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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Among authors: hollingsworth lr. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation.
Hollingsworth LR, Sharif H, Griswold AR, Fontana P, Mintseris J, Dagbay KB, Paulo JA, Gygi SP, Bachovchin DA, Wu H. Hollingsworth LR, et al. Nature. 2021 Apr;592(7856):778-783. doi: 10.1038/s41586-021-03350-4. Epub 2021 Mar 17. Nature. 2021. PMID: 33731932 Free PMC article.
Mechanism and Regulation of Gasdermin-Mediated Cell Death.
Xia S, Hollingsworth LR 4th, Wu H. Xia S, et al. Among authors: hollingsworth lr 4th. Cold Spring Harb Perspect Biol. 2020 Mar 2;12(3):a036400. doi: 10.1101/cshperspect.a036400. Cold Spring Harb Perspect Biol. 2020. PMID: 31451512 Free PMC article. Review.
Speak out against tuition waiver taxes.
Hollingsworth LR 4th, Veeraraghavan P, Wu KJ, McCoy DE, Van Dervort A, Gunther KE. Hollingsworth LR 4th, et al. Science. 2017 Dec 15;358(6369):1395. doi: 10.1126/science.aar6663. Science. 2017. PMID: 29242337 No abstract available.
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.
Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Barrow JJ, et al. Among authors: hollingsworth lr 4th. Mol Cell. 2016 Oct 6;64(1):163-175. doi: 10.1016/j.molcel.2016.08.023. Epub 2016 Sep 22. Mol Cell. 2016. PMID: 27666594 Free PMC article.
11 results