose their unique identity upon hnRNPU depl …
Moreover, hnRNPU deletion leads to the accumulation of ProSG and disrupts the process of T1-ProSG to T2-ProSG transition. Single-cell …
Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU.
Cai Y, Ji Y, Liu Y, Zhang D, Gong Z, Li L, Chen X, Liang C, Feng S, Lu J, Qiu Q, Lin Z, Wang Y, Cui L. Cai Y, et al. Theranostics. 2024 Jul 1;14(10):4058-4075. doi: 10.7150/thno.96890. eCollection 2024. Theranostics. 2024. PMID: 38994030 Free PMC article.
Mechanistically, we found that circ-UBE2K binds to heterogeneous nuclear ribonucleoprotein U (HNRNPU) to form a complex that upregulates the expression of the parental gene ubiquitin conjugating enzyme E2 K (UBE2K), leading to abnormal microglial activation and neuroinflam …
Mechanistically, we found that circ-UBE2K binds to heterogeneous nuclear ribonucleoprotein U (HNRNPU) to form a complex that upregula …
HNRNPU promotes the progression of triple-negative breast cancer via RNA transcription and alternative splicing mechanisms.
Han BY, Liu Z, Hu X, Ling H. Han BY, et al. Cell Death Dis. 2022 Nov 8;13(11):940. doi: 10.1038/s41419-022-05376-6. Cell Death Dis. 2022. PMID: 36347834 Free PMC article.
In this study, we employed an integrated genetic screen to identify a pivotal oncogenic factor, heterogeneous nuclear ribonucleoprotein U (HNRNPU), which is required for the progression of TNBC. We elucidated the pro-oncogenic role of HNRNPU, which can induce the pr …
In this study, we employed an integrated genetic screen to identify a pivotal oncogenic factor, heterogeneous nuclear ribonucleoprotein U ( …
hnRNPU in Sertoli cells cooperates with WT1 and is essential for testicular development by modulating transcriptional factors Sox8/9.
Wen Y, Ma X, Wang X, Wang F, Dong J, Wu Y, Lv C, Liu K, Zhang Y, Zhang Z, Yuan S. Wen Y, et al. Theranostics. 2021 Oct 25;11(20):10030-10046. doi: 10.7150/thno.66819. eCollection 2021. Theranostics. 2021. PMID: 34815802 Free PMC article.
Methods: We used the Sertoli cell-specific conditional knockout strategy (Cre/Loxp) in mice and molecular biological analyses (Luciferase assay, ChIP-qPCR, RNA-Seq, etc.) in vitro and in vivo to study the physiological roles of hnRNPU in Sertoli cells on regulating testicu …
Methods: We used the Sertoli cell-specific conditional knockout strategy (Cre/Loxp) in mice and molecular biological analyses (Luciferase as …
RNA-binding protein hnRNPU regulates multiple myeloma resistance to selinexor.
Wang X, Xu J, Li Q, Zhang Y, Lin Z, Zhai X, Wang F, Huang J, Gao Q, Wen J, Li L, Feng Y, Luo H, Li Q, Liu X, Li J, Zhao F, Zhang L, Niu T, Sun C, Zheng Y. Wang X, et al. Cancer Lett. 2024 Jan 1;580:216486. doi: 10.1016/j.canlet.2023.216486. Epub 2023 Nov 18. Cancer Lett. 2024. PMID: 37984724
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is an RNA-binding protein and a component of hnRNP complexes. Here we found that hnRNPU regulates MM sensitivity to selinexor. Cell apoptosis assays were performed to compare selinexor-induced cell death in control …
Heterogeneous nuclear ribonucleoprotein U (hnRNPU) is an RNA-binding protein and a component of hnRNP complexes. Here we found that …
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression.
Li H, Jiao W, Song J, Wang J, Chen G, Li D, Wang X, Bao B, Du X, Cheng Y, Yang C, Tong Q, Zheng L. Li H, et al. J Exp Clin Cancer Res. 2023 Nov 23;42(1):313. doi: 10.1186/s13046-023-02898-5. J Exp Clin Cancer Res. 2023. PMID: 37993881 Free PMC article.
Mechanistically, circ-hnRNPU physically interacted with non-POU domain containing octamer binding (NONO) protein to induce its cytoplasmic retention, resulting in down-regulation of glycosyltransferases (GALNT2, GALNT6, MGAT1) and parental gene hnRNPU via repression …
Mechanistically, circ-hnRNPU physically interacted with non-POU domain containing octamer binding (NONO) protein to induce its cytopl …
hnRNPU-mediated pathogenic alternative splicing drives gastric cancer progression.
Jin G, Song Y, Fang S, Yan M, Yang Z, Shao Y, Zhao K, Liu M, Wang Z, Guo Z, Dong Z. Jin G, et al. J Exp Clin Cancer Res. 2025 Jan 7;44(1):8. doi: 10.1186/s13046-024-03264-9. J Exp Clin Cancer Res. 2025. PMID: 39773744 Free PMC article.
METHODS: We analyzed AS events in various tumor samples and identified hnRNPU as a key splicing factor in GC. The effects of hnRNPU on cancer progression were assessed through in vitro and in vivo experiments. ...Genetic depletion of hnRNPU significantly redu …
METHODS: We analyzed AS events in various tumor samples and identified hnRNPU as a key splicing factor in GC. The effects of hnRNP …
Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders.
Wang T, Hoekzema K, Vecchio D, Wu H, Sulovari A, Coe BP, Gillentine MA, Wilfert AB, Perez-Jurado LA, Kvarnung M, Sleyp Y, Earl RK, Rosenfeld JA, Geisheker MR, Han L, Du B, Barnett C, Thompson E, Shaw M, Carroll R, Friend K, Catford R, Palmer EE, Zou X, Ou J, Li H, Guo H, Gerdts J, Avola E, Calabrese G, Elia M, Greco D, Lindstrand A, Nordgren A, Anderlid BM, Vandeweyer G, Van Dijck A, Van der Aa N, McKenna B, Hancarova M, Bendova S, Havlovicova M, Malerba G, Bernardina BD, Muglia P, van Haeringen A, Hoffer MJV, Franke B, Cappuccio G, Delatycki M, Lockhart PJ, Manning MA, Liu P, Scheffer IE, Brunetti-Pierri N, Rommelse N, Amaral DG, Santen GWE, Trabetti E, Sedláček Z, Michaelson JJ, Pierce K, Courchesne E, Kooy RF; SPARK Consortium; Nordenskjöld M, Romano C, Peeters H, Bernier RA, Gecz J, Xia K, Eichler EE. Wang T, et al. Nat Commun. 2020 Oct 1;11(1):4932. doi: 10.1038/s41467-020-18723-y. Nat Commun. 2020. PMID: 33004838 Free PMC article.
In addition to doubling the number of patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk genes (CTCF, HNRNPU, KCNQ3, ZBTB18, TCF12, SPEN, and LEO1) based on this large-scale targeted sequencing effort....
In addition to doubling the number of patients for many NDD risk genes, we present phenotype-genotype correlations for seven risk genes (CTC …
279 results